Thermosensitive ferromagnetic particles with absorption base which release anticancer agent by applying magnetic field.

• Project/Area Number: 26670574
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Akita University
• Principal Investigator: SAITO Hajime 秋田大学, 医学(系)研究科(研究院), 准教授 (20323149)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 磁性体 / がん / 温熱療法 / 悪性腫瘍

Outline of Final Research Achievements

We have developed a method of magnetically induced hyperthermia using thermosensitive ferromagnetic particles (FMPs) with low Curie temperature (Tc) enough to mediate automatic temperature control. In this work, we evaluated the effect of our original hyperthermia system combined with the delivery of anticancer drug from absorption base in vitro. The result was that melting point (43℃，44℃，45℃) correspond to the concentration of agar was confirmed, and PTX or DTX was released significantly in appropriate temperature. The proliferation of cultured cancer cells was inhibited by PTX, DTX respectively combined with our original hyperthermia system. Further investigation, including in vivo experiment, was needed to making them ideal candidates for cancer thermo-chemotherapy.