| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
For the prevention of the chronic rejection after renal transplantation, the polypharmacy of the immunosuppressive drug for a long term is provided. However, the long-term dosage of the immunosuppressive drugs results in the immunodeficiency.
It is known that chronic inflammation induced by the alloantigen-specific memory T cells is one of the causes of the chronic rejection. Here, we show that DNAM-1 plays an important role in generation of alloantigen-specific memory of immunity by using DNAM-1-deficient mice. Moreover, we observed that fibrosis of the kidney after renal transplantation was much milder in DNAM-1-deficient mice compared with those in wild-type mice. These results suggest that DNAM-1 might be a good molecular target for prevention of the chronic rejection after the renal transplantation.
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