• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Epigenetic analysis of selective control of IL-17 production, and search for new strategy to treat chronic inflammation in collagen-diseases.

Research Project

Project/Area Number 26670476
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionKyoto University

Principal Investigator

Usui Takashi  京都大学, 医学(系)研究科(研究院), その他 (90362483)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsGM-CSF / IL-17 / エピゲノム制御 / ヘルパーT細胞 / 間質性肺炎 / サイトカイン
Outline of Final Research Achievements

IL-17 and the GM-CSF are important cytokines to maintain chronic inflammation of collagen diseases. In this project, we analyzed the mechanisms of production in-vitro and the treatment/intervention effects in-vivo of these cytokines.First, we established murine T cell clones which produce large amount of IL-17, and non-producer clones also. We found that gene-X controlled it through the methylation of the GC island of the IL-17 promoter domain. Second, we analyzed function of IL-17- and GM-CSF-producing cells using chronic/progressive interstitial pneumonitis model (SKG+zaymosan). We found the contribution of IL-17 was relatively low and GM-CSF was essential of this model. These findings suggest the new strategies to treat human collagen diseases which are un-met.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 4 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] A novel splice variant of human L-selectin encodes a soluble molecule that is elevated in serum of patients with rheumatic diseases2015

    • Author(s)
      Hirata T, Usui T, Kobayashi S, Mimori T
    • Journal Title

      Biochemical Biophysical Research Communications

      Volume: 462 Issue: 4 Pages: 371-377

    • DOI

      10.1016/j.bbrc.2015.05.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.2015

    • Author(s)
      Shiomi A, Usui T, Ishikawa Y, Shimizu M, Murakami K, Mimori T.
    • Journal Title

      J Immunol

      Volume: 193 Pages: 849-859

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pivotal roles of GM-CSF in autoimmunity and inflammation.2015

    • Author(s)
      Shiomi A, Usui T.
    • Journal Title

      Mediators Inflamm

      Volume: 0 Issue: 1 Pages: 0-0

    • DOI

      10.1155/2015/568543

    • NAID

      120005745654

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Functional engraftment of human peripheral T and B cells and sustained production of autoantibodies in NOD/LtSzscid/ IL-2Rγ-/- mice.2014

    • Author(s)
      Ishikawa Y, Usui T, Shiomi A, Shimizu M, Murakami K, Mimori T
    • Journal Title

      Eur J Immunol.

      Volume: 44(11) Issue: 11 Pages: 3453-3463

    • DOI

      10.1002/eji.201444729

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.2014

    • Author(s)
      Shiomi A, Usui T, Ishikawa Y, Shimizu M, Murakami K, Mimori T
    • Journal Title

      J Immunol

      Volume: 193(2) Issue: 2 Pages: 849-859

    • DOI

      10.4049/jimmunol.1303255

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] GM-CSFと自己免疫疾患:関節炎合併間質性肺炎モデルを中心に2015

    • Author(s)
      塩見  葵,臼井  宗,三森 経世
    • Organizer
      第36回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-21
    • Related Report
      2015 Annual Research Report
    • Invited

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi