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GLP-1 and insulin synergize to activate vagal afferent nerves leading to central regulation of metabolism, feeding and blood pressure

Research Project

Project/Area Number 26670453
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionJichi Medical University

Principal Investigator

YADA Toshihiko  自治医科大学, 医学部, 教授 (60166527)

Co-Investigator(Kenkyū-buntansha) 岩崎 有作  自治医科大学, 医学部, 講師 (60528420)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsインスリン / GLP-1 / 求心性迷走神経 / 糖代謝 / 摂食
Outline of Final Research Achievements

GLP-1 and insulin increased cytosolic Ca2+ ([Ca2+]) in isolated neurons form vagal afferents. GLP-1 and insulin, at low concentrations incapable of inducing [Ca2+] responses, in combination either induced [Ca2+] increases with greater amplitude in responsive neurons or produced [Ca2+] increases in unresponsive neurons, showing additive or synergistic effects. We found a sugar that induced both GLP-1 and insulin release. This sugar suppressed food intake and promoted glucose tolerance, and when chronically administered it ameliorated hyperphagia, obesity and glucose intolerance. All these effects were inhibited in GLP-1 receptor KO mice and by vagotomy.
These data suggest that GLP-1 and insulin act synergistically to activate vagal afferent neurons and regulate metabolism.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (47 results)

All 2017 2016 2015 2014

All Journal Article (15 results) (of which Peer Reviewed: 15 results,  Open Access: 14 results,  Acknowledgement Compliant: 8 results) Presentation (31 results) (of which Int'l Joint Research: 4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Endogenous α2A-adrenoceptor-operated sympathoadrenergic tones attenuate insulin secretion via cAMP/TRPM2 signaling.2017

    • Author(s)
      Ito K, Dezaki K, Yoshida M, Yamada H, Miura R, Rita RS, Ookawara S, Tabei K, Kawakami M, Hara K, Morishita Y, Yada T, Kakei M
    • Journal Title

      Diabetes

      Volume: 66(3) Issue: 3 Pages: 699-709

    • DOI

      10.2337/db16-1166

    • NAID

      40021363366

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suprachiasmatic Vasopressin to Paraventricular Oxytocin Neurocircuit in the Hypothalamus Relays Light Reception to Inhibition of Feeding Behavior.2017

    • Author(s)
      Santoso P, Nakata M, Ueta Y, Toshihiko Yada T
    • Journal Title

      Am J Physiol Endocrinol Metab.

      Volume: 印刷中 Issue: 4 Pages: E478-E488

    • DOI

      10.1152/ajpendo.00338.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis.2017

    • Author(s)
      Sasanuma H, Nakata M, Kumari P, Nakae J, Yada T
    • Journal Title

      Molecular Metabolism

      Volume: 6(5) Issue: 5 Pages: 428-439

    • DOI

      10.1016/j.molmet.2017.02.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Potentiation of Glucose-stimulated Insulin Secretion by GPR40-PLC-TRPC Pathway in Pancreatic β-Cells2016

    • Author(s)
      Hodaka Yamada, Masashi Yoshida, Kiyonori Ito, Katsuya Dezaki, Toshihiko Yada, San-e Ishikawa, Masafumi Kakei
    • Journal Title

      Scientific reports

      Volume: 6 Issue: 1 Pages: 25912-25912

    • DOI

      10.1038/srep25912

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Total gastrectomy-induced reductions in food intake and weight are counteracted by rikkunshito by attenuating glucagon-like peptide-1 elevation in rats.2016

    • Author(s)
      taguchi Masanobu
    • Journal Title

      Surgery

      Volume: 159 Issue: 5 Pages: 1342-1350

    • DOI

      10.1016/j.surg.2015.12.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Paraventricular NUCB2/Nesfatin-1 Supports Oxytocin and Vasopressin Neurons to Control Feeding Behavior and Fluid Balance in Male Mice.2016

    • Author(s)
      Nakata M, Gantulga D, Santoso P, Zhang B, Masuda C, Mori M, Okada T, Yada T
    • Journal Title

      Endocrinology

      Volume: 157 Issue: 6 Pages: 2322-2332

    • DOI

      10.1210/en.2015-2082

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optogenetic activation of leptin- and glucoseregulated GABAergic neurons in dorsomedial hypothalamus promotes food intake via inhibitory synaptic transmission to paraventricular nucleus of hypothalamus.2016

    • Author(s)
      Zesemdorj Otgon-Uul , Shigetomo Suyama, Hiroshi Onodera, Toshihiko Yada.
    • Journal Title

      Molecular Metabolism

      Volume: 5 Issue: 8 Pages: 709-715

    • DOI

      10.1016/j.molmet.2016.06.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ghrelin counteracts insulin-induced activation of vagal afferent neurons via growth hormone secretagogue receptor.2015

    • Author(s)
      Iwasaki, Y., Dezaki, K., Kumari, P., Kakei, M., and Yada, T.
    • Journal Title

      Neuropeptide

      Volume: 52 Pages: 55-60

    • DOI

      10.1016/j.npep.2015.06.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Partial Blockade of Kv2.1 Channel Potentiates GLP-1's Insulinotropic Effects in Islets and Reduces Its Dose Required for Improving Glucose Tolerance in Type 2 Diabetic Male Mice.2015

    • Author(s)
      Sukma Rita, R., K. Dezaki, T. Kurashina, M. Kakei, and T. Yada,
    • Journal Title

      Endocrinology.

      Volume: Endocrinology. 1(1): Issue: 1 Pages: 114-123

    • DOI

      10.1210/en.2014-1728

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Paraventricular NUCB2/nesfatin-1 is directly targeted by leptin and mediates its anorexigenic effect2015

    • Author(s)
      Darambazar G, Nakata M, Okada T, Wang L, Li E, Shinozaki A, Motoshima M, Mori M, Yada T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 456(4) Issue: 4 Pages: 913-918

    • DOI

      10.1016/j.bbrc.2014.12.065

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity.2015

    • Author(s)
      Iwasaki, Y., Y. Maejima, S. Suyama, M. Yoshida, T. Arai, K. Katsurada, P. Kumari, H. Nakabayashi, M. Kakei, and T. Yada,
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 308 Issue: 5 Pages: R360-R369

    • DOI

      10.1152/ajpregu.00344.2014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Glucagon directly interacts with vagal afferent nodose ganglion neurons to induce Ca(2+) signaling via glucagon receptors.2015

    • Author(s)
      Ayush EA, Iwasaki Y, Iwamoto S, Nakabayashi H, Kakei M, Yada T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 456 Issue: 3 Pages: 727-732

    • DOI

      10.1016/j.bbrc.2014.12.031

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nasal oxytocin administration reduce food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas.2015

    • Author(s)
      Maejima Y, Rita RS, Santoso P, Aoyama M, Hiraoka Y, Nishimori K, Gantulga D, Shimomura K, Yada T
    • Journal Title

      Neuroendocrinology

      Volume: 101 Issue: 1 Pages: 35-44

    • DOI

      10.1159/000371636

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons.2014

    • Author(s)
      Katsurada K, Maejima Y, Nakata M, et al.
    • Journal Title

      iochem Biophys Res Commun.

      Volume: 451 Issue: 2 Pages: 276-281

    • DOI

      10.1016/j.bbrc.2014.07.116

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcute POMC neurons.2014

    • Author(s)
      Maejima Y, Sakuma S, Santoso P, Gantulga D, Katsurada K, Ueta Y, Hiraoka Y, Nishimori K, Tanaka S, Shimomura K, Yada T
    • Journal Title

      FEBS Letter

      Volume: 588 Issue: 23 Pages: 4404-4412

    • DOI

      10.1016/j.febslet.2014.10.010

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 希少糖アルロースによるGLP-1放出、求心性迷走神経を介した摂食・糖代謝制御と肥満症改善.2017

    • Author(s)
      矢田俊彦,岩﨑有作,比良徹,原博,Goswami Chayon,仙度光麻,徳田雅明,出崎克也
    • Organizer
      第122回日本解剖学会総会・全国学術集会(日本解剖学会・日本生理学会合同シンポジウム)
    • Place of Presentation
      長崎大学坂本キャンパス(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 希少糖D-Allulose摂取はGLP-1分泌促進と求心性迷走神経の活性化を介して摂食を抑制し、耐糖能を向上させる.2017

    • Author(s)
      岩崎有作,Goswami Chayon,仙度光麻,出崎克也,比良徹,原博,徳田雅明,矢田俊彦
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 短鎖脂肪酸のブタン酸は求心性迷走神経を介して摂食量を抑制する.2017

    • Author(s)
      Goswami Chayon,岩崎有作,矢田俊彦
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] オキシトシンはGq-非選択的カチオンチャネル活性化によりβ細胞インスリン分泌を促進する.2017

    • Author(s)
      出崎克也,三浦李菜,矢田俊彦
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Central GLP-1 receptor agonist promotes insulin release and lowers blood glucose.2017

    • Author(s)
      Parmila Kumari, Masanori Nakata, Zesemdorj Otgonuul, Zhang Boyang, Toshihiko Yada
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] D-Allulose stimulates GLP-1 release and vagal afferents to correct feeding disorder, visceral obesity and hyperglycemia in obese mice.2016

    • Author(s)
      Iwasaki Y, Kumari P, Hira T, Dezaki K, Goswami C, Hara H, Tokuda M, Yada T
    • Organizer
      6th Symposium of International Society of Rare Sugars
    • Place of Presentation
      Kagawa International Conference Hall (Takamatsu, Kagawa, Japan)
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 希少糖Allulose摂取によるGLP-1分泌は過食、摂食リズム障害、肥満を改善する.2016

    • Author(s)
      岩崎有作,Parmila Kumari,比良徹,荒井健,出崎克也,原博,徳田雅明,矢田俊彦
    • Organizer
      第37回日本肥満学会
    • Place of Presentation
      東京ファッションタウンビル(東京都江東区)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] オキシトシンによる膵β細胞活性化とインスリン分泌促進.2016

    • Author(s)
      三浦李菜,出崎克也,矢田俊彦
    • Organizer
      第37回日本肥満学会
    • Place of Presentation
      東京ファッションタウンビル(東京都江東区)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] ゼロカロリー甘味料である希少糖D-AlluloseはGLP-1分泌と迷走神経活性化を介して糖尿病・過食・肥満を改善する.2016

    • Author(s)
      岩崎有作,荒井健,Parmila Kumari,出崎克也,比良徹,原博,徳田雅明,矢田俊彦
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館、他(京都府京都市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] グレリンのインスリン分泌・糖代謝作用における膵β細胞 vs 全身GHS-Rの役割.2016

    • Author(s)
      出崎克也,倉科智行,吉田昌史,加計正文,矢田俊彦
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館、他(京都府京都市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] アドレナリンによるβ細胞背景電流抑制によるインスリン分泌抑制作用.2016

    • Author(s)
      伊藤聖学,吉田昌史,山田穂高,出崎克也,大河原晋,田部井薫,川上正舒,森下義幸,矢田俊彦,加計正文
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館、他(京都府京都市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 膵β細胞における脂肪酸受容体GPR40を介する新規インスリン分泌メカニズム.2016

    • Author(s)
      山田穂高,吉田昌史,伊藤聖学,出崎克也,川上正舒,石川三衛,矢田俊彦,加計正文
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館、他(京都府京都市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 膵β細胞におけるピルビン酸カルボキシラーゼは,インスリンの基礎分泌に重要である.2016

    • Author(s)
      大平理沙,中江淳,小谷紀子,中田正範,川野義長,菊地徹洋,松崎素子,後藤伸子,茂田文子,八木一騎,矢田俊彦,伊藤裕
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館、他(京都府京都市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 玄米由来機能成分γ-オリザノールによるドパミン受容体シグナルを介するグルコース応答性インスリン分泌増強の新規メカニズム.2016

    • Author(s)
      小塚智沙代,砂川澄人,植田玲,比嘉盛丈,池間朋己,田仲秀明,清水千草,高山千利,松下正之,中田正範,矢田俊彦,親泊政一,島袋充生,益崎裕章
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館、他(京都府京都市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 空腹時の食欲創出機構:低血糖-弓状核ATP-Na+ポンプ-NPY/AgRPニューロン経路の解明.2016

    • Author(s)
      矢田俊彦,栗田英治,Putra Santoso,楊怡飛,出崎克也,中田正範
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館、他(京都府京都市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 視床下部弓状核Na+,K+-ATPaseはグルコセンサーとして摂食行動を制御する2016

    • Author(s)
      矢田俊彦,栗田英治,中田正範
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] TRPA1アゴニストによる摂食促進:摂食亢進性の新規求心性迷走神経サブグループの関与2016

    • Author(s)
      岩崎有作,矢田俊彦
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] グルカゴンによる求心性迷走神経の活性化:中枢作用を仲介する伝達経路2015

    • Author(s)
      岩崎有作,岩本禎彦,加計正文,矢田俊彦
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Presentation] Na+, K+-ATPase in the arcuate nucleus senses systemic energy states to regulate feeding behavior.2015

    • Author(s)
      Yada T, Kurita H, Nakata M
    • Organizer
      The 46th NIPS International Symposium
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Peripheral oxytocin administration activates vagal afferent nervesto suppress feeding, ameliorating hyperphagia and obesity in diabetic db/db mice.2015

    • Author(s)
      Yada T, Iwasaki Y, Maejima Y, Suyama S, Yoshida M, Arai T, Katsurada K, Kumari P, Kakei M
    • Organizer
      51st EASD Annual Meeting
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2015-09-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] GLP-1 and insulin synergistically activate vagal afferent nodose ganglion neurons.2015

    • Author(s)
      Yada T, Iwasaki Y
    • Organizer
      Incretin 2015. A Symposium Celebrating the 45th Anniversary of the Discovery of GIP
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2015-07-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] グルカゴンはグルカゴン受容体を介して求心性迷走神経を活性化する2015

    • Author(s)
      岩﨑有作,Enkh-Amar Ayush,岩本禎彦,中林肇,加計正文,矢田俊彦
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 室傍核NUCB2/Nesfatin-1ノックダウンマウスの解析:摂食概日リズム障害と内臓肥満2015

    • Author(s)
      王磊,中田正範,矢田俊彦
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 末梢オキシトシン→求心性迷走神経→脳」軸の活性化による過食・肥満抑制2015

    • Author(s)
      岩﨑有作,前島裕子,吉田昌史,須山成朝,加計正文,矢田俊彦
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 視床下部弓状核POMC, NPY ニューロンに対するアディポネクチンの作用機序.2015

    • Author(s)
      須山成朝,窪田直人,門脇孝,矢田俊彦
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Kv2.1チャネル阻害はGLP-1 誘発インスリン分泌を増強し2 型糖尿病の耐糖能を改善する.2015

    • Author(s)
      出崎克也,Rita Rauza Sukma,加計正文,矢田俊彦
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] グルカゴンは求心性迷走神経に直接作用し活性化させる:摂食調節への役割.2015

    • Author(s)
      Enkh-Amar Ayush,岩﨑有作,岩本禎彦,矢田俊彦
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 末梢Oxytocin は求心性迷走神経を活性化して摂食を抑制する.2015

    • Author(s)
      岩崎有作,前島裕子,吉田昌史,荒井健,須山成朝,桂田健一,中林肇,加計正文,矢田俊彦
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 室傍核NUCB2/nesfatin-1ニューロンによる摂食調節.2015

    • Author(s)
      中田正範,Darambazar Gantulga,王磊,矢田俊彦
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Central Glucagon-like peptide-1 Receptor Activation Counteracts Hypertension with Suppression of Sympathetic Nerve Activity in Spontaneously Hypertensive Rats.2014

    • Author(s)
      Katsurada K, Maejima Y, Nakata M, Yada T, Kario K
    • Organizer
      American Heart Association, SCIENTIFIC SESSIONS 20014
    • Place of Presentation
      CHICAGO, ILLINOIS, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] インスリンによる求心性迷走神経の活性化と過食・肥満・糖尿病を呈するIRS2欠損マウスにおけるその障害.2014

    • Author(s)
      岩﨑有作,下村健寿,河野大輔,出崎克也,Ayush Enkh-Amar,中林肇,窪田直人,門脇孝,加計正文,中田正範,矢田俊彦
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] GLP-1分泌促進剤2015

    • Inventor(s)
      矢田俊彦、岩崎有作、原博、比良徹、岸本由香、南真知子
    • Industrial Property Rights Holder
      自治医科大学、北海道大学、松谷化学工業株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-149634
    • Filing Date
      2015-07-29
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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