| Project/Area Number |
26670525
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
Masashi Kato 名古屋大学, 医学系研究科, 教授 (10281073)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
武田 湖州恵 中部大学, 生命健康科学部, 准教授 (80345884)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAJIMA Ichiro 名古屋大学, 医学系研究科, 講師 (80469022)
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | メラノーマ / バイオマーカー / 分子標的療法 / 動物モデル / BRAF変異 / RET / RET-マウス / DTX3L / 免疫療法 / LSF / p21 / 国際情報交換 / モデル動物 |
|---|
| Outline of Final Research Achievements |
We previous developed RET-transgenic mice (RET-mice), in which development of hyperpigmented skin and benign melanocytic tumors at about 100% and development of melanoma at about 65%. In this study, we first selected molecules after performing microarray analysis using benign tumor and melanoma developed in RET-mouse. We then performed functional analysis for these three molecules. The molecules are involved in the regulation for anchorage- independent growth, invasion and metastasis. Thus, we have not only proposed plural candidate molecules that are available as a biomarker of melanoma but also provided basic data for developing a molecular target therapy that suppress melanoma proliferation, infiltration and metastasis.
|
