An attempt to create an animal model for glioblastoma cure via proving the hypothesis that glucose metabolism serves as a rheostat to determine the cell fate of cancer stem cells
| Project/Area Number |
26670635
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKADA MASASHI 山形大学, 医学部, 講師 (70512614)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | glioma-initiating cell / 神経膠芽腫 |
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| Outline of Final Research Achievements |
Glucose metabolism is often increased in human cancers, the significance of which for cancer cells remains mostly unclear. In this project, we conducted experiments to test the working hypothesis that glucose metabolism serves as a rheostat to determine the cell fate of glioblastoma stem cells. Inhibition of glucose metabolism through the inhibition of GLUT1, a facilitative glucose transporter, resulted in increased intracellular reactive oxygen species (ROS) level as well as in the loss of the stem cell properties of glioblastoma stem cells, which suggested the possibility that glucose metabolism could contribute to the maintenance of glioblastoma stem cells through the modulation of intracellular ROS level.
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Report
(3 results)
Research Products
(8 results)
