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Basic study of the relevance of programmed cell death in the maintenance and regulation of liver function and regeneration for the future clinical use.

Research Project

Project/Area Number 26670591
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionHokkaido University

Principal Investigator

Yi Min  北海道大学, 医学(系)研究科(研究院), 助教 (40292007)

Co-Investigator(Kenkyū-buntansha) HAGA Sanae  北海道大学, 保健科学研究院, 博士研究員 (60706505)
NODA Natusmi  東京大学, 理学研究科, 研究員 (30624358)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肝障害 / プログラム細胞死 / 光プローブ / 再生 / 細胞死 / 機能維持 / イメージング / 昨日維持
Outline of Final Research Achievements

Liver regeneration is an essential event in the treatment of various liver diseases. Most therapeutic strategies are based on the natural regenerative capability of liver. However, the precise mechanisms of liver regeneration have not fully elucidated. Here, we tried to study the roles of programmed cell death such as apoptosis, necroptosis and autophagy in post-hepatectomy liver regeneration.
We designed and developed our original optic probes for apoptosis, necroptosis and autophagy (based on molecular mechanism of caspase, necroptosis and autophagy pathway, respectively). Some of these probes functioned at least hepatic cells in the in vitro system. We examined the functions of the apoptotic activity probe with Fas-induced acute liver failure model in mouse as well as cell experiments. The probe for apoptotic activity was proved to be sufficient for even in vivo assay. We hope to elucidate the physio-pathology of various liver conditions by these probes.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results) (of which Invited: 2 results)

  • [Journal Article] Long-term ex vivo and in vivo monitoring of tumor progression by using dual luciferases.2016

    • Author(s)
      Naoki Morita, Sanae Haga, Yoshihiro Ohmiya, Michitaka Ozaki.
    • Journal Title

      Analytical Chemistry

      Volume: 497 Pages: 24-26

    • DOI

      10.1016/j.ab.2015.12.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory effect of interleukin-4 in the innate inflammatory response to rhodococcus aurantiacus infection in mice.2015

    • Author(s)
      Yimin, Kohanawa M, Zhao S, Li M, Kuge Y, Tamaki N, Watanabe M
    • Journal Title

      J Interferon Cytokine Res.

      Volume: 35 Issue: 3 Pages: 222-231

    • DOI

      10.1089/jir.2014.0107

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial delivery of Coenzyme Q via systemic administration using a MITO-Porter prevents ischemia/reperfusion injury in the mouse liver.2015

    • Author(s)
      Yamada Y, Nakamura K, Abe J, Hyodo M, Haga S, Ozaki M, Harashima H.
    • Journal Title

      Journal of controlled release

      Volume: 10 Pages: 86-95

    • DOI

      10.1016/j.jconrel.2015.06.037

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gadd34 regulates liver regeneration in hepatic steatosis.2015

    • Author(s)
      Yuka Inaba, Tomoko Furutani, Kumi Kimura, Hitoshi Watanabe, Sanae Haga, Yoshiaki Kido, Michihiro Matsumoto, Yasuhiko Yamamoto, Kenichi Harada, Shuichi Kaneko, Seiichi Oyadomari, Michitaka Ozaki, Masato Kasuga, Hiroshi Inoue.
    • Journal Title

      Hepatology

      Volume: 61 Pages: 1343-1356

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] p62/SQSTM1 plays a protective role in oxidative injury of steatotic liver in a mouse hepatectomy model.2014

    • Author(s)
      Sanae Haga, Takeaki Ozawa, Yuma Yamada, Naoki Morita, Izuru Nagashima, Hiroshi Inoue, Yuka Inaba, Natsumi Noda, Riichiro Abe, Kazuo Umezawa, Michitaka Ozaki.
    • Journal Title

      Antioxid Redox Signal

      Volume: 21 Pages: 2515-2530

    • NAID

      120005677747

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anoikis induction and inhibition of peritoneal metastasis of pancreatic cancer cells by a nuclear factor-kappa B inhibitor, (-)-DHMEQ.2014

    • Author(s)
      Masanori Sato, Kazuaki Nakanishi, Sanae Haga, Masato Fujiyoshi, Motoi Baba, Kazuhiro Mino, Yimin, Haruki Niwa, Hideki Yokoo, Kazuo Umezawa, Yoshihiro Ohmiya, Toshiya Kamiyama, Satoru Todo, Akinobu Taketomi, Michitaka Ozaki.
    • Journal Title

      Oncology Research

      Volume: 21 Pages: 333-343

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] p62/SQSTM1 を基軸とした新たな肝臓・肝細胞保護・機能維持法の探索2015

    • Author(s)
      尾崎 倫孝、芳賀 早苗、森田 直樹、伊 敏.
    • Organizer
      第42回日本臓器保存生物医学会学術集会
    • Place of Presentation
      いわて県民情報交流センター アイーナ (岩手県盛岡)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝臓における早期サイトカインの感染性肉芽腫性炎症への寄与2015

    • Author(s)
      伊敏
    • Organizer
      第80回日本インターフェロン・サイトカイン学会
    • Place of Presentation
      東京工業大学 (東京都目黒区)
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] “光”を利用した肝細胞機能制御技術の開発2015

    • Author(s)
      芳賀 早苗、小澤 岳昌、森田 直樹、野田 なつみ、尾崎 倫孝.
    • Organizer
      第22回肝細胞研究会
    • Place of Presentation
      米子コンベンションセンター (鳥取県米子市)
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] “光” を利用した新たな細胞・臓器保存法の開発2014

    • Author(s)
      芳賀 早苗、小澤 岳昌、森田 直樹、野田 なつみ、尾崎 倫孝.
    • Organizer
      第41回日本臓器保存生物医学会学術集会 平成25 年度日本臓器保存生物医学会奨励賞 受賞記念講演
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府・豊中市)
    • Year and Date
      2014-11-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 肝臓のストレス応答(傷害と再生)について -脂肪肝からNASHへ-2014

    • Author(s)
      尾崎 倫孝、芳賀 早苗、小澤 岳昌.
    • Organizer
      国立病院機構福山医療センター
    • Place of Presentation
      国立病院機構福山医療センター熊ヶ峰ホール(広島県・福山市)
    • Year and Date
      2014-10-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 光イメージング技術を用いた肝病態の解析2014

    • Author(s)
      尾崎 倫孝、芳賀 早苗、野田 なつみ、森田 直樹、小澤 岳昌
    • Organizer
      第21回肝細胞研究会
    • Place of Presentation
      東京医科歯科大学(東京都・文京区)
    • Year and Date
      2014-06-27 – 2014-06-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 光を応用した移植細胞機能・細胞環境のモニタリングと制御の試み2014

    • Author(s)
      尾崎 倫孝、芳賀 早苗、野田 なつみ、森田 直樹、服部 満、小澤 岳昌
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      国立京都国際会館(京都府・京都市)
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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