| Project/Area Number |
26670594
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
Unno Michiaki 東北大学, 医学(系)研究科(研究院), 教授 (70282043)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OHTSUKA HIDEO 東北大学病院, 肝胆膵外科, 助教 (50451563)
ARIAKE KYOHEI 東北大学病院, 肝胆膵外科, 助教 (10754921)
|
|---|
| Research Collaborator |
DOUCHI DAISUKE 東北大学, 大学院生
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 膵癌 / 上皮間葉転換 / 抗癌剤感受性 / Wnt signal / 循環腫瘍細胞 / EMT / 腫瘍循環細胞 / 上皮間葉移行 / Wntシグナル |
|---|
| Outline of Final Research Achievements |
Outcome of pancreatic cancer is very miserable due to the recurrence of distant metastasis. The distant metastases were associated with epithelial-mesenchymal transition (EMT) . In this study, we examined the relationship between Wnt signal and EMT, and also relationship if EMT and sensitivity of anti-cancer drug.
When Wnt signal was inhibited by introducing SiRNA of LRRFIP1 into pancreatic cancer cell line Panc-1, we showed that reverse EMT was observed. Moreover, we revealed that the sensitivity of anti-cancer drug was increased in this situation. Therefore, we indicated that there was a strong relationship between the EMT and sensitivity for anti-cancer drugs in pancreatic cancer cells.
|
