Analysis of mechanisms of rheumatoid arthritis associated with obesity
| Project/Area Number |
26670479
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | Tokyo Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | リウマチ / 肥満 / シノビオリン / 阻害剤 / 脂肪 / 小胞体ストレス |
|---|
| Outline of Final Research Achievements |
Obesity was related to the increase of risk of the rheumatic onset. However, the molecular mechanism is not clear. We demonstrated that synoviolin (SYVN1) was important in rheumatoid arthritis (RA) and obesity. We showed that SYVN1 was causing factor of RA and SYVN1 inhibitor repressed RA in collagen-induced arthritis mice model. We recently demonstrated that Syvn1 knockoutl mice was associated with weight loss and reduced white adipose tissue abundance. In this study, we investigated the expression of SYVN1 in the obesity. SYVN1 was highly expressed in the obese mice (ob/ob and db/db mice) and obese human. We next examined the effects of SYVN1 inhibitor. SYVN1 inhibitors prevented age-related weight gain in wild-type mice and obese mice. In addition, reduction of white adipose tissue was observed. We found inhibitory effects of SYVN1 in natural products. Our findings indicate the potential usefulness of SYVN1 inhibitor in preventing and treating obesity and RA.
|
Report
(3 results)
Research Products
(9 results)
-
-
[Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β.2015
Author(s)
Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
-
Journal Title
EMBO J.
Volume: 34
Issue: 8
Pages: 1042-55
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
