| Project/Area Number |
26670611
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
SHIIBA KENICHI 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (90196345)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMA Hiroshi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 部長 (10196462)
TANUMA Nobuhiro 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | がん / 代謝 / ワールブルグ効果 / 大腸がん / 低酸素 / 低栄養 / ゲノム不安定性 |
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| Outline of Final Research Achievements |
Possible interplay between metabolism and genomic instability during epithelial oncogenesis have been evaluated. We isolated and purified epithelial cells of Pkm gene-targeting mice, then transformed them by active mutants of Kras and EGFR. Transplantation experiments of these cells into nude mice revealed important roles for metabolic remodeling directed by Pkm.
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