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Development of novel therapeutic strategy for skin diseases by utilizing anti-inflammatory activity of circulating mesenchymal stem cells

Research Project

Project/Area Number 26670531
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionOsaka University

Principal Investigator

TAMAI Katsuto  大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (20236730)

Project Period (FY) 2014-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
KeywordsHMGB1 / 間葉系幹細胞 / 接触性皮膚炎 / 皮膚炎 / 抗炎症 / 再生誘導
Outline of Final Research Achievements

In this study, we aimed to develop a novel anti-inflammatory therapy for allergic contact dermatitis by utilizing anti-inflammatory activity of bone marrow mesenchymal stem cells (MSCs), which were mobilized from bone marrow into the circulation by high mobility group box 1 (HMGB1). Systemic administration of HMGB1 to contact hypersensitivity model mouse showed significant anti-inflammatory effect by inducing accumulation of bone marrow-derived MSCs in the skin lesion. We further elucidated that CXCR4/SDF-1 axis was involved in the accumulation of circulating MSCs into the lesion, and that inoculated HMGB1 induced expression of CXCR4, a receptor for chemokine SDF-1, on the MSC surface. These results indicate that systemically administered HMGB1 suppresses inflammatory reactions not only by inducing mobilization of MSCs from bone marrow into circulation, but also by accelerating accumulation of the circulating MSCs into the inflammatory/injured tissues by enhancing CXCR4/SDF-1 axis.

Report

(2 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (6 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Invited: 4 results)

  • [Journal Article] Transplanted bone marrow-derived circulating PDGFRα+ cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft.2015

    • Author(s)
      Iinuma S, Aikawa E, Tamai K, Fujita R, Kikuchi Y, Chino T, Kikuta J, McGrath JA, Uitto J, Ishii M, Iizuka H, Kaneda Y.
    • Journal Title

      Journal of Immunology

      Volume: 194(4) Issue: 4 Pages: 1996-2003

    • DOI

      10.4049/jimmunol.1400914

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Endogenous mesenchymal stromal cells in bone marrow are required to preserve muscle function in mdx mice.2015

    • Author(s)
      Fujita R, Tamai K, Aikawa E, Nimura K, Ishino S, Kikuchi Y, Kaneda Y.
    • Journal Title

      Stem Cells

      Volume: 33(3) Issue: 3 Pages: 962-975

    • DOI

      10.1002/stem.1900

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 骨髄間葉系幹細胞を利用した表皮水疱症治療2015

    • Author(s)
      玉井克人
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 表皮水疱症update:基礎と臨床、教育講演1:皮膚難病への挑戦~厚労省皮膚難病研究班からの報告を含めて2014

    • Author(s)
      玉井克人
    • Organizer
      第113回日本皮膚科学会総会・学術大会
    • Place of Presentation
      京都
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 表皮水疱症の患者さんから学んだ皮膚とこころの再生メカニズム:皮膚は地球を救う.2014

    • Author(s)
      玉井克人
    • Organizer
      日本創傷・オストミー・失禁管理学会
    • Place of Presentation
      大宮
    • Year and Date
      2014-05-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Update on EB Clinical Trial: (Mini-Symposium) on Epidermolysis Bullosa2014

    • Author(s)
      Katsuto Tamai
    • Organizer
      International EB meeting
    • Place of Presentation
      Albuquergue, USA
    • Year and Date
      2014-05-07
    • Related Report
      2014 Annual Research Report
    • Invited

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Published: 2014-04-04   Modified: 2016-06-03  

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