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Molecular subclassification of glioblastoma based on the absolute quantitative proteomics

Research Project

Project/Area Number 26670638
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionKanazawa University

Principal Investigator

NAKADA MITSUTOSHI  金沢大学, 医学系, 教授 (20334774)

Co-Investigator(Renkei-kenkyūsha) TERASAKI TETSUYA  東北大学, 薬学部, 教授 (60155463)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords膠芽腫 / プロテオミクス / チロシンキナーゼ / 分類
Outline of Final Research Achievements

The purpose of this study is to attempt to classify GBM subtypes based on the molecular profile determined by absolute quantitative proteomics and to investigate its clinical significance. GBMs in our study harbored mutually exclusive dominant expression of three RTKs; EGFR, PDGFRα and ERBB2. Therefore, we propose a subclassification of GBM with respect to the dominant expression of these proteins; EGFR (n=25), PDGFRα (n=11) and ERBB2 (n=7). PFS and OS tended to be longer in ERBB2 group in comparison with EGFR and PDGFRα group. Molecular subclassification of GBM based on the absolute quantitative proteomics reflects the clinical behavior and might have clinical significance.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Serine/Threonine kinase MLK4 determines Mesenchymal Identity in Glioma Stem Cells in an NFkB-dependent manner2016

    • Author(s)
      Kim SH, Ezhilarasan R, Chhipa R, Ladner K, Phillips E, Sparks A, Taylor D, Furuta T, Sabit H, Kurozumi K, Kuroiwa T, Akio A, Gallego-Perez1 D, Sulman EP, Cheng S, Lee J, Nakada M, Guttridge D, DasGupta B, Goidts V, Bhat KP, Walker J, Nakano I.
    • Journal Title

      Cancer Cell

      Volume: 29 Issue: 2 Pages: 201-213

    • DOI

      10.1016/j.ccell.2016.01.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells2015

    • Author(s)
      Tanaka S, Nakada M, Yamada D, Nakano I, Todo T, Ino Y, Hoshii T, Tadokoro Y, Ohta K, Ali MA, Hayashi Y, Hamada J, Hirao A.
    • Journal Title

      J Neurooncol.

      Volume: 121 Issue: 2 Pages: 239

    • DOI

      10.1007/s11060-014-1630-z

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1 and c-Jun N-terminal kinase-mediated pathway.2015

    • Author(s)
      Chikano Y, Domoto T, Furuta T, Sabit H, Kitano-Tamura A, Ilya V. Pyko, Takino T, Sai Y, Hayashi Y, Sato H, Miyamoto K, Nakada M, MinamotoT.
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: 14 Issue: 2 Pages: 564-574

    • DOI

      10.1158/1535-7163.mct-14-0479

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Biomarkers of glioblastoma identified by quantitative proteomics with SWATH mass spectrometry.2016

    • Author(s)
      Nakada M, Miyauchi E, Tachikawa M, Furuta T, Sabit H, Ohtsuki S, Terasaki T.
    • Organizer
      The 21st International Conference on Brain Tumor Research & Therapy
    • Place of Presentation
      Bankoku Shinryokan (Okinawa)
    • Year and Date
      2016-04-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 最先端プロテオミクスSWATH法による膠芽腫バイオマーカーの探索2015

    • Author(s)
      中田光俊,宮内英輔、立川正憲、古田拓也、淑瑠ヘムラサビット,大槻純男、寺崎哲也
    • Organizer
      第16回日本分子脳神経外科学会
    • Place of Presentation
      アクトシティ浜松コングレスセンター(浜松)
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Molecular subclassification of glioblastoma based on the absolute quantitative proteomics.2014

    • Author(s)
      Nakada M, Obuchi W, Ohtsuki S, Tanaka S, Furuta T, Kitabayashi T, Sabit H, Terasaki T, Hayashi Y.
    • Organizer
      Society for Neuro-Oncology 19th Annual Meeting 2014
    • Place of Presentation
      Loews Miami Beach Hotel (Miami, Florida, USA)
    • Year and Date
      2014-11-13 – 2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 絶対定量プロテオミクスによる新規膠芽腫サブタイプ分類の臨床的有用性の検討2014

    • Author(s)
      中田光俊,田中慎吾,小渕 航,大槻純男,古田拓也,宮下勝吉,寺崎哲也,林 裕
    • Organizer
      第15回日本分子脳神経外科学会
    • Place of Presentation
      山形(大手門パルズ)
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Research-status Report
  • [Remarks] 金沢大学脳神経外科

    • URL

      http://neurosurgery.w3.kanazawa-u.ac.jp/

    • Related Report
      2015 Annual Research Report 2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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