The algorithm to determine the causative gene of the familial tumor represented by elastofibroma dorsi
Project/Area Number |
26670532
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Dermatology
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Research Institution | University of the Ryukyus |
Principal Investigator |
UEZATO Hiroshi 琉球大学, 医学(系)研究科(研究院), 教授 (10137721)
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Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Kenzo 琉球大学, 大学院医学研究科, 准教授 (80291425)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 背部弾性線維腫 / 家族性腫瘍 / 琉球諸島 / 軟部腫瘍 / 良性腫瘍 / ヘテロ接合性の喪失 / ハプロ接合性の喪失 / 遺伝性腫瘍 / 母斑性腫瘍 / 次世代シークエンサ- / 沖縄人ゲノム / 多様性の消失 / 次世代シークエンサ |
Outline of Final Research Achievements |
We aimed to identify the anti-oncogene, which should be the causative gene of familial cases of elastofibroma dorsi. All gene variations were selected by the subtraction of genome mutations between the tumor tissues and the peripheral-blood genome of several elastofibroma dorsi cases. The target causative gene should have mutated in both peripheral blood genome and tumor cells in the different way. However, the genome variations of the people living in the Aguni Island, where elastofibroma dorsi occurs frequently, were very similar among cases, and lacking in diversity. By the procedure, in which we choose the genome variation of the usual existence coefficient of 1% or less, it became clear by making the whole Japanese's average genome as a standard genome, it could not narrow down easily. We are now looking for the putative causative gene by PCR amplification from previous many pathological paraffin fixed blocks.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Conspicuous Bilateral Eyelids Swelling Appeared in a Patient with Subcutaneous Panniculitis-like T-cell Lymphoma2015
Author(s)
林 健太郎, 宮城 拓也, 園崎 哲, 山口 さやか, 山本 雄一, 高橋 健造, 西 由希子, 仲地 佐和子, 友寄 毅昭, 益崎 裕章, 上里 博
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Journal Title
Nishi Nihon Hifuka
Volume: 77
Issue: 5
Pages: 487-491
DOI
NAID
ISSN
0386-9784, 1880-4047
Related Report
Peer Reviewed / Open Access
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[Journal Article] 先天性Bednar腫瘍の1例2015
Author(s)
林 健太郎, 仲村 郁心, 眞鳥 繁隆, 粟澤 剛, 山本 雄一, 苅谷 嘉之, 高橋 健造, 上里 博
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Journal Title
日本小児皮膚科学会雑誌
Volume: 34
Pages: 131-135
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ayadaulin, a novel RGD peptide with dual antihemostatic activities from the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis2015
Author(s)
Kato, H., Gomez, E.L., Fujita, M., Ishimaru, Y., Uezato, H., Mimori, T., Iwata, H., Hashiguchi, Y.
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Journal Title
Biochimie
Volume: 112
Pages: 49-56
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Increasing trends in cervical cancer mortality among young Japanese women below the age of 50 years: an analysis using the Kanagawa population-based Cancer Registry, 1975-2012.2015
Author(s)
Motoki Y, Mizushima S, Taguri M, Takahashi K, Asano R, Kato H, Asai-Sato M, Katayama K, Okamoto N, Hirahara F, Miyagi E.
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Journal Title
Cancer Epidemiol
Volume: 39
Issue: 5
Pages: 700-706
DOI
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Peer Reviewed / Open Access
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[Journal Article] Novel compound heterozygous DNA ligase IV mutations in an adolescent with a slowly-progressing radiosensitive-severe combined immunodeficiency.2015
Author(s)
Tamura S, Higuchi K, Tamaki M, Inoue C, Awazawa R, Mitsuki N, Nakazawa Y, Mishima H, Takahashi K, Kondo O, Imai K, Morio T, Ohara O, Ogi T, Furukawa F, Inoue M, Yoshiura K, Kanazawa N.
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Journal Title
Clin Immunol
Volume: 160
Pages: 255-260
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genetic divergence in populations of Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis in Ecuador and Peru2014
Author(s)
Kato, H., Caceres, A.G., Gomez, E.A.L., Mimori, T., Uezato, H., Hashiguchi, Y.
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Journal Title
Acta Tropica
Volume: 141
Pages: 79-87
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A Case of Giant Subcutaneous Dermoid Cyst of the Right Shoulder2014
Author(s)
片野 あずさ, 内海 大介, 大平 葵, 粕谷 百合子, 苅谷 嘉之, 崎枝 薫, 眞鳥 繁隆, 平良 清人, 高橋 健造, 上里 博
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Journal Title
Nishi Nihon Hifuka
Volume: 76
Issue: 5
Pages: 469-472
DOI
NAID
ISSN
0386-9784, 1880-4047
Related Report
Peer Reviewed / Open Access
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