The feasibility study of a novel autologous heart valve (biovalve stent)
Project/Area Number |
26670622
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular surgery
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
Takewa Yoshiaki 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (20332405)
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Co-Investigator(Renkei-kenkyūsha) |
TATSUMI Eisuke 国立研究開発法人国立循環器病研究センター, 研究所, 部長 (00216996)
NAKAYAMA Yasuhide 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (50250262)
SUMIKURA Hirohito 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 (20433998)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | ステントバルブ / TAVI / 経皮的心臓弁置換 / 自己組織由来心臓弁 / 組織工学 / 生体弁 |
Outline of Final Research Achievements |
We are developing a novel autologous heart valve (biovalve), using in-body tissue engineering which is based on a tissue encapsulation phenomenon in the living body. Recently percutaneous trans catheter valve implantation is clinically used with stent valves. We developed a stent biovalve which consists of biovalve and a metallic stent in order to achieve both easiness of application and better biocompatibility. In this study, a feasibility of the stent biovalve for transcatheter implantation was evaluated in a large animal model. Stent biovalve was made from autologous connective tissues and metalic stent. Stent biovalves were successfully implanted in the aortic and pulmonary arterial position. Biovalves kept their function over 12 months. The stent biovalves satisfied the higher requirements of systemic and pulmonary circulation and have a potential as next generation valvular substitutes.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] In-body tissue engineered aortic valve (Biovalve type VII) architecture based on 3D printer molding2014
Author(s)
Nakayama Y, Takewa Y, Sumukura H, Yamanami M, Matsui Y, Oie T, Kishimoto Y, Arakawa M, Ohnuma K, Kanda K, Tatsumi E
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Journal Title
J Biomed Mater Res B Appl Biomater
Volume: (in press)
Issue: 1
Pages: 1-10
DOI
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Peer Reviewed / Open Access
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[Presentation] Development of in vivo, tissue-engineered, autologous, 3D heart valvular tissue, type SC biovalve with excellent mechanical properties, valvular functions, and in vivo performances2015
Author(s)
Nakayama Y, Takewa Y, Moriwaki T, Sumikura H, Miyamoto S, Funayama M, Furukoshi M, Tatsumi E
Organizer
American Heart Association Scientific Sessions 2015
Place of Presentation
オーランド
Year and Date
2015-11-07
Related Report
Int'l Joint Research
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[Presentation] Development of a novel autologous heart valve (biovalve stent) for transcatheter implantation.2014
Author(s)
Takewa Y, Ohnuma K, Sumikura H, Homma A, Tsukiya T, Takewa Y, Mizuno T, Katano K, Kojima K, Mukaibayashi H, Taenaka Y, Tatsumi E
Organizer
ESAO(欧州人工臓器学会)
Place of Presentation
ローマ
Year and Date
2014-10-17 – 2014-10-20
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[Presentation] Key factors to develop histogenesis in a novel autologous heart valve implantation.2014
Author(s)
Takewa Y, Nakayama Y, Sumikura H, Kishimoto S, Date K, Wieloch R, Kanada K, Tajikawa T, Tanaka T, Tatsumi E
Organizer
ESC(European Society of Cardiology, 欧州心臓病学会)
Place of Presentation
バルセロナ
Year and Date
2014-08-30 – 2014-09-03
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[Presentation] Long term evaluation of in-body tissue engineered heart valve (Biovalve)2014
Author(s)
Takewa Y, Nakayama Y, Kishimoto S, Date K, Wieloch R, Sumikura H, Kanda K, Tajikawa T, Tanaka T, Taenaka Y, Tatsumi E
Organizer
International Congress of the European Society for Cardiovascular and EndoVascular Surgery
Place of Presentation
ニース(フランス)
Year and Date
2014-04-24 – 2014-04-27
Related Report