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Histological analysis of the radiosensitizing effects of hydrogen peroxide through the resolution of endogenous peroxidase

Research Project

Project/Area Number 26670561
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionShimane University

Principal Investigator

Inomata Taisuke  島根大学, 医学部, 教授 (90176462)

Co-Investigator(Kenkyū-buntansha) 稗田 洋子  島根大学, 医学部, 助教授 (00181058)
玉置 幸久  島根大学, 医学部, 講師 (40457099)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordshydrogen peroxide / radiation therapy / radiosensitizer / 過酸化水素 / 放射線増感 / 放射線治療 / 放射線増感剤 / 抗酸化酵素 / アポトーシス
Outline of Final Research Achievements

The anti-tumor effects of radiation therapy in combination with hydrogen peroxide were analyzed.
For superficial and exposed tumors, hydrogen peroxide soaked gauze was put on the tumor’s surface each time just before irradiation. For non-dermatological tumors, hydrogen peroxide containing sodium hyaluronate was injected homogeneously into the tumor twice a week after delivering 20Gy. The total dose ranged from 18Gy to 66Gy.
The anti-tumor effects of hydrogen peroxide were excellent and 90% of the patients achieved complete or good response. The radiosensitizing effect was predominant especially in the radio resistant tumors that were irradiated without hydrogen peroxide. The histological findings observed in the tumor was mainly composed of sever necrosis.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2017

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 過酸化水素による放射線増感効果が得られた進行再発乳癌の1例2017

    • Author(s)
      植 敦士、稗田洋子、玉置幸久、猪俣泰典、百留美樹、板倉正幸
    • Organizer
      第24回島根乳腺疾患研究会
    • Place of Presentation
      浜田医療センター
    • Year and Date
      2017-03-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 島根大学における過酸化水素による放射線増感効果を期待した放射線治療の取り組み2017

    • Author(s)
      猪俣泰典、玉置幸久、稗田洋子、植 敦士
    • Organizer
      第19回山陰放射線腫瘍学研究会
    • Place of Presentation
      米子コンベンションセンター
    • Year and Date
      2017-02-18
    • Related Report
      2016 Research-status Report
  • [Presentation] Efficacy of Enzyme-targeting Chemo-Radiosensitization Therapy for Locally-advanced /recurrent Tumors and Post-operative Residual Tumors2017

    • Author(s)
      T. Inomata, A. Ue, Y. Hieda, Y. Tamaki, Y. Ogawa
    • Organizer
      American Society for Radiation Oncology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2019-03-29  

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