Regulation of plasma histamine levels by the mast cell clock
| Project/Area Number |
26670475
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アレルギー / ヒスタミン / マスト細胞 / 概日時計 / 血漿ヒスタミン濃度 / 定常状態 / 時計遺伝子 / ヒスタミン合成酵素 |
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| Outline of Final Research Achievements |
At steady state, plasma histamine levels exhibit circadian variations with nocturnal peaks, which are implicated in the nighttime exacerbation of allergic symptoms. This study determined how steady-state plasma histamine levels are regulated and affectedcation transporter 3 (OCT3), which is involved in histamine transport, in mast cells; OCT inhibition abolished circadian variations in plasma histamine levels. Collectively, the mast cell clock by environmental factors. Plasma histamine levels decreased in mast cell-deficient mice and their circadian variations were lost in mast cell-deficient mice reconstituted with bone marrow-derived mast cells (BMMCs) harboring a mutation in the circadian gene Clock. Clock temporally regulates expression of organic mediates circadian regulation of plasma histamine levels at steady state, in part by controlling OCT3 expression.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation.2016
Author(s)
Matsuoka S, Ishii Y, Nakao A, Abe M, Ohtsuji N, Momose S, Jin H, Arase H, Sugimoto K, Nakauchi Y, Masutani H, Maeda M, Yagita H, Komatsu N, Hino O
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Journal Title
PLoS One
Volume: 11
Issue: 3
Pages: e0150496-e0150496
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock.2015
Author(s)
Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A
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Journal Title
The Journal of allergy and clinical immunology
Volume: 137(4)
Issue: 4
Pages: 1226-1235
DOI
Related Report
Peer Reviewed / Open Access
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