GLP-1 and insulin synergize to activate vagal afferent nerves leading to central regulation of metabolism, feeding and blood pressure
Project/Area Number |
26670453
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
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Research Institution | Jichi Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
岩崎 有作 自治医科大学, 医学部, 講師 (60528420)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | インスリン / GLP-1 / 求心性迷走神経 / 糖代謝 / 摂食 |
Outline of Final Research Achievements |
GLP-1 and insulin increased cytosolic Ca2+ ([Ca2+]) in isolated neurons form vagal afferents. GLP-1 and insulin, at low concentrations incapable of inducing [Ca2+] responses, in combination either induced [Ca2+] increases with greater amplitude in responsive neurons or produced [Ca2+] increases in unresponsive neurons, showing additive or synergistic effects. We found a sugar that induced both GLP-1 and insulin release. This sugar suppressed food intake and promoted glucose tolerance, and when chronically administered it ameliorated hyperphagia, obesity and glucose intolerance. All these effects were inhibited in GLP-1 receptor KO mice and by vagotomy. These data suggest that GLP-1 and insulin act synergistically to activate vagal afferent neurons and regulate metabolism.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Endogenous α2A-adrenoceptor-operated sympathoadrenergic tones attenuate insulin secretion via cAMP/TRPM2 signaling.2017
Author(s)
Ito K, Dezaki K, Yoshida M, Yamada H, Miura R, Rita RS, Ookawara S, Tabei K, Kawakami M, Hara K, Morishita Y, Yada T, Kakei M
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Journal Title
Diabetes
Volume: 66(3)
Issue: 3
Pages: 699-709
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity.2015
Author(s)
Iwasaki, Y., Y. Maejima, S. Suyama, M. Yoshida, T. Arai, K. Katsurada, P. Kumari, H. Nakabayashi, M. Kakei, and T. Yada,
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Journal Title
Am J Physiol Regul Integr Comp Physiol.
Volume: 308
Issue: 5
Pages: R360-R369
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcute POMC neurons.2014
Author(s)
Maejima Y, Sakuma S, Santoso P, Gantulga D, Katsurada K, Ueta Y, Hiraoka Y, Nishimori K, Tanaka S, Shimomura K, Yada T
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Journal Title
FEBS Letter
Volume: 588
Issue: 23
Pages: 4404-4412
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] D-Allulose stimulates GLP-1 release and vagal afferents to correct feeding disorder, visceral obesity and hyperglycemia in obese mice.2016
Author(s)
Iwasaki Y, Kumari P, Hira T, Dezaki K, Goswami C, Hara H, Tokuda M, Yada T
Organizer
6th Symposium of International Society of Rare Sugars
Place of Presentation
Kagawa International Conference Hall (Takamatsu, Kagawa, Japan)
Year and Date
2016-11-24
Related Report
Int'l Joint Research
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[Presentation] Peripheral oxytocin administration activates vagal afferent nervesto suppress feeding, ameliorating hyperphagia and obesity in diabetic db/db mice.2015
Author(s)
Yada T, Iwasaki Y, Maejima Y, Suyama S, Yoshida M, Arai T, Katsurada K, Kumari P, Kakei M
Organizer
51st EASD Annual Meeting
Place of Presentation
Stockholm, Sweden
Year and Date
2015-09-14
Related Report
Int'l Joint Research
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