| Project/Area Number |
26670621
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Kurume University |
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Principal Investigator |
AOKI Hiroki 久留米大学, 循環器病研究所, 教授 (60322244)
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| Co-Investigator(Kenkyū-buntansha) |
KANAYAMA Shuri 昭和大学, 医学部, 講師 (10338535)
TANAKA Hiroyuki 久留米大学, 医学部, 教授 (70197466)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 大動脈解離 / ストレス応答 / 遺伝子発現 / 機械的ストレス / 循環器・高血圧 / シグナル伝達 / 細胞・組織 / 生体分子 / 発現制御 |
|---|
| Outline of Final Research Achievements |
Aortic dissection is a medical emergency, in which patients frequently suffer from a sudden death. Currently, no specific non-surgical therapy is available for aortic dissection, because the etiology and pathogenesis is largely unknown. In this study we demonstrated that MRTF-A, an intracellular stress sensor, translates the mechanical and humoral stress to the tissue destructive response that eventually causes aortic dissection. MRTF-A inhibitor effectively prevented the development of aortic dissection, showing that MRTF-A is a promising therapeutic target.
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