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Elucidation of the role of microRNA as a cancer treatment-resistant mechanism by autophagy

Research Project

Project/Area Number 26670607
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

NAKATA Kohei  九州大学, 大学病院, 特別教員 (30419569)

Co-Investigator(Kenkyū-buntansha) MAEYAMA Ryo  九州大学, 医学研究院, 共同研究員 (10611668)
NAGAI Eishi  九州大学, 医学研究院, 准教授 (30264021)
EGAMI Takuya  九州大学, 医学研究院, 共同研究員 (40507787)
MIYASAKA Yoshihiro  九州大学, 医学研究院, 助教 (40507795)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsオートファジー / マイクロRNA / 膵臓癌
Outline of Final Research Achievements

As the existing chemotherapy has little effect on cancer stem cells, which have remained in the stationary phase, mechanism elucidation of the cancer stem cells is expected. It was recently reported that autophagy is involved in the maintenance of blood stem cells, and we have been reporting the relationship between the micro-RNA and pancreatic cancer malignancy. From these, we study the involvement of cancer stem cells maintenance mechanism by autophagy and micro-RNA.
We established the evaluation method of autophagy and the stemness of pancreatic cancer cells. Further, we reported that micro RNA-373 suppressed the invasion of cancer cells, through the inhibition of the epithelial-mesenchymal transition. We also reported that overexpression of micro RNA-5100 reduced colony-forming, invasion, and migration ability of pancreatic cancer cells.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility2016

    • Author(s)
      Sada M, Ohuchida K, Horioka K, Okumura T, Moriyama T, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Nakamura M
    • Journal Title

      Cancer Lett.

      Volume: 372 Issue: 2 Pages: 210-218

    • DOI

      10.1016/j.canlet.2016.01.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Suppression of CD51 in pancreatic stellate cells inhibits tumor growth by reducing stroma and altering tumor-stromal interaction in pancreatic cancer2016

    • Author(s)
      Horioka K, Ohuchida K, Sada M, Zheng B, Moriyama T, Fujita H, Manabe T, Ohtsuka T, Shimamoto M, Miyazaki T, Mizumoto K, Oda Y, Nakamura M.
    • Journal Title

      Int J Oncol

      Volume: 48 Issue: 4 Pages: 1499-1508

    • DOI

      10.3892/ijo.2016.3374

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Overexpression of microRNA-5100 decreases the aggressive phenotype of pancreatic cancer cells by targeting PODXL.2016

    • Author(s)
      Chijiiwa Y, Moriyama T, Ohuchida K, Nabae T, Ohtsuka T, Miyasaka Y, Fujita H, Maeyama R, Manabe T, Abe A, Mizuuchi Y, Oda Y, Mizumoto K, Nakamura M
    • Journal Title

      Int J Oncol

      Volume: 48 Issue: 4 Pages: 1688-1700

    • DOI

      10.3892/ijo.2016.3389

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 膵癌におけるmiRNA発現と上皮間葉転換2015

    • Author(s)
      仲田興平、大内田研宙、大塚隆生、中村雅史
    • Journal Title

      胆と膵

      Volume: 36 Pages: 1117-1122

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Micro RNA-373 is Down-regulated in Pancreatic Cancer and Inhibits Cancer Cell Invasion2014

    • Author(s)
      Nakata K, Ohuchida K, Mizumoto K, Aishima S, Oda Y, Nagai E, Tanaka M
    • Journal Title

      Ann Surg Oncol

      Volume: 21 Issue: S4 Pages: 564-574

    • DOI

      10.1245/s10434-014-3676-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Pancreatic Stellate Cells Lead and Promote the Local Invasion of Cancer Cells, by Physically Remodeling the Extracellular Matrix with Collagen Fiber Alignment in Pancreatic Cancer2015

    • Author(s)
      Koikawa K, Ohuchida K, Sada M, Abe T, Endo S, Horioka K, Moriyama T, Miyasaka Y, Ohtsuka T, Ohuchida R, Ueki T, Nagai E, Mizumoto K, Nakamura M
    • Organizer
      American Pancreatic Association 46th Annual Meeting
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2015-11-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Suppression of CD51 in Pancreatic Stellate Cells Inhibits Tumor Growth by Reducing Stroma and Altering Tumor-Stromal Interaction in Pancreatic Cancer2015

    • Author(s)
      Horioka K, Ohuchida K, Sada M, Zheng B, Ohtsuka T, Ueki T, Nagai E, Mizumoto K, Oda Y, Nakamura M
    • Organizer
      American Pancreatic Association 46th Annual Meeting
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2015-11-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オートファジーが膵癌の癌間質相互作用に与える影響の検討2015

    • Author(s)
      遠藤翔、仲田興平、大内田研宙、阿部俊也、肥川和寛、堀岡宏平、水内祐介、小田義直、水元一博、田中雅夫
    • Organizer
      第46回日本膵臓学会大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膵癌肝転移に関わるmicroRNAの検討2015

    • Author(s)
      千々岩芳朗、大内田研宙、水元一博、田中雅夫
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膵癌の肝転移におけるfollistatin-like1の役割2014

    • Author(s)
      堀岡宏平、大内田研宙、江口大樹、佐田政史、田中友晴、赤川進、藤原謙次、鄭彪、仲田興平、宮坂義浩、前山良、大塚隆生、水元一博、田中雅夫
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2014-04-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 膵癌におけるTM4SF1発現の意義2014

    • Author(s)
      鄭彪、崔林、大内田研宙、進藤幸治、藤原謙次、赤川進、堀岡宏平、田中友晴、佐田政史、吉田真樹、千々岩芳朗、奥村隆志、仲田興平、大塚隆生、小田義直、水元一博、田中雅夫
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2014-04-04
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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