Development of therapy for skin diseases by utilizing regulatory B cells

Research Project

Project/Area Number	26670521
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Dermatology
Research Institution	University of Tsukuba
Principal Investigator	Fujimoto Manabu 筑波大学, 医学医療系, 教授 (90272591)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	免疫 / 皮膚免疫 / B細胞 / 膠原病 / 悪性腫瘍
Outline of Final Research Achievements	Microarray analysis suggested that PTEN is involved in the signal transduction of regulatory B cell development. Conditional kick-out mice that has no PTEB expression specifically in B cells were generated. In this mouse, a novel regulatory B cell subset was identified in B-1 cell population. This subset has potent suppressing capability in various immune responses, and thus is considered as a potential target in treating autoimmune diseases and cancers. Additionally, new cell surface markers for regulatory B cells are identified.