Relationship between sensory processing and sociality in young children with autism spectrum disorder.

• Project/Area Number: 26670537
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kanazawa University
• Principal Investigator: Kikuchi Mitsuru 金沢大学, 子どものこころの発達研究センター, 教授 (00377384)
• Co-Investigator(Kenkyū-buntansha): Hayashi Norio 群馬県立県民健康科学大学, 講師 (50648459)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 自閉症 / 脳内ネットワーク / 聴覚誘発反応 / 脳磁図 / 幼児 / 自閉症スペクトラム / 聴覚情報処理 / MEG

Outline of Final Research Achievements

Main aim of the present study is to investigate the relationship between sensory processing and sociality in young children with autism spectrum disorder (ASD).The auditory evoked field (AEF), recorded by magnetoencephalography, and the synchronization of these processes between right and left hemispheres was recently suggested to reflect various cognitive abilities in children.Using Omega complexity analysis, we investigated the global coordination of AEFs in 3 to 8-year-old typically developing (TD) children and children with ASD in 50-ms time-windows. Children with ASD displayed significantly higher Omega complexities compared with TD children in the time-window of 0 - 50 ms, suggesting lower whole brain synchronization in the early stage of the auditory processing. These results suggest lower right-left hemispheric synchronization in children with ASD compared with TD children. We could not find significant relationships between Omega complexities and symptoms (e.g., sociality).

Research Products

• [Int'l Joint Research] University of Montreal(カナダ)
• [Int'l Joint Research] University of Washington(米国)
• [Journal Article] Atypical Bilateral Brain Synchronization in the Early Stage of Human Voice Auditory Processing in Young Children with Autism. (2016)
  • Author(s): Kurita T, Kikuchi M, Yoshimura Y, Hiraishi H, Hasegawa C, Takahashi T, Hirosawa T, Furutani N, Higashida H, Ikeda T, Mutou K, Asada M, Minabe Y.
  • Journal Title: PLoS One Volume: 13 Issue: 4 Pages: 0153077-0153077
  • DOI: 10.1371/journal.pone.0153077
  • Peer Reviewed / Open Access
• [Journal Article] Enhanced brain signal variability in children with autism spectrum disorder during early childhood. (2016)
  • Author(s): Takahashi T, Yoshimura Y, Hiraishi H, Hasegawa C, Munesue T, Higashida H, Minabe Y, Kikuchi M.
  • Journal Title: Hum Brain Mapp. Volume: 37（3） Issue: 3 Pages: 1038-1050
  • DOI: 10.1002/hbm.23089
  • Peer Reviewed / Open Access
• [Journal Article] Magnetoencephalography in the study of children with autism spectrum disorder. (2016)
  • Author(s): Kikuchi M, Yoshimura Y, Mutou K, Minabe Y.
  • Journal Title: Psychiatry Clin Neurosci. Volume: 70 Issue: 2 Pages: 74-88
  • DOI: 10.1111/pcn.12338
  • Peer Reviewed
• [Journal Article] Changes in autistic trait indicators in parents and their children with ASD: A preliminary longitudinal study. (2015)
  • Author(s): Hasegawa C, Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Takesaki N, Higashida H, Oi M, Minabe Y, Asada M.
  • Journal Title: Psychiatry Res. Volume: 30 Issue: 1 Pages: 956-957
  • DOI: 10.1016/j.pscychresns.2015.04.003
  • Peer Reviewed
• [Journal Article] Changes in EEG complexity with electroconvulsive therapy in a patient with autism spectrum disorders: a multiscale entropy approach. (2015)
  • Author(s): Okazaki R, Takahashi T*, Ueno K, Takahashi, Ishitobi M, Kikuchi M, Higashima M, Wada Y.
  • Journal Title: Front Hum Neurosci Volume: ９ Pages: 17-17
  • DOI: 10.3389/fnhum.2015.00106
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Attentional control and interpretation of facial expression after oxytocin administration to typically developed male adults. (2015)
  • Author(s): Hirosawa T, Kikuchi M, Okumura E, Yoshimura Y, Hiraishi H, Munesue T, Takesaki N, Furutani N, Ono Y, Higashida H, Minabe Y
  • Journal Title: PLoS One Volume: 6 Issue: 2 Pages: e0116918-e0116918
  • DOI: 10.1371/journal.pone.0116918
  • Peer Reviewed / Open Access
• [Journal Article] Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders. (2015)
  • Author(s): Hasegawa C, Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Nakatani H, Higashida H, Asada M, Oi M, Minabe Y.
  • Journal Title: Psychiatry Clin Neurosci Volume: 69 Issue: 3 Pages: 136-144
  • DOI: 10.1111/pcn.12210
  • Peer Reviewed
• [Journal Article] Reduced long-range functional connectivity in young children with autism spectrum disorder. (2015)
  • Author(s): Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Hashimoto T, Tsubokawa T, Takahashi T, Suzuki M, Higashida H, Minabe Y.
  • Journal Title: Soc Cogn Affect Neurosci. Volume: 10 Issue: 2 Pages: 248-254
  • DOI: 10.1093/scan/nsu049
  • Peer Reviewed / Open Access
• [Journal Article] A longitudinal study of auditory evoked field and language development in young children (2014)
  • Author(s): Yoshimura Yuko, Kikuchi Mitsuru, Ueno Sanae, Shitamichi Kiyomi, Remijn Gerard, Hiraishi Hirotoshi, Hasegawa Chiaki, Furutani Naoki, Oi Manabu, Munesue Toshio, Tsubokawa Tunehisa, Higashida Haruhiro, Minabe Yoshio
  • Journal Title: NeuroImage Volume: 1;101 Pages: 440-447
  • DOI: 10.1016/j.neuroimage.2014.07.034
  • Peer Reviewed / Open Access
• [Presentation] Atypical brain auditory processing in young children with autism spectrum disorder. (2015)
  • Author(s): 菊知 充 三邉 義雄
  • Organizer: 第58回 神経化学会
  • Place of Presentation: 大宮ソニックシティ（さいたま市
  • Year and Date: 2015-09-12
• [Presentation] 幼児の長所を見える化し、弱点克服をモニターする (2015)
  • Author(s): 菊知 充
  • Organizer: 第5回CiNetシンポジウム
  • Place of Presentation: 東京国際フォーラムホール（東京）
  • Year and Date: 2015-06-17
• [Presentation] 自閉症スペクトラム障害児のMEG研究 (2015)
  • Author(s): 菊知 充
  • Organizer: 第57回日本小児神経学会学術集会
  • Place of Presentation: 帝国ホテル大阪（大阪）
  • Year and Date: 2015-05-29
• [Presentation] Brain connectivity during a high-level visual perceptual task in young ASD children: a MEG investigation (2015)
  • Author(s): Mitsuru Kikuchi, Laurent Mottron, Natsumi Takesaki, Tetsuya Takahashi, Tetsu Hirosawa, Yuko Yoshimura, Naoki Furutani, Hirotoshi Hiraishi, Chiaki Hasegawa, Sachiko Kitagawa, Yoshio Minabe
  • Organizer: The International Meeting for Autism Research.
  • Place of Presentation: Salt Lake City, Utah, USA.
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] Mental rotation: a high-level perceptual strength of young ASD children. (2015)
  • Author(s): Yuko Yoshimura, Laurent Mottron, Natsumi Takesaki,Tetsuya Takahashi, Tetsu Hirosawa, Naoki Furutani,Hirotoshi Hiraishi, Chiaki Hasegawa, Sachiko Kitagawa, Yoshio Minabe, Mitsuru Kikuchi
  • Organizer: The International Meeting for Autism Research.
  • Place of Presentation: Salt Lake City, Utah, USA.
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] 幼児脳の個性の「見える化」への取り組み (2014)
  • Author(s): 菊知 充
  • Organizer: 第3回金沢大学子どものこころサミット
  • Place of Presentation: 赤羽ホール（金沢）
  • Year and Date: 2014-11-29
• [Presentation] 自閉症スペクトラム障害の認知特性と脳機能の特徴 (2014)
  • Author(s): 菊知 充
  • Organizer: 第14回、「精神疾患と認知機能研究会」
  • Place of Presentation: 海運クラブ（東京）
  • Year and Date: 2014-11-08
• [Presentation] Neuroimaging for brain development in young children (2014)
  • Author(s): 菊知 充
  • Organizer: 第4回 賀戸久先生記念研究会
  • Place of Presentation: TOKYU REIT 虎ノ門ビル（東京）
  • Year and Date: 2014-11-07
  • Invited
• [Presentation] 広汎性発達障害の早期診断のための診断システム開発 (2014)
  • Author(s): 菊知 充
  • Organizer: 第45回公益財団法人アステラス病態代謝研究会
  • Place of Presentation: 日本工業倶楽部（東京）
  • Year and Date: 2014-10-18
• [Remarks] バンビプラン
  • URL: http://bambiplan.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学子どものこころの発達研究センター
  • URL: http://kodomokokoro.w3.kanazawa-u.ac.jp/
• [Remarks] 連合小児発達学研究科 金沢校
  • URL: http://rengou.w3.kanazawa-u.ac.jp/