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Basic study to develop an artificial lung for long-term use utilizing compliance effect of silicone hollow fiber

Research Project

Project/Area Number 26670576
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionThe University of Tokyo

Principal Investigator

ABE Yusuke  東京大学, 医学(系)研究科(研究院), 准教授 (90193010)

Research Collaborator HARA Shintaro  東京大学, 大学院医学系研究科, 特任研究員
WATANABE Shingo  鈴鹿医療科学大学, 医用工学部, 学部生
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords人工肺 / シリコーン中空糸 / コンプライアンス効果 / シリコン中空糸
Outline of Final Research Achievements

An extracorporeal membrane oxygenation has been used to rescue severe respiratory failure and/or heart failure patients. However, it cannot be used for a long time limited by the life of artificial lung. Therefore, it is an urgent matter to develop an artificial lung for long-term use. In this study, to develop an artificial lung that can be used for one year, a pulsatile pumping method utilizing compliance effect of silicone hollow fiber was proposed and examined with newly developed inner perfusion-type artificial lung using silicone hollow fiber. In pulsatile pumping method, gas or blood were pumped to have pulsation. The results showed that the oxygenation efficiency did not increase with pulsatile pumping of gas but had increasing tendency with pulsatile pumping of blood.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Presentation (2 results)

  • [Presentation] シリコーン中空糸のコンプライアンスを利用した人工肺の基礎研究2016

    • Author(s)
      原伸太郎
    • Organizer
      第55回日本生体医工学会大会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2016-04-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] シリコーン中空糸のコンプライアンスを利用した長期使用を目的とした人工肺の研究2015

    • Author(s)
      渡辺真吾
    • Organizer
      第53回日本人工臓器学会大会
    • Place of Presentation
      東京ドームホテル
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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