| Project/Area Number |
26670552
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
KIYONO Yasushi 福井大学, 高エネルギー医学研究センター, 教授 (50305603)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Tetsuya 福井大学, 高エネルギー医学研究センター, 教授 (40397287)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 放射性医薬品 / テロメラーゼ活性 / 放射性銅 / PET |
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| Outline of Final Research Achievements |
Cancer cells are immortal because the activity of telomerase is increased. The imaging of telomerase activity would provide the useful information about the therapeutic effect and prediction of cancer treatment. Therefore, we designed the imaging probe for measuring telomerase activity and synthesized [64Cu]PcTS and then investigated this as a telomerase activity imaging probe. In cell uptake study, the uptake of [64Cu]PcTS was increased with time. This result suggests that [64Cu]PcTS has a potential as an imaging probe for measuring telomerase activity.
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