| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Kawasaki disease generally develops due to microbe infection and is a disease characterized by intense inflammation of the blood vessel in the whole body. Applicants focused on CL-P1 and went the inspection of the hypothesis to bring about sustained blood vessel inflammation in this study. Firstly, they chose CL-P1 as a candidate to bind CRP and evaluated the activation of the complement to on this occasion that an ascent of sudden CRP was generated when some infection and inflammation happened. They showed that CRP trapped by CL-P1 draws C1q, and activates a classical pathway at this place. Furthermore, it was revealed that this reaction activates the alternative pathway. These results suggest the possibility of exercised new complement activation mechanism through CRP.
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