Models for developmental disorder induced by interaction of maternal stress and fetal factors

• Project/Area Number: 26670512
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Fukuda Atsuo 浜松医科大学, 医学部, 教授 (50254272)
• Co-Investigator(Renkei-kenkyūsha): AKITA Tenpei 浜松医科大学, 医学部, 准教授 (00522202) ; WATANABE Miho 浜松医科大学, 医学部, 助教 (10399321) ; MUTOH Hiroki 浜松医科大学, 医学部, 助教 (60443040) ; HATA Kenichiro 国立成育医療研究センター, 周産期病態研究部, 部長 (60360335) ; UCHIDA Shinichi 東京医科歯科大学, 医歯学総合研究科, 教授 (50262184)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ストレス / 脳発達 / WNK / KCC2 / GABA / コルチコステロン / GAD / 低栄養 / 塩分負荷 / CRH

Outline of Final Research Achievements

We have developed maternal undernutrition model, in which interaction with fetal GAD67 deficiency (GAD67+/GFP) was observed. That was, in contrast to dams, ACTH and CORT increments were significant in heterozygotes. Since WNK3 kinases is an essential element in the signaling cascade regulating Cl－ concentrations after salt intake, we have used a WNK3 KO mice and examined membrane properties. Loss of WNK3 activity significantly reduced neuronal excitability, as evidenced by hyperpolarized resting membrane potential, decreases in input resistance and membrane time constant, and a resulting increase in the threshold current for action potential generation. We examined GAD67+/GFP pups underwent prenatal stress, which showed impaired neurogenesis of parvalbumin-positive GABAergic neurons as well as behavioral abnormality. We found multiple genes related to neurogenesis and/or neural migration were either hyper-methylated or hypo-methylated in GAD67+/GFP underwent prenatal stress.

Research Products

• [Int'l Joint Research] Yale School of Medicine(米国)
• [Int'l Joint Research] マインツ大学(ドイツ)
• [Journal Article] A novel GABA-mediated corticotropin-releasing hormone secretory mechanism in the median eminence. (2016)
  • Author(s): Kakizawa K, Watanabe M, Mutoh H, Okawa Y, Yamashita M, Yanagawa Y, Itoi K, Suda T, Oki Y. and Fukuda A.
  • Journal Title: Science Advances Volume: 2 Issue: 8 Pages: 1-15
  • DOI: 10.1126/sciadv.1501723
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay. (2016)
  • Author(s): Saitsu H, Watanabe M, Akita T, Ohba C, Sugai K, Ong WP, Shiraishi H, Yuasa S, Matsumoto H, Beng KT, Saitoh S, Miyatake S, Nakashima M, Miyake N, Kato M, Fukuda A. and Matsumoto N.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 30072-30072
  • DOI: 10.1038/srep30072
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] De novo KCNB1 mutations in infantile epilepsy inhibit repetitive neuronal firing. (2015)
  • Author(s): Saitsu, H., T. Akita, J. Tohyama, H. Goldberg-Stern, Y. Kobayashi, R. Cohen, M. Kato, C. Ohba, S. Miyatake, Y. Tsurusaki, M. Nakashima, N. Miyake, A. Fukuda, and N. Matsumoto
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 15199-15199
  • DOI: 10.1038/srep15199
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] KCC2-mediated regulation of respiration-related rhythmic activity during postnatal development in mouse medulla oblongata. (2015)
  • Author(s): Okabe A., Shimizu-Okabe C., Arata A., Konishi S., Fukuda A., and Takayama C.
  • Journal Title: Brain Res. Volume: 1601 Pages: 31-39
  • DOI: 10.1016/j.brainres.2015.01.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development and regulation of chloride homeostasis in the central nervous system. (2015)
  • Author(s): Watanabe, M., *Fukuda, A.
  • Journal Title: Frontiers in Cellular Neuroscience Volume: 9 Pages: 1-14
  • DOI: 10.3389/fncel.2015.00371
  • Peer Reviewed / Open Access
• [Journal Article] Control of cortical neuronal migration by glutamate and GABA. (2015)
  • Author(s): Luhmann, H.J., Kilb, W. and Fukuda, A.
  • Journal Title: Frontiers in Cellular Neuroscience Volume: 9 Pages: 4-4
  • DOI: 10.3389/fncel.2015.00004
  • Peer Reviewed / Open Access
• [Journal Article] Activation of glycine receptors modulates spontaneous epileptiform activity in the immature rat hippocampus. (2014)
  • Author(s): Chen, R., Okabe, A., Sun, H., Sharopov, S., Hanganu-Opatz, I.L., Kolbaev, S.N., Fukuda, A., Luhmann, H.J.and Kilb, W.
  • Journal Title: The Journal of Physiology Volume: 592 Issue: 10 Pages: 2153-2168
  • DOI: 10.1113/jphysiol.2014.271700
  • Peer Reviewed / Open Access
• [Journal Article] Roles of taurine-mediated tonic GABAA receptor activation in radial migration of neurons in the fetal mouse cerebral cortex. (2014)
  • Author(s): Furukawa T, Yamada J, Akita T, Matsushima Y, Yanagawa Y, Fukuda A
  • Journal Title: Frontiers in Cellular Neuroscience Volume: 8 Pages: 88-88
  • DOI: 10.3389/fncel.2014.00088
  • Peer Reviewed / Open Access
• [Journal Article] Selective loss of parvalbumin-positive GABAergic interneurons in the cerebral cortex of maternally stressed Gad1-heterozygous mouse offspring. (2014)
  • Author(s): Uchida, T., Furukawa, T., Iwata, S., Yanagawa, Y. and *Fukuda, A.
  • Journal Title: Translational Psychiatry Volume: 4 Issue: 3 Pages: e371-e371
  • DOI: 10.1038/tp.2014.13
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Functional deficiency of MHC class I enhances LTP and abolishes LTD in the nucleus accumbens of mice. (2014)
  • Author(s): Edamura, M., Murakami, G., Meng, H., Itakura, M., Shigemoto R., Fukuda, A. and Nakahara, D.
  • Journal Title: PLoS ONE Volume: 9 Issue: 9 Pages: e107099-e107099
  • DOI: 10.1371/journal.pone.0107099
  • Peer Reviewed / Open Access
• [Journal Article] The role of GABA in the regulation of GnRH neurons. (2014)
  • Author(s): Watanabe, M., Fukuda, A. and Nabekura, J.
  • Journal Title: Frontiers in Neuroscience Volume: 8 Pages: 1-9
  • DOI: 10.3389/fnins.2014.00387
  • Peer Reviewed / Open Access
• [Journal Article] マルチモーダルGABAによる発振と同期 (2014)
  • Author(s): 福田敦夫
  • Journal Title: Clinical Neuroscience Volume: 32 Pages: 751-756
• [Presentation] The role of excitatory action of GABA in the regulation of reproduction. (2017)
  • Author(s): Watanabe M, Nabekura J and Fukuda A.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（静岡県・浜松市）
  • Year and Date: 2017-03-30
• [Presentation] A novel role of GABA in the release of CRH in the hypothalamic-pituitary pathway. (2017)
  • Author(s): Kakizawa K. and Fukuda A.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（静岡県・浜松市）
  • Year and Date: 2017-03-30
• [Presentation] Taurine depletion reduces postsynaptic GABAA receptors in layer 2/3 pyramidal neurons of the somatosensory cortex. (2017)
  • Author(s): Hosoi Y, Akita T, Watanabe M, Mutoh H, Miyajima H and Fukuda A.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（静岡県・浜松市）
  • Year and Date: 2017-03-29
• [Presentation] Mild functional impairment of neuronal K+-Cl－ cotransporter KCC2 by biallelic mutations causes migrating focal seizures and severe developmental delay. (2017)
  • Author(s): Akita T, Saitsu H, Watanabe M, Matsumoto N and Fukuda A.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（静岡県・浜松市）
  • Year and Date: 2017-03-29
• [Presentation] Excitatory roles of WNK3 in layer V pyramidal neurons in the prefrontal cortex. (2017)
  • Author(s): Sinha Adya S, Hosoi Y, Sohara E, Mutoh H, Akita T, Uchida S and Fukuda A.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（静岡県・浜松市）
  • Year and Date: 2017-03-29
• [Presentation] Maternal stress causes loss of parvalbumin neurons and alterations of extracellular glycans in the mPFC of GAD67-GFP knock-in mouse. (2017)
  • Author(s): Wang T, Sinha adya S, Yanagawa Y, Hata K and Fukuda A.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（静岡県・浜松市）
  • Year and Date: 2017-03-28
• [Presentation] 胎仔脳内タウリンがニューロンの細胞内Ca2＋濃度と膜電位の振動に与える影響とその生理的意義. (2017)
  • Author(s): 福田敦夫, 古川智範, 熊田達郎.
  • Organizer: 第3回国際タウリン研究会日本部会
  • Place of Presentation: つくばイノベーションセンター（茨城県・つくば市）
  • Year and Date: 2017-02-11
• [Presentation] Excitatory GABAergic input from the arcuate nucleus promotes CRH release from axon terminals with NKCC1-driven high [Cl-]i as a novel secretory mechanism at median eminence. (2016)
  • Author(s): Kakizawa K, Watanabe M, Mutoh H, Okawa Y, Yamashita M, Yanagawa Y, Itoi K, Suda T, Oki Y and Fukuda A.
  • Organizer: 2016 International Symposium on Neurodegenerative Diseases
  • Place of Presentation: Xi'an Nanyang Hotel （Xi’an, China）
  • Year and Date: 2016-11-11
  • Int'l Joint Research
• [Presentation] 乳児焦点移動性部分発作はSLC12A5遺伝子の両アレル変異によるカリウム-クロライド共役担体(KCC2)機能の低下により引き起こされる. (2016)
  • Author(s): 渡部美穂, 秋田天平, 才津浩智, 松本直通, 福田敦夫.
  • Organizer: 第63回中部日本生理学会
  • Place of Presentation: 生理学研究所（愛知県・岡崎市）
  • Year and Date: 2016-11-04
• [Presentation] Excitatory roles of WNK3 in layer V pyramidal neurons in the prefrontal cortex. (2016)
  • Author(s): Sinha Adya S, Hosoi Y, Sohara E, Mutoh H, Akita T, Uchida S, Fukuda A.
  • Organizer: 第63回中部日本生理学会
  • Place of Presentation: 生理学研究所（愛知県・岡崎市）
  • Year and Date: 2016-11-04
• [Presentation] タウリン欠乏は生後の大脳皮質感覚野錐体細胞への抑制性シナプス入力を減少させる. (2016)
  • Author(s): 細井泰志, 秋田天平, 武藤弘樹, 渡部美穂, 伊藤崇志, 福田敦夫.
  • Organizer: 第63回中部日本生理学会
  • Place of Presentation: 生理学研究所（愛知県・岡崎市）
  • Year and Date: 2016-11-04
• [Presentation] 視床下部ストレス応答におけるGABA作用の多様性とそのメカニズム. (2016)
  • Author(s): 福田敦夫.
  • Organizer: 第43回日本神経内分泌学会学術集会
  • Place of Presentation: アクトシティ浜松（静岡県・浜松市）
  • Year and Date: 2016-10-14
  • Invited
• [Presentation] Dynamics of inhibitory synaptic function underlying epileptogenesis. (2016)
  • Author(s): 福田敦夫.
  • Organizer: 第50回日本てんかん学会学術集会
  • Place of Presentation: グランシップ（静岡県・静岡市）
  • Year and Date: 2016-10-08
• [Presentation] 脳発達障害モデルにおけるGABA作用と母体-胎仔間シグナル. (2016)
  • Author(s): 福田敦夫.
  • Organizer: 福井大学医学系研究科大学院セミナー
  • Place of Presentation: 福井大学（福井県・吉田郡）
  • Year and Date: 2016-09-28
  • Invited
• [Presentation] マルチモーダルなGABAの作用. (2016)
  • Author(s): 福田敦夫.
  • Organizer: 第96回北海道医学大会生理系分科会・日本生理学会北海道地方会
  • Place of Presentation: 札幌医科大学（北海道・札幌市）
  • Year and Date: 2016-09-10
  • Invited
• [Presentation] てんかん原性におけるCl－ホメオダイナミクス仮説：理論から症例まで. (2016)
  • Author(s): 福田敦夫.
  • Organizer: 札幌医科大学医学部神経科学講座特別セミナー
  • Place of Presentation: 札幌医科大学（北海道・札幌市）
  • Year and Date: 2016-09-09
  • Invited
• [Presentation] De novo mutations in Kv2.1 channels found in infantile epileptic patients inhibit repetitive neuronal firing. (2016)
  • Author(s): Akita T, Saitsu H, Matsumoto N and Fukuda A.
  • Organizer: The 13th Korea-Japan Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscle Sciences
  • Place of Presentation: 佐賀大学（佐賀県・佐賀市）
  • Year and Date: 2016-08-26
  • Int'l Joint Research
• [Presentation] Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay. (2016)
  • Author(s): Watanabe M, Akita T, Saitsu H, Matsumoto N and Fukuda A.
  • Organizer: The 13th Korea-Japan Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscle Sciences
  • Place of Presentation: 佐賀大学（佐賀県・佐賀市）
  • Year and Date: 2016-08-26
  • Int'l Joint Research
• [Presentation] A novel excitatory GABAergic input from the arcuate nucleus to the median eminence involved in CRH release. (2016)
  • Author(s): Fukuda A, Kakizawa K, Watanabe M, Mutoh H, Okawa Y, Yamashita M, Yanagawa Y, Itoi K, Suda T and Oki Y.
  • Organizer: The 13th Korea-Japan Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscle Sciences
  • Place of Presentation: 佐賀大学（佐賀県・佐賀市）
  • Year and Date: 2016-08-24
  • Int'l Joint Research
• [Presentation] 母仔相関に関与する液性シグナルとGABA－Cl-ホメオスタシスに基づく脳発達障害モデル. (2016)
  • Author(s): 福田敦夫.
  • Organizer: 第5回日本DOHaD研究会学術集会
  • Place of Presentation: 国立成育医療研究センター（東京都・世田谷区）
  • Year and Date: 2016-07-23
  • Int'l Joint Research
• [Presentation] Partial loss of neuronal KCC2 function by biallelic SLC12A5 mutations causes migrating focal seizures and developmental delay. (2016)
  • Author(s): Watanabe M, Akita T, Saitsu H, Matsumoto N and Fukuda A.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-07-22
• [Presentation] Excitatory roles of WNK3 in layer V pyramidal neurons in the prefrontal cortex. (2016)
  • Author(s): Sinha Adya S, Hosoi Y, Sohara E, Mutoh H, Akita T, Uchida S, Fukuda A.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-07-22
• [Presentation] An immunocytochemical study for the local glutamatergic system in rat trigeminal ganglion. (2016)
  • Author(s): Hayasaki, H., Fukuda, A., Sohma, Y.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-07-22
• [Presentation] Prenatal stress causes loss of GABAergic interneurons and perineuronal nets in the cerebral cortex of GAD67-GFP knock-in mouse offspring. (2016)
  • Author(s): Fukuda A, Wang T, Yanagawa Y, Kawai T and Hata K.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-07-21
• [Presentation] Taurine depletion reduces postnatal inhibitory synaptic inputs into layer 2/3 pyramidal neurons in the somatosensory cortex. (2016)
  • Author(s): Hosoi Y, Akita T, Mutoh H, Ito T, Miyajima H and Fukuda A.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-07-21
• [Presentation] The excitatory GABA action at the median eminence maintains the steady-state release of corticotropin-releasing hormone. (2016)
  • Author(s): Fukuda A.
  • Organizer: 10th FENS Forum of Neuroscience
  • Place of Presentation: Bella Center (Copenhagen,Denmark)
  • Year and Date: 2016-07-02
• [Presentation] Aberrant oscillation property of Perkinje cells is caused by decreased tonic inhibitionin granule in granule cells in mice model of Angelman syndrome. (2016)
  • Author(s): Egawa, K. and Fukuda, A.
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター（北海道・札幌市）
  • Year and Date: 2016-03-23
• [Presentation] De novo Kv2.1 mutants causing infantile generalized seizures and psychomotor developmental delay inhibit repetitive neuronal firing. (2016)
  • Author(s): Akita, T., Saitsu, H., Matsumoto, N. and Fukuda, A.
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター（北海道・札幌市）
  • Year and Date: 2016-03-23
• [Presentation] 発生期マウス大脳皮質においてGABAA受容体と母体由来タウリンは神経前駆細胞の時系列的性質変化を制御する. (2016)
  • Author(s): 栃谷史郎, 古川智範, 伊藤崇志, 松島芳隆, 小島俊男, 松崎秀夫, 福田敦夫.
  • Organizer: 第2回国際タウリン研究会日本部会
  • Place of Presentation: アオッサ福井（福井県福井市）
  • Year and Date: 2016-03-05
• [Presentation] Taurine is involved in the temporal regulation of the properties of neural progenitors in the mouse developing cortex. (2015)
  • Author(s): 栃谷史郎, 古川智範, 伊藤崇志, 小島俊男, 松崎秀夫, 福田敦夫.
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド（兵庫県・神戸市）
  • Year and Date: 2015-12-02
• [Presentation] CRH放出機構における新規GABA作用の発見. (2015)
  • Author(s): 福田敦夫, 柿沢圭亮, 渡部美穂, 大川雄太, 大石敏弘, 山下美保, 柳川右千夫, 沖隆.
  • Organizer: 第42回日本脳科学会
  • Place of Presentation: ANAホリデイ・イン リゾート宮崎（宮崎県・宮崎市）
  • Year and Date: 2015-11-12
• [Presentation] 出生前ストレス曝露による生後大脳皮質におけるGABA細胞とペリニューラルネットの減少. (2015)
  • Author(s): 福田敦夫.
  • Organizer: 第13回糖鎖科学コンソーシアムシンポジウム
  • Place of Presentation: ウインクあいち（愛知県名古屋市）
  • Year and Date: 2015-10-20
  • Invited
• [Presentation] Dual effects of serotoninergic inputs on the local circuits regulating the corticotropin-releasing factor neurons in the paraventricular nucleus of the hypothalamus: an electrophysiological study using the CRF-VenusΔNeo mouse. (2015)
  • Author(s): Sato, T., Sugiya, T., Fuse, T., Uchida, K., Sugimoto, N., Abe, M., Yamazaki, M., Fukuda, A., Sakimura, K. and Itoi, K.
  • Organizer: Society for Neuroscience 2015
  • Place of Presentation: Chicago(USA)
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] CRHニューロン制御におけるGABAの新たな役割についての検討. (2015)
  • Author(s): 柿沢圭亮，渡部美穂，大川雄太，大石敏弘，山下美保，柳川右千夫，沖 隆，福田敦夫.
  • Organizer: 第42回日本神経内分泌学会・第23回日本行動神経内分泌研究会・合同学術集会
  • Place of Presentation: 仙台市戦災復興記念館（宮城県・仙台市）
  • Year and Date: 2015-09-19
• [Presentation] Taurine concentration and distribution in brain of frontaltemporal lobar degeneration patients. (2015)
  • Author(s): Matsushita, S., Masaki, N, Kondo, T., Takei, S., Akatsu, H., Akita, T., Sugiyama, E., Fukuda, A., Yao, I. and Setou, M.
  • Organizer: 第40回日本医用マススペクトル学会年会
  • Place of Presentation: アクトシティ浜松（静岡県・浜松市）
  • Year and Date: 2015-09-17
• [Presentation] Visualization of the glutamate release in the plexiform layers of the mouse retina. (2015)
  • Author(s): Ohkuma, M., Horio, K., Kaneda, M., Yoshida, S., Fukuda, A. and Miyachi, E.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県・神戸市）
  • Year and Date: 2015-07-30
• [Presentation] Persistent reduction of MHC class I in dopamine neurons contributes to robust cocaine-seeking behavior. (2015)
  • Author(s): Murakami, G., Fukuda, A., Iwashita, T. and Nakahara, D.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県・神戸市）
  • Year and Date: 2015-07-29
• [Presentation] A novel role of GABA in the release of CRH in the hypothalamo-pituitary pathway. (2015)
  • Author(s): Kakizawa, K., Watanabe, M., Yanagawa, Y., Oki, Y. and Fukuda, A.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] Prenatal stress-induced selective deterioration of neurogenesis of parvalbuminpositive GABAergic neurons. (2015)
  • Author(s): Fukuda, A.
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県・神戸市）
  • Year and Date: 2015-03-23
• [Presentation] Functional regulation of neuronal K+-Cl−cotransporter KCC2. (2015)
  • Author(s): Watanabe, M., Iwata, S., Furukawa, T., Kumada, T., Uchida, T., Hirose, S. and Fukuda, A.
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県・神戸市）
  • Year and Date: 2015-03-23
• [Presentation] Maternal taurine modulate fetal brain development by affecting Cl-homeostasis and GABAA receptors. (2015)
  • Author(s): Fukuda, A.
  • Organizer: The 12th Korea-Japan Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscle Sciences
  • Place of Presentation: Yongin(Korea)
  • Year and Date: 2015-01-23
• [Presentation] 母体由来タウリンが胎仔脳の形成とその特異性に与える影響 (2014)
  • Author(s): 古川智範, 福田敦夫.
  • Organizer: 第41回日本脳科学会
  • Place of Presentation: 福井県県民ホール（福井県・福井市）
  • Year and Date: 2014-11-22
• [Presentation] Alterlations in extracellular sugar chain in prenatally stressed mouse brain. (2014)
  • Author(s): Fukuda, A. and Wang, T.
  • Organizer: SFG & JSCR 2014 Joint Annual Meeting
  • Place of Presentation: Honolulu (USA)
  • Year and Date: 2014-11-16
• [Presentation] GAD67-GFP knockinマウスを用いた CRH ニューロン制御における GABA の役割についての検討 (2014)
  • Author(s): 柿沢圭亮, 渡部美穂, 柳川右千夫, 沖隆, 福田敦夫.
  • Organizer: 第61回中部日本生理学会
  • Place of Presentation: 名古屋市立大学（愛知県・名古屋市）
  • Year and Date: 2014-11-07
• [Presentation] 発達期のマルチモーダルなGABA受容体作用から麻酔薬毒性を考察する (2014)
  • Author(s): 福田敦夫
  • Organizer: 第34回日本臨牀麻酔学会
  • Place of Presentation: グランドプリンスホテル新高輪国際館パミール（東京都・港区）
  • Year and Date: 2014-11-03
• [Presentation] GAD67-GFP ノックインマウスを用いた CRH ニューロン制御における GABA の役割についての検討. (2014)
  • Author(s): 柿沢圭亮, 渡部美穂, 大川雄太, 大石敏弘, 山下美保, 柳川右千夫, 沖隆, 福田敦夫.
  • Organizer: 第41回日本神経内分泌学会学術集会
  • Place of Presentation: 都道府県会館（東京都・千代田区）
  • Year and Date: 2014-11-01
• [Presentation] Maternally-derived ambient taurine plays a pivotal role in radial migration in the embryonic mouse neocortex by tonically activating GABAA receptors. (2014)
  • Author(s): Fukuda, A., Furukawa, T., Yamada, J., Akita, T., Matsushima, Y., Yanagawa, Y.
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2014-09-12
• [Presentation] Maternal taurine modulates immature aspect of GABA actions involved in epileptogenesis. (2014)
  • Author(s): Fukuda, A.
  • Organizer: The 16th Annual Meeting of Infantile Seizure Society (ISS): International Symposium on Epileptic Syndromes of Early Infancy and Childhood (ISES)
  • Place of Presentation: Cappadocia, (Turkey)
  • Year and Date: 2014-06-23
  • Invited
• [Book] 脳とタウリン, 読んで効くタウリンのはなし (2016)
  • Author(s): 福田敦夫
  • Total Pages: 194
  • Publisher: 成山堂書店
• [Book] GABAとその受容体, 臨床てんかん学 (2015)
  • Author(s): 福田敦夫
  • Total Pages: 671
  • Publisher: 医学書院
• [Remarks] 浜松医科大学医学部神経生理学講座ホームページ
  • URL: http://www.hama-med.ac.jp/uni_education_igakubu_igaku_seiri1.html