| Project/Area Number |
26670630
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
SAHARA HISASHI 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 准教授 (90452333)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Kazuhiko 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 教授 (40241103)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Akira 日本医科大学, 医学部, 教授 (00256942)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 移植・再生医療 / 臓器保存 / 高圧 / 非凍結 / クラウン系ミニブタ / 肺移植 / 前臨床研究 / 虚血再灌流障害 |
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| Outline of Final Research Achievements |
To extend organ preservation time, we attempted to establish a new preservation method in a stable unfrozen state below the freezing point by highly-pressurizing the solution. To clarify the effects of high pressure on the lung, we performed MHC-matched lung transplantation in CLAWN miniature swine using the pulmonary grafts preserved under high pressure (30-60 MPa). The lung grafts preserved under pressurize (subzero non-frozen condition) showed severe ischemia-reperfusion injury after orthotopic left lung transplantation suggesting that the control of remaining air in the lung graft could be the most important to establish this new organ preservation method.
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