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Fabrication of biological arterial graft for congenital heart disease

Research Project

Project/Area Number 26670506
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionYokohama City University

Principal Investigator

YOKOYAMA Utako  横浜市立大学, 医学部, 准教授 (70404994)

Co-Investigator(Kenkyū-buntansha) 郷田 素彦  横浜市立大学, 附属病院, 講師 (30644570)
安田 章沢  横浜市立大学, 附属市民総合医療センター, 助教 (20468169)
Co-Investigator(Renkei-kenkyūsha) MASUDA Munetaka  横浜市立大学, 医学研究科, 教授 (10190365)
MATSUSAKI Michiya  大阪大学, 工学研究科, 助教 (00419467)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords再生医療 / 循環器・高血圧 / 平滑筋 / 人工血管
Outline of Final Research Achievements

We previously demonstrated that a layer by layer method using gelatin and fibronectin enabled to fabricate three-dimensional multi-layered smooth muscle cells. Based on this technique, we aimed to fabricate implantable arterial grafts. We optimized density of cell seeding and incubation time and obtained seven-layered multilayered smooth muscle cells that have 0.05 mm in thickness. The burst pressure was 1874±255 mmHg (718-3138 mmHg). We implanted the sheet into rat abdominal aorta as a patch graft and found graft patency for five month.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (71 results)

All 2017 2016 2015 2014 2012 Other

All Journal Article (21 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 21 results,  Open Access: 19 results,  Acknowledgement Compliant: 7 results) Presentation (42 results) (of which Int'l Joint Research: 3 results,  Invited: 18 results) Book (3 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Arterial graft with elastic layer structure grown from cells.2017

    • Author(s)
      Yokoyama U, Tonooka Y, Koretake R, Akimoto T, Gonda Y, Saito J, Umemura M, Fujita T, Sakuma S, Arai F, Kaneko M, Ishikawa Y.
    • Journal Title

      Sci Rep

      Volume: 1 Issue: 1 Pages: 140-140

    • DOI

      10.1038/s41598-017-00237-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enhanced EP4 Expression in a Pulmonary Artery Aneurysm With Dissection in a Patient With Pulmonary Arterial Hypertension2017

    • Author(s)
      S. Akagi, K. Nakamura, U. Yokoyama, S. Kasahara, T. Sarashina, K. Ejiri, H. Ito
    • Journal Title

      Circulation: Cardiovascular Imaging

      Volume: 10 Issue: 2

    • DOI

      10.1161/circimaging.116.005839

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathology and Molecular Mechanisms of Coarctation of the Aorta and its Association with the Ductus Arteriosus.2017

    • Author(s)
      Yokoyama U, Ichikawa Y, Minamisawa S, Ishikawa Y
    • Journal Title

      J Physiol Sci.

      Volume: 67 Issue: 2 Pages: 259-270

    • DOI

      10.1007/s12576-016-0512-x

    • NAID

      40021113914

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glutamate promotes contraction of the rat ductus arteriosus.2016

    • Author(s)
      Fujita S, Yokoyama U, Ishiwata R, Aoki R, Nagao K, Masukawa D, Umemura M, Fujita T, Iwasaki S, Nishimaki S, Seki K, Ito S, Goshima Y, Asou T, Masuda M, Ishikawa Y. Glutamate promotes contraction of the rat ductus arteriosus.
    • Journal Title

      Circ J

      Volume: 80 Pages: 2388-2396

    • NAID

      130005433144

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Use of Three-dimensional Arterial Models To Predict the In Vivo Behavior of Nanoparticles for Drug Delivery2016

    • Author(s)
      P. Chetprayoon, M. Matsusaki, U. Yokoyama, T. Tejima, Y. Ishikawa, M. Akashi
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 55 Issue: 14 Pages: 4461-4466

    • DOI

      10.1002/anie.201509752

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Epac1 deficiency attenuated vascular smooth muscle cell migration and neointimal formation.2015

    • Author(s)
      Kato Y, Yokoyama U, Yanai C, Ishige R, Kurotaki D, Umemura M, Fujita T, Kubota T, Okumura S, Sata M, Tamura T, Ishikawa Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 35(12) Issue: 12 Pages: 2617-2625

    • DOI

      10.1161/atvbaha.115.306534

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prostaglandin E-mediated molecular mechanisms driving remodeling of the ductus arteriosus.2015

    • Author(s)
      Yokoyama U.
    • Journal Title

      Pediatr Int.

      Volume: 57(5) Issue: 5 Pages: 820-827

    • DOI

      10.1111/ped.12769

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Norepinephrine-induced adrenergic activation strikingly increased the atrial fibrillation duration through β1- and α1-adrenergic receptor-mediated signaling in mice.2015

    • Author(s)
      Suita K, Fujita T, Hasegawa N, Cai W, Jin H, Hidaka Y, Prajapati R, Umemura M, Yokoyama U, Sato M, Okumura S, Ishikawa Y.
    • Journal Title

      PLoS One.

      Volume: 23;10(7) Issue: 7 Pages: e0133664-e0133664

    • DOI

      10.1371/journal.pone.0133664

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coupling of beta1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes.2015

    • Author(s)
      Tsunematsu T, Okumura S, Mototani Y, Ohnuki Y, Jin H, Cai W, SuitaK, Sato I, Umemura M, Yokoyama U, Sato M, Fujita T, and Ishikawa Y.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 458 Issue: 3 Pages: 531-535

    • DOI

      10.1016/j.bbrc.2015.01.149

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oscillation of cAMP and Ca(2+) in cardiac myocytes: a systems biology approach2015

    • Author(s)
      Kamide T, Okumura S, Ghosh S, Shinoda Y, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Fujita T, Yokoyama U, Sato M, Furutani K, Kitano H, Ishikawa Y
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 65(2) Issue: 2 Pages: 195-200

    • DOI

      10.1007/s12576-014-0354-3

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Coupling of beta1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes.2015

    • Author(s)
      TsunematsuT, Okumura S, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Yokoyama U, Sato M, Fujita T, Ishikawa Y.
    • Journal Title

      Biochemical and Biophysical Research Communications (BBRC)

      Volume: -

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microfluidic perfusion culture system for multilayer artery tissue models2014

    • Author(s)
      Yuka Yamagishi, Taisuke Masuda, Michiya Matsusaki, Mitsuru Akashi, Utako Yokoyama, Fumihito Arai
    • Journal Title

      Biomicrofluids

      Volume: 8 Issue: 6 Pages: 064113-064113

    • DOI

      10.1063/1.4903210

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Decreased serum osmolality promotes ductus arteriosus constriction.2014

    • Author(s)
      Aoki R, Yokoyama U, Ichikawa Y, Taguri M, Kumagaya S, Ishiwata R, Yanai C, Fujita S, Umemura M, Fujita T, Okumura S, Sato M, Minamisawa S, Asou T, Masuda M, Iwasaki S, Nishimaki S, Seki K, Yokota S, Ishikawa Y.
    • Journal Title

      Cardiovascular Research

      Volume: 104(2) Issue: 2 Pages: 326-36

    • DOI

      10.1093/cvr/cvu199

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses2014

    • Author(s)
      Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y
    • Journal Title

      J Clin Invest.

      Volume: 124 Issue: 6 Pages: 2785

    • DOI

      10.1172/jci64784

    • URL

      https://localhost/en/publications/36b42ba8-faa2-4af8-8b0f-f7a856c64b49

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protection of cardiomyocytes from the hypoxia-mediated injury by a peptide targeting the activator of G-protein signaling 8.2014

    • Author(s)
      Sato M, Hiraoka M, Suzuki H, Sakima M, Mamun, AA, Yamane Y, Fujita T, Yokoyama U, Okumura S, and Ishikawa Y.
    • Journal Title

      PLoS ONE.

      Volume: 9 Issue: 3 Pages: e91980-e91980

    • DOI

      10.1371/journal.pone.0091980

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperthermia generated with ferucarbotran (Resovis®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells.2014

    • Author(s)
      Sato I, Umemura M, Mitsudo K, Kioi M, Nakashima H, Iwai T Fujita T, Yokoyama U, Okumura S, Feng X, Ito K, Miyajima A, Makino A, Iwai M, Eguchi H, I wai T, and Ishikawa Y.
    • Journal Title

      J. Physiol. Sci.

      Volume: 64 Issue: 3 Pages: 177-183

    • DOI

      10.1007/s12576-014-0309-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Store-operated Ca2 entry (SOCE) Regulates Melanoma Proliferation and Cell Migration.2014

    • Author(s)
      Umemura M, Baljinnyam E, Feske S, De Lorenzo MS, Lai-Hua Xie LH, Feng X, 1, Itoh K, Makino A, Fujita T, Yokoyama U, Iw atsubo M, Chen S, Goydos JS, I shikawa Y, and Iwatsubo K
    • Journal Title

      PLoS ONE.

      Volume: 9 Issue: 2 Pages: e89292-e89292

    • DOI

      10.1371/journal.pone.0089292

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Geranylgeranylacetone protects the heart via caveloae and caveolin-3.2014

    • Author(s)
      Tsutsumi YM, Tsutsumi R, Hirokawa YT, Sakai Y, Hamaguchi E, Ishikawa Y, Yokoyama U, Kasai A, Kambe N, and Tanaka K.
    • Journal Title

      Life Sciences.

      Volume: 101 Issue: 1-2 Pages: 43-48

    • DOI

      10.1016/j.lfs.2014.02.019

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-Dimensional Multilayers of Smooth Muscle Cells as a New Experimental Model for Vascular Elastic Fiber Formation Studies.2014

    • Author(s)
      Ishiwata R, Yokoyama U, Matsusaki M, Yoshiya A, Kadowaki K, Ichikaww Y, Umemura M, Fujita T, Minamisawa S, Shimoda H, Mitsuru Akashi M, and Ishikawa Y.
    • Journal Title

      Atherosclerosis.

      Volume: 233 Issue: 2 Pages: 590-600

    • DOI

      10.1016/j.atherosclerosis.2014.01.045

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prostaglandin E2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling.2014

    • Author(s)
      Yokoyama U, Minamisawa S, Sh ioda A, Ishiwata R, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki II, Nakamura T, and Ishikawa Y
    • Journal Title

      Circulation.

      Volume: 129 Issue: 4 Pages: 487-496

    • DOI

      10.1161/circulationaha.113.004726

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low-dose Thromboxane A2 Receptor Stimulation Promotes Closure of the Rat Ductus Arteriosus with Minimal Adverse Effects2012

    • Author(s)
      Yokota T, Aida T, Ichikawa Y, Fujita T, Yokoyama U, Minamisawa S
    • Journal Title

      Pediatr Res

      Volume: 72 Issue: 4 Pages: 129-36

    • DOI

      10.1371/journal.pone.0094895

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] In vitro fabrication of functional arterial graft by supraphysiological hydrostatic pressurization.2017

    • Author(s)
      Yokoyama U, Saito J, Sakuma S, Arai F, Kaneko M, Ishikawa Y.
    • Organizer
      The 81th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      石川音楽堂(石川県金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] ON-CHIP CELL GYM.2017

    • Author(s)
      Horade M, Kaneko M, Tsai CHD, Ito H, Higashino N, Akai T, Yokoyama U, Ishikawa Y, Sakuma S, Arai F.
    • Organizer
      The 30th IEEE International Conference on Micro Electro Mechanical Systems
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2017-01-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional arterial graft fabricated from pressurized cell-layers.2016

    • Author(s)
      Ishikawa Y, Yokoyama U,Gonda Y, Akimoto T, Sakuma S, Arai F, Kaneko M.
    • Organizer
      European Society of Cardiology
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In-vitro fabrication of scaffold-free arterial grafts by periodic hydrodynamic pressurization.2016

    • Author(s)
      Yokoyama U, Tonooka Y, Koretake R, Akimoto T, Sakuma S, Kaneko M, Ishikawa Y.
    • Organizer
      International and Interdisciplinary Symposium 2016
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2016-07-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The behavior of cells during Cell Exercise.2016

    • Author(s)
      Higashino N, Kaneko M, Yokoyama U, Ishikawa Y
    • Organizer
      ROBOMECH2016
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] The behavior of different cell groups after the partition wall removal.2016

    • Author(s)
      Taniguchi T, Kaneko M, Yokoyama U.
    • Organizer
      ROBOMECH2016
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] The role of Epac1 in the regulatory mechanisms of vascular smooth muscle cell migration and neointimal formation.2016

    • Author(s)
      Kato Y, Yokoyama U, Ishikawa Y.
    • Organizer
      The 93th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市白石区)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Periodic hydrodynamic pressurization promotes layered structure of human arterial smooth muscle cells.2016

    • Author(s)
      Tonooka Y, Yokoyama U, Koretake R, Sakuma S, Kaneko M, Ishikawa Y.
    • Organizer
      The 93th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市白石区)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Fabrication of layered elastic fibers in rat arterial constructs by periodic hydrodynamic pressurization.2016

    • Author(s)
      Gonda Y, Yokoyama U, Koretake R, Sakuma S, Kaneko M, Ishikawa Y.
    • Organizer
      The 93th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市白石区)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 血管平滑筋と細胞外基質制御における新たなホスホリパーゼCとサイクリックAMPの役割The roles of phospholipase C and cyclic AMP in regulation of extracellular matrix in vascular smooth muscle cells.2016

    • Author(s)
      Yokoyama U.
    • Organizer
      The 93th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市白石区)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Inhibition of PGE2-EP4 Signaling as a Potential Future Therapeutic Strategy for Abdominal Aortic Aneurysm.2016

    • Author(s)
      Yokoyama U, Ishiwata R, Ichikawa Y, Yasuda S, Goda M, Suzuki S, Masuda M, Ishikawa Y.
    • Organizer
      The 80th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      仙台国際センター(宮城県仙台市青葉区)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Cell Exerciseによる細胞組織構築法はなぜいいのか2016

    • Author(s)
      横山詩子
    • Organizer
      第28回阪大医療組織工学フォーラム
    • Place of Presentation
      大阪大学(大阪府吹田市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 細胞工学による動脈グラフトの開発2016

    • Author(s)
      横山 詩子, 石川 義弘
    • Organizer
      第19回小児心血管分子医学研究会
    • Place of Presentation
      東京ドームホテル(東京都)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 早産児の動脈管はなぜ閉じないのか2015

    • Author(s)
      横山詩子
    • Organizer
      第28回北海道新生児談話会
    • Place of Presentation
      北海道大学病院(北海道札幌市北区)
    • Year and Date
      2015-11-15
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 動脈管閉鎖の分子機序と新たな薬物療法の可能性2015

    • Author(s)
      横山詩子
    • Organizer
      第24回東海新生児研究会
    • Place of Presentation
      名古屋市立大学病院(愛知県名古屋市瑞穂区)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] プロスタグランディンE受容体―EP4を標的とした大動脈瘤治療の開発2015

    • Author(s)
      横山詩子
    • Organizer
      岡山心臓血管研究会
    • Place of Presentation
      岡山大学病院(岡山県岡山市北区)
    • Year and Date
      2015-09-30
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 平滑筋におけるPGE2-EP4シグナルは腹部大動脈瘤の慢性炎症をつかさどる2015

    • Author(s)
      横山詩子、石渡遼、石川義弘
    • Organizer
      第246回生理学東京談話会
    • Place of Presentation
      東邦大学医学部(東京都大田区)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 未熟児動脈管開存症治療におけるアミノ酸輸液組成の重要性 The effect of amino acids on patent ductus arteriosus in preterm infants2015

    • Author(s)
      横山詩子、藤田秀次郎、青木理加、岩崎志穂、麻生俊英、益田宗孝、関和男、石川義弘
    • Organizer
      第51回日本小児循環器学会総会・学術集会
    • Place of Presentation
      ホテル日航東京(東京都港区)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒト動脈管における内膜肥厚部の遺伝子プロファイリングGene profiling of the intimal thickness in the human ductus arteriosus2015

    • Author(s)
      齋藤純一、横山詩子、市川泰広、益田宗孝、麻生俊英、石川義弘
    • Organizer
      第51回日本小児循環器学会総会・学術集会
    • Place of Presentation
      ホテル日航東京(東京都港区)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 動脈管分化の分子メカニズム2015

    • Author(s)
      横山詩子
    • Organizer
      第51回日本小児循環器学会総会・学術集会
    • Place of Presentation
      ホテル日航東京(東京都港区)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 平滑筋におけるPGE2-EP4シグナルは腹部大動脈瘤の発症を促進する2015

    • Author(s)
      石渡遼、横山詩子、市川泰弘、石川義弘
    • Organizer
      第132回日本薬理学会関東部会
    • Place of Presentation
      明海大学浦安キャンパス(千葉県浦安市)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 動脈管開存症治療における輸液組成の重要性2015

    • Author(s)
      横山詩子
    • Organizer
      神奈川県立こども医療センター第24回心臓血管外科勉強会
    • Place of Presentation
      神奈川県立こども医療センター(神奈川県横浜市南区)
    • Year and Date
      2015-06-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Regulation of collagens in the heart.2015

    • Author(s)
      Yokoyama U.
    • Organizer
      The 79th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      大阪国際会議場(大阪府大阪市北区)
    • Year and Date
      2015-04-25
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Plasminogen activator may promote intimal thickening in the ductus arteriosus.2015

    • Author(s)
      Nicho N, Yokoyama U, Saitoh J, Yanai C, Ichikawa Y, Masuda M, Aso T, Ishikawa Y.
    • Organizer
      The 118th Annual Meeting of the Japan Pediatric Society
    • Place of Presentation
      大阪国際会議場(大阪府大阪市北区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 実験的アプローチによる新たな動脈管開存症治療の開発2015

    • Author(s)
      横山詩子
    • Organizer
      第一回新生児科指導医養成事業による教育セミナー
    • Place of Presentation
      東北大学病院(宮城県仙台市)
    • Year and Date
      2015-03-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Fabrication of tissue-engineered human arterial constructs by cyclic hydrostatic pressure.2015

    • Author(s)
      Tonooka Y, Yokoyama U, Koretake R, Ishiwata R, Sakuma S, Kaneko M, Ishikawa Y.
    • Organizer
      The 92th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] ナノ薄膜技術を用いた高弾性を有する動脈グラフトの作製 Construction of biological elastic vessels by extracellular matrix nanofilm-based cell accumulation technique.2015

    • Author(s)
      Yokoyama U.
    • Organizer
      he 92th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] PGE2-EP4 sigaling promotes vascular intimal thickening via fibulin-1.2015

    • Author(s)
      Yokoyama U, Yanai C, Sato A, Ishikawa Y.
    • Organizer
      The 6th International Conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Secretome-based identification of PGE2-regulated proteins in human abdominal aortic aneurysm.2015

    • Author(s)
      Ishiwata R, Yokoyama U, Arakawa N, Ishikawa Y.
    • Organizer
      The 6th International Conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Research-status Report
  • [Presentation] PGE2-EP4 exerts an anti-fibrotic effect in the heart.2015

    • Author(s)
      Ishiwata R. Yokoyama U, Inoue S, Ichikawa Y, Ishikawa Y.
    • Organizer
      he 6th International Conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Research-status Report
  • [Presentation] PGE2-EP4 sigaling in smooth muscle cell plays a role in chronic inflammation of aortic abdominal aneurysm.2015

    • Author(s)
      Yokoyama U, Ichikawa Y, Ishiwata R, Ishikawa Y.
    • Organizer
      The 6th International Conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] プロスタグランディンE-EP4はfibulin-1を介して生理的・病的血管内膜肥厚の形成に関与する Prostaglandin E2-EP4 is involved in physiological and pathological intimal thickening via fibulin-12014

    • Author(s)
      矢内千春、横山詩子、熊谷駿、手島隆之、佐藤綾美、石川義弘
    • Organizer
      第13回日本心臓血管発生研究会
    • Place of Presentation
      磐梯熱海温泉 ホテル 華の湯(福島県郡山市)
    • Year and Date
      2014-10-17 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Prostaglandin E2-EP4 plays a protective role against cardiac fibrosis.2014

    • Author(s)
      Ishiwata R, Yokoyama U, Inoue S, Ichikawa Y, Ishikawa Y.
    • Organizer
      European Society of Cardiology
    • Place of Presentation
      Barcerona, Spain
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 動脈管は面白い2014

    • Author(s)
      横山詩子
    • Organizer
      第24回心研小児科夏季セミナー
    • Place of Presentation
      東京女子医科大学(東京都新宿区)
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 仕事の多様化について2014

    • Author(s)
      横山詩子
    • Organizer
      横浜市立大学第2回Joinの会
    • Place of Presentation
      横浜市立大学附属市民総合医療センター(神奈川県横浜市)
    • Year and Date
      2014-07-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] プロスタグランディンEによる血管弾性線維の制御メカニズム2014

    • Author(s)
      横山詩子
    • Organizer
      東京農工大学 材料健康科学「Cell to Body Dynamicsセミナー」
    • Place of Presentation
      東京農工大学(東京都小金井市)
    • Year and Date
      2014-07-18
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] グルタミン酸が動脈管閉鎖に及ぼす作用の検討2014

    • Author(s)
      藤田秀次郎、横山詩子、青木理加、岩崎志穂、西巻滋、関和男、横田俊平、石川義弘
    • Organizer
      第50回日本周産期・新生児医学会学術集会
    • Place of Presentation
      シェラトングランデトーキョーベイ(千葉県浦安市)
    • Year and Date
      2014-07-13 – 2014-07-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Early Aggressive Parenteral Nutritionの問題点・PDA2014

    • Author(s)
      横山詩子
    • Organizer
      第50回日本周産期・新生児医学会学術集会
    • Place of Presentation
      シェラトングランデトーキョーベイ(千葉県浦安市)
    • Year and Date
      2014-07-13 – 2014-07-15
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ヒト大動脈瘤組織におけるPGE2-EP4誘導性分泌タンパク質の網羅的解析2014

    • Author(s)
      石渡遼、横山詩子、荒川憲昭、安田章沢、郷田素彦、鈴木伸一、益田宗孝、石川義弘
    • Organizer
      第35回日本循環制御医学会総会
    • Place of Presentation
      福岡大学医学部百年講堂(福岡県福岡市)
    • Year and Date
      2014-07-04 – 2014-07-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Nuclear Factor kappa B Inhibition Promotes Closure of the Rat Ductus Arteriosus.2014

    • Author(s)
      Kajimura I, Yokoyama U, Ishikawa Y, Minamisawa S.
    • Organizer
      Experimental Biology Annual Meetin
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-26 – 2014-04-30
    • Related Report
      2014 Research-status Report
  • [Presentation] cAMP reverses the pro-fibrogenic phenotype of cardiac myofibroblasts.2014

    • Author(s)
      Aroonsakool N, Yokoyama U, Lu D, Patel HH, Insel PA.
    • Organizer
      Experimental Biology Annual Meetin
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-26 – 2014-04-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Prostaglandin E2 receptor EP4 signaling in vascular smooth muscle cells decreases aortic elasticity.2014

    • Author(s)
      Ichikawa Y, Yokoyama U, Ishikawa Y.
    • Organizer
      Experimental Biology Annual Meetin
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-26 – 2014-04-30
    • Related Report
      2014 Research-status Report
  • [Book] Lipid Mediators. Current Reviews and Protocols.2015

    • Author(s)
      Yokoyama U, Ishiwata R, Ishikawa Y.
    • Total Pages
      11
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Book] Etiology and Morphogenesis of Congenital Heart Disease.2015

    • Author(s)
      Yokoyama U*, Minamisawa S, Ishikawa Y.
    • Publisher
      Springer
    • Related Report
      2014 Research-status Report
  • [Book] Nanomedicine and Nanotoxicology.2014

    • Author(s)
      Yokoyama U*, Ishikawa Y.
    • Total Pages
      271
    • Publisher
      Springer
    • Related Report
      2014 Research-status Report
  • [Remarks] 横浜市立大学医学部循環制御医学

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
  • [Remarks] 横浜市立大学医学部循環制御医学

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/index.html

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 三次元組織体及びその製造方法2016

    • Inventor(s)
      明石満、松崎典弥、石川義弘、横山詩子
    • Industrial Property Rights Holder
      明石満、松崎典弥、石川義弘、横山詩子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-04-08
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 三次元組織体及びその製造方法2016

    • Inventor(s)
      明石満、松崎典弥、石川義弘、横山詩子
    • Industrial Property Rights Holder
      明石満、松崎典弥、石川義弘、横山詩子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-04-10
    • Related Report
      2016 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 三次元細胞集合体の作製方法2015

    • Inventor(s)
      横山詩子、石川義弘、金子真、佐久間臣耶、新井史人
    • Industrial Property Rights Holder
      横山詩子、石川義弘、金子真、佐久間臣耶、新井史人
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-09-29
    • Related Report
      2015 Research-status Report
    • Overseas

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Published: 2014-04-04   Modified: 2018-03-22  

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