| Project/Area Number |
26670576
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ABE Yusuke 東京大学, 医学(系)研究科(研究院), 准教授 (90193010)
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| Research Collaborator |
HARA Shintaro 東京大学, 大学院医学系研究科, 特任研究員
WATANABE Shingo 鈴鹿医療科学大学, 医用工学部, 学部生
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 人工肺 / シリコーン中空糸 / コンプライアンス効果 / シリコン中空糸 |
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| Outline of Final Research Achievements |
An extracorporeal membrane oxygenation has been used to rescue severe respiratory failure and/or heart failure patients. However, it cannot be used for a long time limited by the life of artificial lung. Therefore, it is an urgent matter to develop an artificial lung for long-term use. In this study, to develop an artificial lung that can be used for one year, a pulsatile pumping method utilizing compliance effect of silicone hollow fiber was proposed and examined with newly developed inner perfusion-type artificial lung using silicone hollow fiber. In pulsatile pumping method, gas or blood were pumped to have pulsation. The results showed that the oxygenation efficiency did not increase with pulsatile pumping of gas but had increasing tendency with pulsatile pumping of blood.
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