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Regulation of plasma histamine levels by the mast cell clock

Research Project

Project/Area Number 26670475
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionUniversity of Yamanashi

Principal Investigator

NAKAO Atsuhito  山梨大学, 総合研究部, 教授 (80317445)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsアレルギー / ヒスタミン / マスト細胞 / 概日時計 / 血漿ヒスタミン濃度 / 定常状態 / 時計遺伝子 / ヒスタミン合成酵素
Outline of Final Research Achievements

At steady state, plasma histamine levels exhibit circadian variations with nocturnal peaks, which are implicated in the nighttime exacerbation of allergic symptoms. This study determined how steady-state plasma histamine levels are regulated and affectedcation transporter 3 (OCT3), which is involved in histamine transport, in mast cells; OCT inhibition abolished circadian variations in plasma histamine levels. Collectively, the mast cell clock by environmental factors. Plasma histamine levels decreased in mast cell-deficient mice and their circadian variations were lost in mast cell-deficient mice reconstituted with bone marrow-derived mast cells (BMMCs) harboring a mutation in the circadian gene Clock. Clock temporally regulates expression of organic mediates circadian regulation of plasma histamine levels at steady state, in part by controlling OCT3 expression.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (20 results)

All 2016 2015 2014 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 12 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Remarks (1 results)

  • [Journal Article] The Alarmin IL-33 Derived from HSV-2-Infected Keratinocytes Triggers Mast Cell-Mediated Antiviral Innate Immunity.2016

    • Author(s)
      Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Moriishi K, Nakao A, Shimada S
    • Journal Title

      J Invest Dermatol

      Volume: 印刷中 Issue: 6 Pages: 1290-1292

    • DOI

      10.1016/j.jid.2016.01.030

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation.2016

    • Author(s)
      Matsuoka S, Ishii Y, Nakao A, Abe M, Ohtsuji N, Momose S, Jin H, Arase H, Sugimoto K, Nakauchi Y, Masutani H, Maeda M, Yagita H, Komatsu N, Hino O
    • Journal Title

      PLoS One

      Volume: 11 Issue: 3 Pages: e0150496-e0150496

    • DOI

      10.1371/journal.pone.0150496

    • NAID

      120005838168

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock.2015

    • Author(s)
      Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A
    • Journal Title

      The Journal of allergy and clinical immunology

      Volume: 137(4) Issue: 4 Pages: 1226-1235

    • DOI

      10.1016/j.jaci.2015.08.052

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model.2015

    • Author(s)
      Tanabe K, Kitagawa E, Wada M, Haraguchi A, Orihara K, Tahara Y, Nakao A, Shibata S.
    • Journal Title

      Sci Rep.

      Volume: 5 Issue: 1 Pages: 14424-14424

    • DOI

      10.1038/srep14424

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice.2015

    • Author(s)
      Ando N, Nakamura Y, Aoki R, Ishimaru K, Ogawa H, Okumura K, Shibata S, Shimada S, Nakao A
    • Journal Title

      J Invest Dermatol

      Volume: 135 Issue: 12 Pages: 3001-3008

    • DOI

      10.1038/jid.2015.316

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-7: AhR We Ready for a New Cytokine to Fight Colitis?2015

    • Author(s)
      Nakao A
    • Journal Title

      Dig Dis Sci

      Volume: 60 Issue: 7 Pages: 1876-1877

    • DOI

      10.1007/s10620-015-3721-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Positive association between serum thymic stromal lymphopoietin and anti-citrullinated peptide antibodies in patients with rheumatoid arthritis.2015

    • Author(s)
      Koyama K, Ohba T, Haro H, Nakao A
    • Journal Title

      Clin Exp Immunol

      Volume: 181 Issue: 2 Pages: 239-243

    • DOI

      10.1111/cei.12632

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synergistic antitumor effect with indoleamine 2,3-dioxygenase inhibition and temozolomide in a murine glioma model.2015

    • Author(s)
      Hanihara M, Kawataki T, Oh-oka K, Mitsuka K, Nakao A, Kinouchi H
    • Journal Title

      Journal of Neurosurgery

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Cricadian Clock Functions As A Potent Regulator of Allergic Reaction. [Review]2015

    • Author(s)
      Nakao A, Nakamura Y, Shibata S
    • Journal Title

      Allergy

      Volume: 70(5) Issue: 5 Pages: 467-473

    • DOI

      10.1111/all.12596

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis.2015

    • Author(s)
      Ando N, Nakamura Y, Ishimaru K, Ogawa H, Okumura K, Shimada S, Nakao A
    • Journal Title

      Allergy

      Volume: 70(3) Issue: 3 Pages: 319-322

    • DOI

      10.1111/all.12552

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disruption of the Suprachiasmatic Nucleus Blunts A Time of Day-Dependent Variation in Systemic2014

    • Author(s)
      Nakamura Y, Ishimaru K, Tahara Y, Shibata S, Nakao A
    • Journal Title

      Journal of Immunology Research

      Volume: vol.2014 Pages: 474217-474217

    • DOI

      10.1155/2014/474217

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circadian regulation of allergic reaction by the mast cell clock in mice.2014

    • Author(s)
      Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R,
    • Journal Title

      J Allergy Clin Immun

      Volume: 133(2) Pages: 1-4

    • DOI

      10.1155/2014/614529

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The mast cell-clock regulates blood histamine levels: implication for stress-induced exacerbation of allergy.2016

    • Author(s)
      Nakao A
    • Organizer
      31th symposium of the Collegium Internationale Allergologicum
    • Place of Presentation
      Charleston, USA
    • Year and Date
      2016-04-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Inhibition of IgE-Mediated Allergic Reaction By Pharmacologically Targeting the Circadian Clock.2016

    • Author(s)
      Nakamura Y, Shibata S, Nakao A
    • Organizer
      2016 AAAAI Annual Meeting
    • Place of Presentation
      Los Angeles, USA
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Allergy:From Bench to Bedside and Beyond.2015

    • Author(s)
      Nakao A
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] スギ花粉症患者好塩基球のスギ花粉に対する反応性の日内変動2015

    • Author(s)
      安藤典子,中村勇規,石丸かよ子,島田眞路,中尾篤人
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] IL-33依存性マスト細胞応答は時計遺伝子Clockにより制御される2015

    • Author(s)
      河内貴広,中村勇規,中尾篤人
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] レスベラトロール二量体であるε-ビニフェリンによるIgE依存性アレルギー反応の抑制効果2015

    • Author(s)
      齋藤一歩,大岡杏子,久本雅嗣,奥田徹,中尾篤人
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Temporal regulation of allergic reaction by the circadian clock.アレルギーと概日時計.2014

    • Author(s)
      中尾篤人
    • Organizer
      第21回日本時間生物学会学術大会
    • Place of Presentation
      九州大学(福岡県)
    • Year and Date
      2014-11-07 – 2014-11-09
    • Related Report
      2014 Research-status Report
    • Invited
  • [Remarks] 山梨大学医学部免疫学講座ホームページ

    • URL

      http://www.med.yamanashi.ac.jp/clinical_basic/para0imm/kenkyuu/kenkyuu.php

    • Related Report
      2015 Annual Research Report 2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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