| Project/Area Number |
26670517
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hokkaido University |
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Principal Investigator |
ABE Riichiro 北海道大学, 医学(系)研究科(研究院), 准教授 (60344511)
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| Co-Investigator(Renkei-kenkyūsha) |
SUTO Asuka 北海道大学, 大学院医学研究科
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | ミトコンドリア / 角化 / 皮膚 |
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| Outline of Final Research Achievements |
Mitochondria have many vital functions, including ATP production, calcium buffering and cell death. In keratinization, it is not well known the relationship of mitochondria and keratin. We investigated Mfn and showed mitochondria move along with keratin via Mfn in keratinocytes. In addition, abnormality of keratin induced defect of mitochondria function.
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