| Project/Area Number |
26670622
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular surgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Takewa Yoshiaki 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (20332405)
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| Co-Investigator(Renkei-kenkyūsha) |
TATSUMI Eisuke 国立研究開発法人国立循環器病研究センター, 研究所, 部長 (00216996)
NAKAYAMA Yasuhide 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (50250262)
SUMIKURA Hirohito 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 (20433998)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ステントバルブ / TAVI / 経皮的心臓弁置換 / 自己組織由来心臓弁 / 組織工学 / 生体弁 |
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| Outline of Final Research Achievements |
We are developing a novel autologous heart valve (biovalve), using in-body tissue engineering which is based on a tissue encapsulation phenomenon in the living body. Recently percutaneous trans catheter valve implantation is clinically used with stent valves. We developed a stent biovalve which consists of biovalve and a metallic stent in order to achieve both easiness of application and better biocompatibility. In this study, a feasibility of the stent biovalve for transcatheter implantation was evaluated in a large animal model. Stent biovalve was made from autologous connective tissues and metalic stent. Stent biovalves were successfully implanted in the aortic and pulmonary arterial position. Biovalves kept their function over 12 months. The stent biovalves satisfied the higher requirements of systemic and pulmonary circulation and have a potential as next generation valvular substitutes.
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