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Biomarker of the colorectal cancer in inflammatory bowel decease patients.

Research Project

Project/Area Number 26670598
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionThe University of Tokyo

Principal Investigator

SUNAMI EIJI  東京大学, 医学部附属病院, 登録研究員 (70345205)

Co-Investigator(Kenkyū-buntansha) ISHIHARA SOICHIRO  東京大学, 医学部付属病院, 講師 (00376443)
YAMAGUCHI HIRONORI  東京大学, 医学部付属病院, 登録研究員 (20376445)
WATANABE TOSHIAKI  東京大学, 医学部付属病院, 教授 (80210920)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords炎症性腸疾患 / 大腸がん / バイオマーカー / 遊離DNA / LINE1 / サーベイランス
Outline of Final Research Achievements

Inflammatory Bowel decease (IBD) may cause colorectal cancer after long disease duration. In this study, the possibility of early detection of the colorectal cancer by means of the blood, feces and biopsy is investigated. In this study, we quantified the global methylation status of cfDNA in plasma extracted from colorectal cancer (CRC) patients, and investigated its clinical usefulness as a biomarker. LINE-1 hypomethylation index (LHI) in plasma may have a potential to serve as a biomarker enabling us to detect CRC patient at early stage. By means of the biopsy specimen, early onset of LINE-1 demethylation during adenomatous change of colorectal epithelial cells and LINE-1 demethylation progression is linear to TNM stage progression are demonstrated. LINE-1 hypomethylation is also detected from the material of the feces and regarding the utilization of this specimen, further analyses of the data are necessary.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Incidence of neoplasias and effectiveness of post operative surveillance endoscopy for patients with ulcerative colitis: comparison of ileorectal anastomosis and ileal pouch-anal anastomosis.2016

    • Author(s)
      Ishii H, Hata K, Kishikawa J, Anzai H, OtaniK, Yasuda K, Nishikawa T, Tanaka T, Tanaka J Kiyomatsu T, Kawai K, Nozawa H, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Kitayama j, Watanabe T
    • Journal Title

      World Journal of Surgical Oncology

      Volume: 14 Issue: 1 Pages: 833-835

    • DOI

      10.1186/s12957-016-0833-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surveillance colonoscopy for colitis-associated dysplasia and cancer in ulcerative colitis patients.2015

    • Author(s)
      Hata K, Kishikawa J, Anzai H, Shinagawa T, Kazama S, Ishii H, Nozawa H, Kawai K, Kiyomatsu T, Tanaka J, Tanaka T, Nishikawa T, Otani K, Yasuda K, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      Dig Endosc

      Volume: 28 Issue: 3 Pages: 260-5

    • DOI

      10.1111/den.12505

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tracheobronchitis with Dyspnea in a Patient with Ulcerative Colitis2015

    • Author(s)
      Hiyoshi M, Kawai K, Shibuya M, Ozawa T, Kishikawa J, Nirei T, Tanaka T, Tanaka J, Kiyomatsu T, Tada T, Kanazawa T, Kazama S, Shoda H, Sumitomo S, Kubo K, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Yamamoto K, Watanabe T.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 7 Pages: 749-753

    • DOI

      10.2169/internalmedicine.54.3142

    • NAID

      130005063203

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Laparoscopic surgery for ulcerative colitis: a review of the literature.2015

    • Author(s)
      Hata K, Kazama S, Nozawa H, Kawai K, Kiyomatsu T, Tanaka J, Tanaka T, Nishikawa T, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      Surg Today

      Volume: Epub ahead of print

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The laser capture microdissection cannot be replaced with the macrodissection.2014

    • Author(s)
      Sunami E, Watanabe T.
    • Journal Title

      Exp Mol Patho

      Volume: 96 Issue: 2 Pages: 206-206

    • DOI

      10.1016/j.yexmp.2014.01.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] LINE-1 hypomethylation of circulating cell-free DNA in plasma has a potential to serve as a biomarker for detecting colorectal cancer patient2015

    • Author(s)
      Yuzo Nagai, Eiji Sunami, Yoko Yamamoto, Koji Yasuda, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Junichiro Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa, Hironori Yamaguchi, Soichiro Ishihara, Joji Kitayama, Toshiaki Watanabe
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Year and Date
      2015-07-15
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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