| Project/Area Number |
26670504
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Nagasaki University |
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Principal Investigator |
MORIUCHI Masako 長崎大学, 医歯薬学総合研究科(医学系), 助教 (60322301)
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| Research Collaborator |
MORIUCHI Hiroyuki 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90315234)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ウイルスの干渉作用 / TTウイルス / HIV-1 |
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| Outline of Final Research Achievements |
Enrollment in the Goto Cohort reached only one fifth of total live births. Pilot studies for comprehensive investigation of viral pathogens are in progress, and PCR techniques are ready.Follow-up studies on TTV-infected Vietnamese children are in progress.Effects of TTV coinfection on the prognosis of HIV-infected individuals in Thai HIV Cohort were demonstrated as below:
1)HIV+ individuals were coinfected with TTV genogroup G1,G4 or G5 more frequently than discordant partners.2)There was no correlation between CD4+ cell counts or plasma HIV RNA copy numbers and TTV coinfection (any genogroup) in HIV+ individuals.3)There was significant correlation between plasma TTV DNA copy numbers and HIV copy numbers, and significant inverse correlation between plasma TTV DNA copy numbers and CD4+ counts in antiretroviral therapy-naive HIV+ individuals.4)There was significant correlation between TTV copy numbers and survival rates and between TTV G4 coinfection and survival in HIV+ individuals.
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