Feasibility evaluation of central nicotinic acetylcholine receptors as an imaging biomarker of cognitive function
| Project/Area Number |
26670562
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
UEDA Masashi 岡山大学, 医歯(薬)学総合研究科, 准教授 (40381967)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIGAKI Yusuke 岡山大学, 医歯(薬)学総合研究科, 助教 (50598133)
|
|---|
| Research Collaborator |
MATSUURA Yuki
SANO Kohei
SAJI Hideo
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 分子イメージング / ニコチン性アセチルコリン受容体 / アルツハイマー病 |
|---|
| Outline of Final Research Achievements |
The present study aimed to investigate the feasibility of imaging central nicotinic acetylcholine receptors (nAChRs) as an objective and quantitative biomarker of cognitive function. It was demonstrated that a decreases in nAChR expression was correlated with cognitive decline in a mouse model of Alzheimer’s disease. The decrease in nAChR expression was noninvasively detected with single-photon emission computed tomography using 123I-5IA, an imaging probe that targets nAChRs. These findings indicate that nAChR could be a useful imaging biomarker of cognitive function.
|
Report
(3 results)
Research Products
(5 results)
