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Provocative epidemiological study on identification of factor of thyroid carcinogenesis

Research Project

Project/Area Number 26670460
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Endocrinology
Research InstitutionNagasaki University

Principal Investigator

YAMASHITA Shunichi  長崎大学, 原爆後障害医療研究所, 教授 (30200679)

Co-Investigator(Kenkyū-buntansha) TAKAMURA Noboru  長崎大学, 原爆後障害医療研究所, 教授 (30295068)
MITSUTAKE Norisato  長崎大学, 原爆後障害医療研究所, 准教授 (50404215)
SAENKO Vladimir  長崎大学, 原爆後障害医療研究所, 准教授 (30343346)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords環境 / 放射線 / 内分泌学 / 甲状腺癌
Outline of Final Research Achievements

Besides the risk of thyroid cancer due to internal exposure of radioactive iodine, clarified after the Chernobyl NPP accident, nitrate and nitrite are potent carcinogens that cause cancers and suggests to be related to increased incidence of thyroid cancer in the world. Therefore, we have analyzed the data obtained from Belarus such as geographical distribution of thyroid cancer, radioiodine contaminated map together and nitrate concentration in drinking water, which results are jointly published as the English review paper.
In Fukushima after the NPP accident, a high detection rate of thyroid abnormalities screened by thyroid ultrasound may be linked to such level of nitrates but after measurement in Kawauchi village, where are all inhabitants use their own private well as the main source of drinking water, all samples showed no abnormal finding. Our preliminary data suggest that nitrate in drinking water dose not contribute significantly to thyroid disorders in Kawauchi village.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2015 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (4 results) (of which Invited: 2 results) Remarks (2 results)

  • [Int'l Joint Research] 卒後医学教育アカデミー/Valentina Drozd(ベラルーシ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Bipolarization of Risk Perception about the Health Effects of Radiation in Residents after the Accident at Fukushima Nuclear Power Plant.2015

    • Author(s)
      Orita M, Hayashida N, Nakayama Y, Shinkawa T, Urata H, Fukushima Y, Endo Y, Yamashita S, Takamura N
    • Journal Title

      PLoS one

      Volume: 10(6)

    • NAID

      120006987000

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Post-crisis efforts towards recovery and resilience after the Fukushima Daiichi Nuclear Power Plant accident.2015

    • Author(s)
      Yamashita S, Takamura N
    • Journal Title

      Jpn J Clin Oncol

      Volume: 45(8) Pages: 700-707

    • NAID

      120006986956

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Implication of nitrate in drinking water in Kawauchi village, Fukushima.2015

    • Author(s)
      Orita M, Iyama K, HayashidaN, Mitsutake N, Suzuki S, Yamashita S, Takamura N
    • Journal Title

      Thyroid

      Volume: 25(9) Pages: 1064-1065

    • NAID

      120006986928

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Major Factors Affecting Incidence of Childhood Thyroid Cancer in Belarus after the Chernobyl Accident: Do Nitrates in Drinking Water Play a Role?2015

    • Author(s)
      Drozd VM, Saenko VA, Brenner AV, Drozdovitch V, Pashkevich VI, Kudelsky AV, Demidchik YE, Branovan I, Shiglik N, Rogounovitch TI, Yamashita S, Biko J, Reiners C
    • Journal Title

      PLoS One

      Volume: 10(9)

    • NAID

      120006986839

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Measurement of Individual Doses of Radiation by Personal Dosimeter is Important for the Return of Residents from Evacuation Order Areas after Nuclear Disaster.2015

    • Author(s)
      Orita M, Hayashida N, Taira Y, Fukushima Y, Ide J, Endo Y, Kudo T, Yamashita S, Takamura N
    • Journal Title

      PLoS One

      Volume: 10(3) Issue: 3 Pages: e0121990-e0121990

    • DOI

      10.1371/journal.pone.0121990

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 福島県住民における発がんをはじめとするリスク認知について2015

    • Author(s)
      折田真紀子、林田直美、新川哲子、浦田秀子、福島芳子、遠藤雄幸、山下俊一、高村昇
    • Organizer
      第58回日本甲状腺学会学術集会
    • Place of Presentation
      福島県文化センター(福島県福島市)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 甲状腺腫瘍と硝酸・亜硝酸窒素動態との関係2015

    • Author(s)
      井山慶大、折田真紀子、林田直美、光武範吏、サエンコ ウラジミール、ログノビッチ タチアナ、高村昇、鈴木眞一、ドロズド ワレンチナ、山下俊一
    • Organizer
      第58回日本甲状腺学会学術集会
    • Place of Presentation
      福島県文化センター(福島県福島市)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 放射線と甲状腺-震災から4年半を経過して-2015

    • Author(s)
      山下俊一
    • Organizer
      第58回日本甲状腺学会学術集会
    • Place of Presentation
      福島県文化センター(福島県福島市)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 放射線被ばくと甲状腺がんリスク2015

    • Author(s)
      山下俊一
    • Organizer
      第29回日本医学会総会2015関西
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2015-04-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Remarks] 長崎大学原研医療ホームページ

    • URL

      http://www-sdc.med.nagasaki-u.ac.jp/drms/member.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 長崎大学 原研医療ホームページ

    • URL

      http://www.med.nagasaki-u.ac.jp/adi-pphy/index.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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