An attempt to improve the possibilities of controlling local tumors through taking it into account to increase the sensitivity of oxic quiescent tumor cells
Project/Area Number |
26670556
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Kyoto University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
田野 恵三 京都大学, 原子炉実験所, 准教授 (00183468)
宮武 伸一 大阪医科大学, 医学部, 特別職務担当教員(教授) (90209916)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 休止期腫瘍細胞 / 酸素化休止期腫瘍細胞 / 低酸素領域 / 腫瘍内微小環境 / 中性子捕捉療法 / サリドマイド / p53 status / メトフォルミン / 放射線治療生物学 / 低酸素腫瘍細胞 / HIF-1 alpha / ビグアナイド系抗糖尿病薬剤 / 急性低酸素領域 / 腫瘍血管正常化 |
Outline of Final Research Achievements |
Thalidomide released the acute hypoxia during tumor vascular normalization and suppressed distant lung metastasis from the local tumor. Analysis of the relation with oxygen concentration during culturing using p53 wild-type and mutant tumor cells showed that the boron-10 uptake was significantly reduced in hypoxic culture compared with under normal oxygen and also markedly reduced in wild type tumor cells than in p53 mutant cells especially when BPA was used compared with BSH. After establishment of HIF-1α deficient tumor cells, deficiency of HIF-1α was shown to enhance the sensitivity to metformin in culture under glucose depletion, markedly enhance the sensitivity to metformin in hypoxic culture, and remarkably improve the radio-sensitivity of solid tumor through combination with metformin.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma2017
Author(s)
Futamura G, Kawabata S, Nonoguchi N, Hiramatsu R, Toho T, Tanaka H, Masunaga SI, Hattori Y, Kirihata M, Ono K, Kuroiwa T, Miyatake SI
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Journal Title
Radiat Oncol.
Volume: 12
Issue: 1
Pages: 26-26
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effect of oxygen pressure during incubation with a 10B-carrier on 10B uptake capacity of cultured p53 wild-type and mutated tumor cells: dependency on p53 status of tumor cells and types of 10B-carriers2016
Author(s)
Masunaga S, Tatebe H, Nishimura Y, Tano K, Sanada Y, Moriwaki T, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Maruhashi A and Ono K
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Journal Title
International Journal of Radiation Biology
Volume: 92
Issue: 4
Pages: 187-194
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparison of the pharmacokinetics between L-BPA and L-FBPA using the same administration dose and protocol: a validation study for the theranostic approach using [18F]-L-FBPA positron emission tomography in boron neutron capture therapy2016
Author(s)
Tsubasa Watanabe, Yoshihide Hattori, Youichiro Ohta, Miki Ishimura, Yosuke Nakagawa, Yu Sanada, Hiroki Tanaka, Satoshi Fukutani, Shin-ichiro Masunaga, Masahiro Hiraoka, Koji Ono, Minoru Suzuki, Mitsunori Kirihata
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Journal Title
BMC Cancer
Volume: 16
Issue: 1
Pages: 859-868
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] DNA damage induced by boron neutron capture therapy is partially repaired by DNA ligase IV2016
Author(s)
Kondo N, Sakurai Y, Hirota Y, Tanaka H, Watanabe T, Nakagawa Y, Narabayashi M, Kinashi Y, Miyatake S, Hasegawa M, Suzuki M, Masunaga S, Ohnishi T, Ono K.
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Journal Title
Radiat Environ Biophys
Volume: 55(1)
Issue: 1
Pages: 89-94
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Proteomic analysis of cellular response induced by boron neutron capture reaction in human squamous cell carcinoma SAS cells2015
Author(s)
Sato A., Itoh T., Imamichi S., Kikuhara S., Fujimori H., Hirai T., Saito S., Sakurai Y., Tanaka H., Nakamura H., Suzuki M., Murakami Y., Baiseitov D., Berikkhanova K., Zhumadilov Z., Imahori Y., Itami J., Ono K., Masunaga S., Masutani M.
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Journal Title
Applied Radiation and Isotopes
Volume: 106
Pages: 113-219
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Localized radiation necrosis model in mouse brain using proton ion beams.2015
Author(s)
Kondo N, Sakurai Y, Takata T, Takai N, Nakagawa Y, Tanaka H, Watanabe T, Kume K, Toho T, Miyatake S, Suzuki M, Masunaga S, Ono K.
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Journal Title
Applied Radiation and Isotopes
Volume: 106
Pages: 242-246
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Improvement of depth dose distribution using multiple-field irradiation in boron neutron capture therapy2015
Author(s)
N. Fujimoto, H. Tanaka, Y. Sakurai, T. Takata, N. Kondo, M. Narabayashi, Y. Nakagawa, T. Watanabe, Y. Kinashi, S. Masunaga, A. Maruhashi, K. Ono, M. Suzuki,
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Journal Title
Applied Radiation and Isotopes
Volume: 106
Pages: 134-138
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The effect of oxygen pressure during incubation with a 10B-carrier on 10B uptake capacity of cultured p53 wild-type and mutated tumor cells - Dependency on the p53 status of tumor cells and the type of 10B-carrier.2015
Author(s)
Masunaga S, Tatebe H, Nishimura Y, Tano K, Sanada Y, Moriwaki T, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Maruhashi A and Ono K.
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Journal Title
Oncology Reports
Volume: -
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Significance of Fractionated Administration of Thalidomide Combined With γ-Ray Irradiation in Terms of Local Tumor Response and Lung Metastasis.2014
Author(s)
Masunaga S, Sanada Y, Moriwaki T, Tano K, Sakurai Y, Tnaka H, SuzukiM, Kondo N, Narabayashi M, Watanabe T, Nakagawa Y, Maruhashi A, Ono K.
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Journal Title
World Journal of Oncology
Volume: 5
Pages: 155-165
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Synthesis and in vitro evaluation of thiododecaborated α, α‑cycloalkylamino acids for the treatment of malignant brain tumors by boron neutron capture therapy.2014
Author(s)
Hattori Y, Kusaka S, Mukumoto M, Ishimura M, Ohta Y, Takenaka H, Uehara K, Asano T, Suzuki M, Masunaga S, Ono K, Tanimori S, Kirihata M.
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Journal Title
Amino Acid
Volume: 46
Issue: 12
Pages: 2715-2720
DOI
Related Report
Peer Reviewed
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[Presentation] Effect of oxygen pressure during incubation with a 10B-carrier on 10B uptake capacity of cultured p53 wild-type and mutated tumor cells with reference to dependency on p53 status of tumor cells and types of 10B-carriers.2016
Author(s)
Masunaga S, Tatebe H, Nishimura Y, Tano K, Sanada Y, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Watanabe T, Takata T, Fujimoto N, Maruhashi A, Ono K.
Organizer
the 17th International Congress on Neutron Capture Therapy
Place of Presentation
Columbia, Missouri, USA
Year and Date
2016-10-02
Related Report
Int'l Joint Research
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[Presentation] Significance of fractionated administrations of thalidomide combined with gamma-ray irradiation from the viewpoint of local tumor response and lung metastasis.2016
Author(s)
Masunaga S, Sanada Y, Moriwaki T, Tano K, Sakurai Y, Tanaka H, Suzuki M,, Narabayashi M, Watanabe T, and Ono K.
Organizer
the 2016 Annual Meeting of the American Roentgen Ray Society
Place of Presentation
Washington DC, USA
Year and Date
2016-04-17
Related Report
Int'l Joint Research
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[Presentation] The effect of fractionated administration of thalidomide at γ-ray irradiation on tumor response and lung metastasis.2016
Author(s)
S. Masunaga, K. Tano, Y. Sanada, Y. Sakurai, H. Tanaka, M. Suzuki, N. Kondo, M. Narabayashi, T. Watanabe, Y. Nakagawa, A. Maruhashi, and K. Ono.
Organizer
International Conference on Translational Research in Radiation Oncology -- Physics for Health in Europe 2016
Place of Presentation
International Center for Conference in Geneva, Geneva, Switzerland
Year and Date
2016-02-15
Related Report
Int'l Joint Research
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[Presentation] ホウ素‐中性子捕捉療法に用いる次世代型ホウ素薬剤の開発2016
Author(s)
服部 能英,石村 美紀,大田 洋一,竹中 宏誌,上原 幸樹, 浅野 智之, 鈴木 実, 増永慎一郎, 小野 公二,切畑 光統
Organizer
第18回癌治療増感研究シンポジウム、変貌する放射線治療法~物理・化学・生物学増感法のリミックスと免疫学のコラボレーション~
Place of Presentation
奈良県文化会館(奈良県、奈良市)
Year and Date
2016-02-05
Related Report
Invited
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[Presentation] The effect of oxygen pressure during incubation with a 10B-carrier on 10B uptake capacity of cultured p53 wild-type and mutated tumor cells.2015
Author(s)
Masunaga S, Tatebe H, Nishimura Y, Tano K, Sanada Y, Moriwaki T, Sakurai Y, TanakaH, Suzuki M, Maruhashi A,Ono K.
Organizer
The 15th International Congress of Radiation Research (ICRR)
Place of Presentation
Kyoto International Conference Center, (京都府、京都市)
Year and Date
2015-05-25
Related Report
Int'l Joint Research
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[Presentation] The Usefulness of Heavy-ion Beam to the Radioresistance and the Metastatic Potential Enhanced by Cyclic Hypoxia Condition.2015
Author(s)
Matsumoto Y, Yamashita K, Li H, Kaneko Y, Sun L, Moritake T, Uzawa A, Hirayama R, Ando K, Masunaga S, Shirai T, Furusawa Y, Sakurai H.
Organizer
The 15th International Congress of Radiation Research (ICRR)
Place of Presentation
Kyoto International Conference Center, (京都府、京都市)
Year and Date
2015-05-25
Related Report
Int'l Joint Research
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[Presentation] The dependency of CBE factors on the concentration of administered neutron capture agents in BNCT.2014
Author(s)
Masunaga S, Sakurai Y, Tanaka H, Tano K, Suzuki M, Kondo N, Narabayashi M, Watanabe T, Nakagawa Y, Maruhashi A and Ono K.
Organizer
The 2nd KURRI International Workshop on BNCT - Basic Science and Technology for BNCT -
Place of Presentation
Kyodai Rakuyu Kaikan, Kyoto, Japan
Year and Date
2014-12-09 – 2014-12-10
Related Report
Invited
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[Presentation] Significance of Administering Bevacizumab Combined with Boron Neutron Capture Therapy in terms of Local Tumor Control and Lung Metastatic Potential.2014
Author(s)
Masunaga S, Sakurai Y, Tano K, Tanaka H, Suzuki M, Kondo N, NarabayashiM, Watanabe T, Nakagawa Y, Maruhashi A, Ono K.
Organizer
the 56th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO)
Place of Presentation
Moscone center, San Francisco, USA
Year and Date
2014-09-14 – 2014-09-17
Related Report
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[Presentation] Effect of bevacizumab combined with boron neutron capture therapy on local tumor response and lung metastasis.2014
Author(s)
Masunaga S, Sakurai Y, Tanaka H, Tano K, Suzuki M, Kondo N, Narabayashi M, Watanabe T, Maruhashi A, Ono K.
Organizer
the 6th Asian Congress of Hyperthermic Oncology (ACHO) & the 31st Japanese Congress of Thermal Medivine (JCTM)
Place of Presentation
AOSSA, Fukui, Japan
Year and Date
2014-09-05 – 2014-09-06
Related Report
Invited
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[Presentation] Significance of Combined Treatment with Bevacizumab in Boron Neutron Capture Therapy in Terms of Local Tumor Response and Lung Metastasis.2014
Author(s)
Masunaga S, Sakurai Y, Tano,K Tanaka H, Suzuki M, Kondo N, Narabayashi M, Watanabe T, Nakagawa Y, Maruhashi A and Ono K.
Organizer
the 16th International Congress on Neutron Capture Therapy
Place of Presentation
Poerssitalo, Helsinki, Finland
Year and Date
2014-06-14 – 2014-06-19
Related Report
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[Presentation] Design and Synthesis of Tumor Seeking closo-Dodecaborate-Containing Amino Acids as Boron Carrier for BNCT.2014
Author(s)
Hattori Y, Ishimura M, Mukumoto M, Ohta Y, Takenaka H, Uehara K, Asano T, Suzuki M, Masunaga S, Ono K and Kirihata M.
Organizer
the 16th International Congress on Neutron Capture Therapy
Place of Presentation
Poerssitalo, Helsinki, Finland
Year and Date
2014-06-14 – 2014-06-19
Related Report
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