| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, we identified TNFRSF18 as a specific surface molecule for the regulation of GM-CSF by activated Th cells in vitro. The activation of TNFRSF18 signaling also induced GM-CSF production from effector/memory Th cells in vivo, indicating that this signal cascade is a key molecular pathway to specifically enhance production of GM-CSF. Furthermore, TNFSF18-deficient mice were resistant to the development of experimental autoimmune encephalomyelitis, accompanying impaired production of GM-CSF by tissue infiltrating pathogenic Th cells. Thus, targeting this molecular pathway may be useful for a therapeutic means to prevent or treat the autoimmune disease.
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