| Project/Area Number |
26670524
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Sakabe Jun-ichi 浜松医科大学, 医学部, 特任助教 (30631494)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 免疫学 / 発現制御 / 細胞・組織 / 蛋白 |
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| Outline of Final Research Achievements |
The significance of stratum corneum (SC) barrier has been strengthened in the pathogenesis of atopic dermatitis (AD). Many other SC constituents and proteases are also known to be involved in the barrier. Here, we sought to identify and quantify wide-ranging proteins by proteome analysis of SC samples obtained by using a noninvasive tape stripping technique. We categorized the representative substances into 5 groups: inflammation-associated substances, SC barrier constituents, SC barrier-related enzymes, antimicrobial peptides, and sweat-associated substances. Many substances were changed in their amounts in AD-SC compared with healthy control (HC) SC. For example, the amounts of GCDFP15 were significantly lower in AD than HC. The sweat samples from AD patients also had lower levels of GCDFP15 concentration. GCDFP15 in SC is a potential marker for dysregulated sweating in AD.
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