| Project/Area Number |
26670475
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アレルギー / ヒスタミン / マスト細胞 / 概日時計 / 血漿ヒスタミン濃度 / 定常状態 / 時計遺伝子 / ヒスタミン合成酵素 |
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| Outline of Final Research Achievements |
At steady state, plasma histamine levels exhibit circadian variations with nocturnal peaks, which are implicated in the nighttime exacerbation of allergic symptoms. This study determined how steady-state plasma histamine levels are regulated and affectedcation transporter 3 (OCT3), which is involved in histamine transport, in mast cells; OCT inhibition abolished circadian variations in plasma histamine levels. Collectively, the mast cell clock by environmental factors. Plasma histamine levels decreased in mast cell-deficient mice and their circadian variations were lost in mast cell-deficient mice reconstituted with bone marrow-derived mast cells (BMMCs) harboring a mutation in the circadian gene Clock. Clock temporally regulates expression of organic mediates circadian regulation of plasma histamine levels at steady state, in part by controlling OCT3 expression.
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