| Project/Area Number |
26670609
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital (2015-2016)
Kitasato University (2014) |
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Principal Investigator |
Futawatari Nobue 独立行政法人国立病院機構(相模原病院臨床研究センター), 外科, 医長 (40306600)
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| Co-Investigator(Kenkyū-buntansha) |
福山 隆 北里大学, 北里大学メディカルセンター, 上級研究員 (10462251)
山崎 等 北里大学, 北里大学メディカルセンター, 教授 (20191273)
高橋 禎人 北里大学, 医学部, 講師 (80245406)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 胃癌 / 癌/精巣抗原 / KK-LC-1 / Helicobacter pylori / メチル化 / 早期胃癌 / 癌精巣抗原 / ヘリコバクターピロリ |
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| Outline of Final Research Achievements |
There were few report about KK-LC-1 except for lung cancer. This study showed that KK-LC-1 was expressed in gastric cancer and its expression rate was 82% （Shida A, Futawatari N, et al. Frequent High Expression of Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1) in Gastric Cancer. Anticancer res 2015；35：3575-3580）. Furthermore, its high-rate expression correlated with the serum antibody against Helicobacter pylori （H. pylori）, (Fukuyama T, Futawatari N, et al. Correlation Between Expression of Cancer/Testis Antigen KK-LC-1 and Helicobacter pylori Infection in Gastric Cancer. In Vivo 2017; 31; 403-407）. The conclusion of this study is that KK-LC-1 is one of cancer/testis antigens and its expression would be induced by infection of H. pylori.
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