Basic researches for the improvement of the fragility and the organ portection about de-and re-cellularization based regenerated lung
| Project/Area Number |
26670629
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
TSUCHIYA Tomoshi 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (30437884)
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| Co-Investigator(Kenkyū-buntansha) |
下川 功 長崎大学, 医歯薬学総合研究科(医学系), 教授 (70187475)
山崎 直哉 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (70404217)
永安 武 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80284686)
樋上 賀一 東京理科大学, 薬学部生命創薬科学科, 教授 (90253640)
秋田 定伯 福岡大学, 医学部, 教授 (90315250)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 肺再生 / 肺 / 再生 / 組織工学 / 脱細胞化 / 再細胞化 / 肺移植 / マトリックス / バイオリアクター |
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| Outline of Final Research Achievements |
Decellularization and recellularization technique is the most useful for lung regeneration. The aim of the present study was to regenerate lung using the technique and the main subjects were improvement of the decellularization method including decellularization route and decellularization solution. As results, we developed the NaOH based decellularization solution; the matrix damage was similar to original method and the total cost of the method was reduced. We could also developed ventilation-based decellularization system of the lung. The live imaging of the recellularization represented that adipose tissue derived stromal cells migrated stroma and differentiated into pericytes.
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Report
(4 results)
Research Products
(9 results)
