| Project/Area Number |
26670626
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
DATE Hiroshi 京都大学, 医学(系)研究科(研究院), 教授 (60252962)
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| Co-Investigator(Kenkyū-buntansha) |
MENJYU Toshi 京都大学, 大学院医学研究科, 助教 (30527081)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Kinome / 肺癌転移能 / EMT / 特異的抗体 / in vivo selection法 / HARA細胞 / Lewis株 / H460 / PC14 |
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| Outline of Final Research Achievements |
The molecular markers associated with tumor metastasis were compared between the parental lung cancer cell lines and the highly metastatic cells which were induced by in vivo selection methods. Highly metastatic cells originated from PC14 showed the loss of E-cadherin expression and the gain of Vimentin expression, showing its EMT phenotype. The other three cells did not show such phenomenon. The kinome analysis could not be performed due to its patent problem.
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