| Project/Area Number |
26670487
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IWASE Tadayuki 東京慈恵会医科大学, 細菌学講座, 講師 (80385294)
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| Research Collaborator |
ITO Kimihiro
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 抗体療法 / 近赤外光 / 感染症 / 黄色ブドウ球菌 / 薬剤耐性菌 / 細菌感染症 / 光線免疫療法 |
|---|
| Outline of Final Research Achievements |
We have developed a method for treating Staphylococcus aureus bacteria by photosensitizer-antibody conjugates against peptidoglycan, the major component of the cell wall of the Gram-positive bacteria, and near-infrared light. Specific binding of photosensitizer-antibody conjugates to the cell wall led to kill the cells specifically upon near-infrared light irradiation in methicillin-susceptible, methicillin-resistant and vancomycin intermediate-susceptible Staphylococcus aureus in vitro. Further studies are warranted for future clinical translation.
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