| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Mouse hair follicle bulge stem cells acquire the stemness during development, but its mechanisms remain largely unknown. We test the significance of tendon-like function of bulge stem cells in their stemness acquisition. We performed the in-depth transcriptome analysis of adult hair follicle bulge stem cells and demonstrated that bulge stem cells highly express many tendon-related genes including Scleraxis (Scx), an essential gene for tendon morphogenesis. The expression of Scx is induced in the bulge stem cells when they start expressing stem cell marker genes. But the deletion of Scx did not show any significant phenotype in the bulge stem cells.
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