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Treatment of rat myocardial infarction by injecting thermoresponsive and biodegradable hydrogel with various properties

Research Project

Project/Area Number 26670623
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cardiovascular surgery
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Nakatani Takeshi  国立研究開発法人国立循環器病研究センター, 病院, 部長 (60155752)

Co-Investigator(Kenkyū-buntansha) YAMAOKA Tetsuji  国立研究開発法人国立循環器病研究センター, 研究所, 部長 (50243126)
KAKINOKI Sachiro  国立研究開発法人国立循環器病研究センター, 研究所, 研究員 (70421419)
JYO Yui  国立研究開発法人国立循環器病研究センター, 研究所, 流動研究員 (10757678)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords心筋梗塞 / ゲル治療 / アルギン酸 / ポリ乳酸 / ポリグリコール酸 / ミセル / 心筋疾患外科学
Outline of Final Research Achievements

Heart decease is one of the major causes of death in Japan. Recently a new therapeutic strategy in which relatively weak polymeric hydrogels are injected into the infarcted area of heart was proposed. It seems to stop the cardiac remodeling and loss of heart function. In the present project, PEG-poly(lactic acid) injectable hydrogels with various properties were injected to the rat myocardial infarction model, and the heart functions were monitored. The biodegradable hydrogel resulted in the recovered heart function as well as the conventional nondegradable hydrogels. However, the inflammation was much milder than the conventional hydrogel. It can be then concluded that the synthetic biodegradable thermoresponsive hydrogel can be a good material for treating myocardial infarction.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (21 results)

All 2015 2014

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 1 results) Book (2 results)

  • [Journal Article] Tuning of Sol-gel Transition in the Mixed Polymer Micelle Solutions of Copolymer Mixtures Consisting of Enantiomeric Diblock and Triblock Copolymers of Polylactide and Poly(ethylene glycol)2015

    • Author(s)
      Y.-I. Hsu, K. Masutani, T. Yamaoka, *Y. Kimura
    • Journal Title

      Macromolecular Chemistry and Physics

      Volume: 216 Issue: 8 Pages: 837-846

    • DOI

      10.1002/macp.201400581

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Strengthening of hydrogels made from enantiomeric block copolymers of polylactide (PLA) and poly(ethylene glycol) (PEG) by the chain extending Diels-Alder reaction at the hydrophilic PEG terminals2015

    • Author(s)
      Y.-I. Hsu, K. Masutani, T. Yamaoka, *Y. Kimura
    • Journal Title

      Polymer

      Volume: 67 Pages: 157-166

    • DOI

      10.1016/j.polymer.2015.04.026

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Size-controlled nanomicelles of poly(lactic acid)-poly(ethylene 7 glycol) copolymers with a multiblock configuration2015

    • Author(s)
      S. Somekawa, K. Masutani, Yu-I Hsu, A. Mahara, Y. Kimura and *T. Yamaoka
    • Journal Title

      Polymers

      Volume: 7 Issue: 6 Pages: 1177-1191

    • DOI

      10.3390/polym7061177

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum brain natriuretic peptide concentration 60 days after surgery as a predictor of long-term prognosis in patients implanted with a left ventricular assist device2015

    • Author(s)
      Sato T, Seguchi O, Iwashima Y, Yanase M, Nakajima S, Hieda M, Watanabe T, Sunami H, Murata Y, Hata H, Fujita T, Kobayashi J, Nakatani T
    • Journal Title

      ASAIO Journal

      Volume: 61 Issue: 5 Pages: 373-378

    • DOI

      10.1097/mat.0000000000000237

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strengthening of hydrogels made from enantiomeric block copolymers of polylactide (PLA) and poly(ethylene glycol) (PEG) by the chain extending Diels-Alder reaction at the hydrophilic PEG terminals2015

    • Author(s)
      Yu-I Hsu, Kazunari Masutani, Tetsuji Yamaoka, Yoshiharu Kimura
    • Journal Title

      Polymer

      Volume: in press

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comprehensive Genetic Analysis of Early Host Body Reactions to the Bioactive and Bio-Inert Porous Scaffolds2014

    • Author(s)
      T. Ehashi, T. Takemura, N. Hanagata, T. Minowa, H. Kobayashi, K. Ishihara, and T. Yamaoka
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 1 Pages: e85132-e85132

    • DOI

      10.1371/journal.pone.0085132

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thermoresponsive elastin/laminin mimicking artificial protein for modifying PLLA scaffolds in nerve regeneration2014

    • Author(s)
      S. Kakinoki and T. Yamaoka
    • Journal Title

      Journal of Materials Chemistry B

      Volume: 2 Issue: 31 Pages: 5061-5067

    • DOI

      10.1039/c4tb00305e

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term/bioinert labeling of rat mesenchymal stem cells with PVA-Gd conjugates and MRI monitoring of the labeled cell survival after intramuscular transplantation.2014

    • Author(s)
      Tachibana Y, Enmi J, Agudelo CA, Iida H, Yamaoka T
    • Journal Title

      Bioconjugate Chemistry

      Volume: 25 Issue: 7 Pages: 1243-1251

    • DOI

      10.1021/bc400463t

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three-layer microfibrous peripheral nerve guide conduit composed of elastin-laminin mimetic artificial protein and poly(L-lactic acid)2014

    • Author(s)
      S. Kakinoki, M. Nakayama, T. Moritan, and T. Yamaoka
    • Journal Title

      Front. Chem.

      Volume: 2 Pages: 38-45

    • DOI

      10.3389/fchem.2014.00052

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Water absorbing and quick degradable PLLA/PEG multiblock copolymers reduced encapsulation and inflammatory cytokine production2014

    • Author(s)
      T. Ehashi, S. Kakinoki, and T. Yamaoka
    • Journal Title

      Journal of Artificial Organs

      Volume: 17 Issue: 4 Pages: 321-328

    • DOI

      10.1007/s10047-014-0791-z

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] PLA-PEGハイドロゲルによる慢性心筋梗塞後の心機能の改善と左室拡大抑制2015

    • Author(s)
      染川将太、馬原 淳、増谷一成、木村良晴、山岡哲二
    • Organizer
      平成27年度 繊維学会秋季研究発表会
    • Place of Presentation
      京都
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Size control of poly(lactic acid-b-ethylene glycol) micelles by their multiblock structure2015

    • Author(s)
      Shota Somekawa, Kazunari Masutani, Yu-I Hsu, Atsushi Mahara, Yoshiharu kimura, Tetsuji Yamaoka
    • Organizer
      第64回高分子年次大会
    • Place of Presentation
      札幌
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Tuning of gel properties by chainextension and improved applicability of the mixed aqueous dispersions consisting of polylactide-poly(ethylene glycol) diblock and triblock copolymers as cell-injectable scaffolds2015

    • Author(s)
      Yu-I Hsu, Takashi Aoki, Yoshiharu Kimura, Y, Tetsuji Yamaoka
    • Organizer
      The 5th Asian Biomaterials Congress
    • Place of Presentation
      Taipei
    • Year and Date
      2015-05-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エラスチン-ラミニン模倣人工細胞外マトリクス混合ポリ乳酸ファイバーよりなる 神経再生用スキャホールドの開発2015

    • Author(s)
      柿木佐知朗
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学理工学部船橋キャンパス
    • Year and Date
      2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 血管誘導能を有するフィブロインゲルの作製と応用2015

    • Author(s)
      神戸裕介
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 血管誘導機能を有したシルクフィブロインゲル2014

    • Author(s)
      神戸裕介
    • Organizer
      第24回日本MRS年次大会
    • Place of Presentation
      横浜市開港記念会館
    • Year and Date
      2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 機能性リコンビナントタンパク質によるシルクゲルへの血管誘導機能の付加2014

    • Author(s)
      神戸裕介
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 細胞注入足場材料に用いるポリ乳酸-b-ポリエチレングリコールのゾルーゲル転移と鎖延長制御2014

    • Author(s)
      徐 于懿
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2014-05-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 心筋梗塞治療を目指したポリ乳酸/ポリエチレングリコール共重合体温度応答性インジェクタブルハイドロゲルの合成と物性評価2014

    • Author(s)
      染川将太
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2014-05-28
    • Related Report
      2014 Research-status Report
  • [Book] バイオマテリアル研究の最前線2014

    • Author(s)
      山岡哲二
    • Total Pages
      2
    • Publisher
      日本金属学会
    • Related Report
      2014 Research-status Report
  • [Book] 医療用バイオベースマテリアル2014

    • Author(s)
      染川将太、山岡哲二
    • Total Pages
      9
    • Publisher
      シーエムシー出版
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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