Anti-atherosclerotic properties of radical-containing nanoparticle

• Project/Area Number: 26670448
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: University of Tsukuba
• Principal Investigator: SHIMANO Hitoshi 筑波大学, 医学医療系, 教授 (20251241)
• Co-Investigator(Kenkyū-buntansha): MATSUZAKA Takashi 筑波大学, 医学医療系, 准教授 (70400679)
• Project Period (FY): 2014-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: ナノメディシン / 動脈硬化 / ナノテクノロジー / 腸内細菌叢 / 腸管透過性

Outline of Final Research Achievements

pH-insensitive radical-containing nanoparticle (RNP-O) is a newly synthesized nanoparticle intended to treat oxidative stress related disease. We assessed the effects of RNP-O on atherosclerosis. RNP-O treatment significantly decreased the atherosclerotic lesion area in western diet-fed LDLRKO mice. RNP-O treatment also caused the change of microbiota. RNP-O can be a novel anti-atherogenic candidate through regulation of microbiota.

Research Products

• [Journal Article] Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver. (2014)
  • Author(s): Ehara T, Kamei Y, Yuan X, Takahashi M, Kanai S, Tamura E, Tsujimoto K, Tamiya T, Nakagawa Y, Shimano H, Takai-Igarashi T, Hatada I, Suganami T, Hashimoto K, Ogawa Y.
  • Journal Title: Diabetes. Volume: 64(3) Issue: 3 Pages: 775-84
  • DOI: 10.2337/db14-0158
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hepatic CREB3L3 Controls Whole-Body Energy Homeostasis and Improves Obesity and Diabetes (2014)
  • Author(s): Yoshimi Nakagawa,* Aoi Satoh,* Sachiko Yabe,* Mika Furusawa, Naoko Tokushige, Hitomi Tezuka, Motoki Mikami, Wakiko Iwata, Akiko Shingyouchi, Takashi Matsuzaka, Shiori Kiwata, Yuri Fujimoto, Yasushi Kawakami, Osamu Urayama, Nobuhiro Yamada, and Hitoshi Shimano et. al
  • Journal Title: Endocrinology Volume: 155(12) Issue: 12 Pages: 4706-4719
  • DOI: 10.1210/en.2014-1113
  • Peer Reviewed
• [Journal Article] Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion. (2014)
  • Author(s): Tang N, Matsuzaka T, Suzuki M, Nakano Y, Zao H, Yokoo T, Suzuki-Kemuriyama N, Kuba M, Okajima Y, Takeuchi Y, Kobayashi K, Iwasaki H, Yatoh S, Takahashi A, Suzuki H, Sone H, Shimada M, Nakagawa Y, Yahagi N, Yamada N, Shimano H.
  • Journal Title: Biochem Biophys Res Commun. Volume: 450(1) Issue: 1 Pages: 318-23
  • DOI: 10.1016/j.bbrc.2014.05.113
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. (2014)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K.
  • Journal Title: Scientific Reports Volume: 4 Issue: 1 Pages: 5312-5312
  • DOI: 10.1038/srep05312
  • Peer Reviewed / Open Access
• [Journal Article] MafB promotes atherosclerosis by inhibiting foam-cell apoptosis (2014)
  • Author(s): Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonz P, Takahashi S
  • Journal Title: Nat Commun Volume: 5 Issue: 1 Pages: 3147-3147
  • DOI: 10.1038/ncomms4147
  • Peer Reviewed / Open Access
• [Presentation] 脂質酸の量と質からみた脂肪毒性病態と糖尿病 (2015)
  • Author(s): 島野仁
  • Organizer: 第49回糖尿病学の進歩
  • Place of Presentation: ホテルグランヴィア岡山
  • Year and Date: 2015-02-20
  • Invited
• [Presentation] 脂質の質に視点をおいた生活習慣病治療戦略 (2015)
  • Author(s): 島野仁
  • Organizer: つくば医工連携フォーラム2015～食と農から医療・健康を科学する
  • Place of Presentation: 農林水産技術会議筑波事務所内 農林ホール
  • Year and Date: 2015-01-23
  • Invited
• [Presentation] 新たな脂質の質的指標：脂肪酸鎖長を介した生体制御と病態の臓器的展開、Elovl6KOマウス解析を通じて (2014)
  • Author(s): 島野仁
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2014-10-16
  • Invited
• [Presentation] A new aspect of organ lipids in metabolic diseases, lessons from Elovl6. (2014)
  • Author(s): Hitosh Shimano
  • Organizer: Homeodynamics in Clocks, Sleep and Metabolism ―Tokyo Tanslational therapeutics meeting
  • Place of Presentation: Ito Hall, Ito Internatonal Research Center, The University of Tokyo
  • Year and Date: 2014-09-24
  • Invited
• [Presentation] New Aspect of Organ Lipids in Metablic Diseases and Atherosclerosis from Quantity to Quality: Lessons from Elovl6. (2014)
  • Author(s): Hitoshi Shimano
  • Organizer: 9th Metablic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2014-09-12 – 2014-09-14
  • Invited
• [Remarks] 筑波大学 内分泌代謝・糖尿病内科
  • URL: http://www.u-tsukuba-endocrinology.jp/