• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a detection method for circadian rhythm sleep disorders based on clock gene expression

Research Project

Project/Area Number 26670543
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionYamaguchi University

Principal Investigator

Akashi Makoto  山口大学, 時間学研究所, 教授 (30398119)

Co-Investigator(Renkei-kenkyūsha) TOKUDA Isao  立命館大学, 理工学部, 教授 (00261389)
HIRANO Hitoshi  山口大学, 保健管理センター, 教授 (70228807)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords概日時計 / 時計遺伝子 / 睡眠 / 睡眠障害 / 概日リズム
Outline of Final Research Achievements

Although the determination of human circadian phase requires the phase estimation based on clock gene expression rhythms, simple and effective methods in clinical settings remain undeveloped. In this study, we have optimized experimental procedures in a phase estimation method using hair follicles that we previously reported, and succeeded in dramatically increasing the measurement sensitivity for clock gene expression levels. Moreover, using this improved method, we have tried to detect "masked circadian rhythm sleep disorders", which are difficult to detect with traditional approaches such as sleep diary and actogram. Consequently, simple and rapid detection of masked circadian rhythm sleep disorders has been realized by calculating and comparing time intervals between socially-enforced time schedules (in particular waking time on work days) and estimated circadian phases in clock gene expression rhythms using hair follicles.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Invited: 2 results) Book (6 results)

  • [Journal Article] Estimation methods for human circadian phase using peripheral tissues2016

    • Author(s)
      Matsumura. R., Node. K., Akashi. M.
    • Journal Title

      Hypertension Research

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] なぜ体内時計は大切なのか2015

    • Author(s)
      明石 真
    • Organizer
      電気・情報関連学会中国支部連合大会
    • Place of Presentation
      山口大学(山口県宇部市)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 食と体内時計2015

    • Author(s)
      明石 真
    • Organizer
      日本糖尿病学会
    • Place of Presentation
      下関市民会館(山口県下関市)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] New Diet Therapy2016

    • Author(s)
      明石 真
    • Total Pages
      6
    • Publisher
      日本臨床栄養協会
    • Related Report
      2015 Annual Research Report
  • [Book] いま小児科医に必要な実践臨床小児睡眠医学2015

    • Author(s)
      明石 真
    • Total Pages
      9
    • Publisher
      診断と治療社
    • Related Report
      2015 Annual Research Report
  • [Book] Diabetes Journal2015

    • Author(s)
      明石 真
    • Total Pages
      9
    • Publisher
      協和企画
    • Related Report
      2015 Annual Research Report
  • [Book] 医学のあゆみ2015

    • Author(s)
      明石 真、野出孝一
    • Total Pages
      6
    • Publisher
      医歯薬出版
    • Related Report
      2015 Annual Research Report
  • [Book] 時間学研究2015

    • Author(s)
      野村直樹、橋元淳一郎、明石 真
    • Total Pages
      14
    • Publisher
      日本時間学会
    • Related Report
      2015 Annual Research Report
  • [Book] THE LUNG perspectives2015

    • Author(s)
      明石 真
    • Total Pages
      8
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi