Molecular biochemical study on febrile convulsion by the exhaustive analysis of the microRNA and protein

• Project/Area Number: 26670497
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Takeuchi Yoshihiro 滋賀医科大学, 医学部, 教授 (80188169)
• Co-Investigator(Kenkyū-buntansha): NARITA Tsutomu 滋賀医科大学, 医学部, 客員助教 (10591836)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 熱性けいれん / MAS解析 / miRNA / 遺伝子解析

Outline of Final Research Achievements

I analyzed peripheral blood samples from 100 patients with febrile convulsion. Tendency of the protein pattern was obtained by MAS analysis. Based on it, I analyze the miRNA pattern of the patient blood. The change of meaningful miRNA has not been yet seen, but continues a study of candidate protein becoming the motive of febrile convulsions.

Research Products

• [Journal Article] Increased apoptosis and hypomyelination in cerebral white matter of macular mutant mouse brain. (2015)
  • Author(s): Takikita S, Takano T, Narita T, Maruo Y.
  • Journal Title: Mol Genet Metab Rep Volume: 4 Pages: 25-29
  • DOI: 10.1016/j.ymgmr.2015.05.005
  • Peer Reviewed
• [Journal Article] Escherichia coli O121:H19 infection identified on microagglutination assay and PCR. (2015)
  • Author(s): Sakai T, Sawai T, Shimizu Y, Morimune T, Okuda Y, Maruo Y, Iyoda S, Takeuchi Y.
  • Journal Title: Pediatr Int. Volume: 57 Issue: 5 Pages: 1001-1003
  • DOI: 10.1111/ped.12699
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neonatal Meckel diverticulum: Obstruction due to a short mesodiverticular band. (2015)
  • Author(s): Kunitsu T, Koshida S, Tanaka K, Nakahara S, Yanagi T, Maruo Y,
  • Journal Title: Pediatr Int. Volume: 57 Issue: 5 Pages: 1007-1009
  • DOI: 10.1111/ped.12694
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A novel large deletion (exons 12, 13) and a missense mutation (p.G46R) in the PAH in a Japanese patient with phenylketonuria. (2015)
  • Author(s): Maruo Y, Suzaki M, Matsui K, Mimura Y, Mori A, Shintaku H, Takeuchi Y.
  • Journal Title: World J Pediatr. Volume: 11 Issue: 2 Pages: 181-184
  • DOI: 10.1007/s12519-015-0020-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Relationship between electrocardiographic signs and shunt volume in atrial septal defect.Pediatr Int (2014)
  • Author(s): Somura J, Nakagawa M, Ukiami M, Sagawa H, Furukawa O, Hoshino S, Fujino H, Takeuchi Y.
  • Journal Title: Pediatr Int Volume: 10 Issue: 4 Pages: 1-4
  • DOI: 10.1111/ped.12569
  • Peer Reviewed
• [Journal Article] Bilirubin Uridine Diphosphate-Glucuronosyltransferase Variation Is a Genetic Basis of Breast Milk Jaundice. (2014)
  • Author(s): Maruo Y, Morioka Y, Fujito H, Nakahara S, Yanagi T, Matsui K, Mori A, Sato H, Tukey RH, Takeuchi Y.
  • Journal Title: J Pediatr Volume: may Issue: 1 Pages: 7-7
  • DOI: 10.1016/j.jpeds.2014.01.060
  • Peer Reviewed