| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Short stature is one of the most common symptoms in pediatric endocrine diseases. We recently found a novel factor responsible for a disease presenting with extreme short stature. In this study, we analyzed the mechanism of this factor related to bone growth. We overexpressed this factor in a cultured cell line and evaluated the cell growth, cell differentiation, and marker proteins. We found that this factor had a repressive effect on chondrocyte growth and differentiation. The repressive effect was increased in the mutants. Furthermore, we have created model animals to investigate the function of this factor in vivo.
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