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Study of lipopeptide-specific immunity against AIDS: from monkeys to humans

Research Project

Project/Area Number 26670483
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionKyoto University

Principal Investigator

SUGITA, Masahiko  京都大学, ウイルス研究所, 教授 (80333532)

Co-Investigator(Kenkyū-buntansha) TAKAORI Akifumi  京都大学, 医学研究科, 教授 (20324626)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords細胞・組織 / ウイルス / 免疫学 / 脂質 / エイズ / リポペプチド
Outline of Final Research Achievements

Immune responses directed against viral "peptides" have been studied extensively, which have medical implications, including the development of peptide vaccines. This study focussed on immune responses directed against viral "lipopeptides", and it was elucidated how this new immune pathway was activated. This study has provided an important basis for the near-future identification of such an immune pathway in humans.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2015 Other

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex.2015

    • Author(s)
      Morita D, Yamamoto Y, Mizutani T, Ishikawa T, Suzuki J, Igarashi T, Mori N, Shiina T, Inoko H, Fujita H, Iwai K, Tanaka Y, Mikami B, Sugita M,
    • Journal Title

      Nat Commun.

      Volume: 7 Issue: 1 Pages: 10356-10356

    • DOI

      10.1038/ncomms10356

    • NAID

      120005743661

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 脂質免疫:結核菌やエイズウイルスに対抗する新しい獲得免疫システム2015

    • Author(s)
      杉田昌彦
    • Organizer
      第89回日本感染症学会
    • Place of Presentation
      京都
    • Year and Date
      2015-04-16 – 2015-04-17
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 脂質免疫:結核菌やエイズウイルスに対抗する新しい獲得免疫システム2015

    • Author(s)
      杉田昌彦
    • Organizer
      第89回日本感染症学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Remarks] 京大ウイルス研・杉田研究室

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/SugitaLab.html

    • Related Report
      2015 Annual Research Report 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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