| Project/Area Number |
26670534
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Yoshida Takayuki 北海道大学, 医学(系)研究科(研究院), 助教 (60374229)
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Masahiko 北海道大学, 医学研究科, 教授 (70210945)
OHMURA yu 北海道大学, 医学研究科, 助教 (80597659)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 扁桃体 / セロトニン / カンナビノイド / ドーパミン / ストレス / モノアミン / 海馬 / 腹側被蓋野 |
|---|
| Outline of Final Research Achievements |
Endocannabinoids were produced by activation of postsynaptic serotonin (5-HT) receptor as well as decreased presynaptic 5-HT release by the activation of the CB1 receptor in the amygdala. We demonstrated that it was caused by calcium- and neuronal activity-dependent manner. In addition, it was revealed that excitability of the pyramidal neuron in the adult amygdala was enhanced by aversive stress at juvenile periods and by activations of 5-HTergic receptors. We also revealed that the 5-HT7 receptor of CA3 pyramidal cell in the ventral hippocampus participated in recalls of the fear memory through the activation of Ih current.
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