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Development of ALA-PET guided sonodynamic therapy for malignant gliomas

Research Project

Project/Area Number 26670632
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionHokkaido University

Principal Investigator

KOBAYASHI HIROYUKI  北海道大学, 大学病院, 講師 (70374478)

Co-Investigator(Kenkyū-buntansha) TERASAKA SHUNSUKE  北海道大学, 医学研究科, 准教授 (10447055)
KUDO NOBUKI  北海道大学, 情報科学研究科, 准教授 (30271638)
SHIGA TORU  北海道大学, 医学研究科, 准教授 (80374495)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords神経膠腫 / 音響力学療法 / ポルフィリン誘導体 / アミノレブリン酸 / PET / 超音波 / 悪性神経膠腫 / 悪性脳腫瘍
Outline of Final Research Achievements

Malignant glioma is a poor prognosis cancer despite of multidisciplinary treatment such as aggressive surgery and chemoradiotherapy. Thus there has been a need for new therapeutic approaches to control deeply migrated tumor cells. For this aim, we investigated the efficacy of sonodynamic therapy (SDT) using sonosensitizers including 5-aminolevulinic acid, protoporphyrinⅨ, and talaporfin sodium on glioma cells. These substances have been known to be accumulated in glioma cell and are expected to have cytotoxic effect by sonication. Our in vitro study demonstrated that the cytotoxicity of sonication on glioma cells was enhanced by each sonosensitizers. And induction of apoptosis was suggested to be a major mechanism of cell death. While the efficacy of SDT may be depend on the degree of intracellular accumulation of sonosensitizer. Though further investigations will be necessary, our preliminary result showed a potential of STD with sonosensitizers for glioma treatment.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Porphyrin derivatives-mediated sonodynamic therapy for malignant gliomas in vitro.2015

    • Author(s)
      Endo S, Kudo N, Yamaguchi S, Sumiyoshi K, Motegi H, Kobayashi H, Terasaka S, Houkin K
    • Journal Title

      Ultrasound in Medicine & Biology

      Volume: 41(9) Issue: 9 Pages: 2458-65

    • DOI

      10.1016/j.ultrasmedbio.2015.05.007

    • NAID

      120005828507

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 悪性神経膠腫細胞株に対するポルフィリン誘導体を用いた音響力学療法2015

    • Author(s)
      遠藤将吾、工藤信樹、山口秀、住吉洸城、茂木洋晃、金子貞洋、小林浩之、寺坂俊介、寳金清博
    • Organizer
      第14回日本超音波治療研究会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県高知市)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 悪性神経膠腫細胞株に対するポルフィリン誘導体を用いた音響力学療法2015

    • Author(s)
      遠藤将吾、工藤信樹、山口秀、住吉洸城、茂木洋晃、金子貞洋、小林浩之、寺坂俊介、寳金清博
    • Organizer
      日本脳神経外科学会第74回学術総会
    • Place of Presentation
      ロイトン札幌、さっぽろ芸術文化の館、札幌市教育文化会館(北海道札幌市)
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 悪性神経膠腫細胞株に対するポルフィリン誘導体を用いた音響力学療法2015

    • Author(s)
      遠藤将吾、工藤信樹、山口秀、住吉洸城、茂木洋晃、金子貞洋、小林浩之、寺坂俊介、寳金清博
    • Organizer
      第2回アコースティックイメージング研究会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2015-08-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 悪性神経膠腫細胞株に対するポルフィリン誘導体を用いた音響力学療法2015

    • Author(s)
      遠藤将吾、工藤信樹、山口秀、住吉洸城、茂木洋晃、金子貞洋、小林浩之、寺坂俊介、寳金清博
    • Organizer
      第34回日本脳神経超音波学会総会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Porphyrin Derivatives Mediated Sonodynamic Therapy on Malignant Glioma Cells in Vitro2014

    • Author(s)
      遠藤将吾、小林浩之、寺坂俊介
    • Organizer
      2nd International ALA and porphyrin Symposium
    • Place of Presentation
      東京大学医科学研究所(東京都)
    • Year and Date
      2014-11-16
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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