| Project/Area Number |
26670562
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Okayama University |
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Principal Investigator |
UEDA Masashi 岡山大学, 医歯(薬)学総合研究科, 准教授 (40381967)
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| Co-Investigator(Kenkyū-buntansha) |
HIGAKI Yusuke 岡山大学, 医歯(薬)学総合研究科, 助教 (50598133)
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| Research Collaborator |
MATSUURA Yuki
SANO Kohei
SAJI Hideo
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 分子イメージング / ニコチン性アセチルコリン受容体 / アルツハイマー病 |
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| Outline of Final Research Achievements |
The present study aimed to investigate the feasibility of imaging central nicotinic acetylcholine receptors (nAChRs) as an objective and quantitative biomarker of cognitive function. It was demonstrated that a decreases in nAChR expression was correlated with cognitive decline in a mouse model of Alzheimer’s disease. The decrease in nAChR expression was noninvasively detected with single-photon emission computed tomography using 123I-5IA, an imaging probe that targets nAChRs. These findings indicate that nAChR could be a useful imaging biomarker of cognitive function.
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