Identification of hemodynamic risk factors for the development of cerebral aneurysms using high-resolution computational blood flow analysis

• Project/Area Number: 26670647
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: SHIMOGONYA Yuji 東北大学, 学際科学フロンティア研究所, 助教 (30552575)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 脳動脈瘤 / 血流 / 血行力学 / 計算流体力学 / wall shear stress

Outline of Final Research Achievements

The purpose of this study was to identify the hemodynamic risk factors associated with the development of cerebral aneurysms. We constructed the patient-specific arterial models of middle cerebral artery (MCA) aneurysm based on CT images, and then approximately reconstructed the MCA models just before aneurysm development by virtually removing the aneurysm. Blood flow analyses for their models were performed with the computational fluid dynamics technique to compare hemodynamic metrics such as wall shear stress (WSS) between the aneurysm development site and normal site. A hemodynamic metric that quantifies WSS disturbances with multidirectional fluctuations was significantly higher at the aneurysm development site than the normal site. The results suggest that the multidirectionally disturbed WSS plays an important role in the development of cerebral aneurysms.

Research Products

• [Journal Article] Sustained expression of MCP-1 by low wall shear stress loading concomitant with turbulent flow on endothelial cells of intracranial aneurysm (2016)
  • Author(s): T. Aoki, K. Yamamoto, M. Fukuda, Y. Shimogonya, S. Fukuda, S. Narumiya
  • Journal Title: Acta Neuropathologica Communications Volume: 4 Issue: 1
  • DOI: 10.1186/s40478-016-0318-3
  • Peer Reviewed / Open Access
• [Journal Article] Computational and experimental studies into the hemodynamics of cerebral aneurysms (2016)
  • Author(s): Y. Shimogonya, S. Fukuda
  • Journal Title: Journal of Biomechanical Science and Engineering Volume: 11 Issue: 1 Pages: 15-00488-15-00488
  • DOI: 10.1299/jbse.15-00488
  • NAID: 130005157931
  • ISSN: 1880-9863
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Numerical methods for simulating blood flows at micro-, macro- and multi-scales (2016)
  • Author(s): Y. Imai, T. Omori, Shimogonya, Y., T. Ishikawa, T. Yamaguchi
  • Journal Title: Journal of Biomechanics Volume: in press Issue: 11 Pages: 2221-2228
  • DOI: 10.1016/j.jbiomech.2015.11.047
  • Peer Reviewed
• [Journal Article] The Role of Hemodynamic Factors on the Development, Enlargement, and Rupture of Cerebral Aneurysms : A Combination of Computational Fluid Dynamics Analysis and an Animal Model Study (2014)
  • Author(s): 福田俊一, 下權谷祐児
  • Journal Title: Japanese Journal of Neurosurgery Volume: 23 Issue: 8 Pages: 661-666
  • DOI: 10.7887/jcns.23.661
  • NAID: 130004682745
  • ISSN: 0917-950X, 2187-3100
  • Peer Reviewed / Open Access
• [Presentation] 中大脳動脈瘤と前交通動脈瘤の血行力学的比較 (2017)
  • Author(s): 下權谷 祐児, 福田 俊一
  • Organizer: 日本機械学会第29回バイオエンジニアリング講演会
  • Place of Presentation: ウインクあいち（愛知県名古屋市）
• [Presentation] Wall shear stress strength over the cerebral aneurysm Is drastically affected by aneurysm location while the magnitude of disturbed flow Is closely related to aneurysm size and surface area (2017)
  • Author(s): S. Fukuda, Y. Shimogonya
  • Organizer: International Stroke Conference 2017
  • Place of Presentation: Houston (USA)
  • Int'l Joint Research
• [Presentation] 計算流体力学(CFD)解析による未破裂脳動脈瘤の最大径および表面積による血行力学的因子の分布の相違の検討 (2017)
  • Author(s): 福田 俊一, 下權谷 祐児
  • Organizer: 第46回日本脳卒中の外科学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
• [Presentation] Surface area may be a more useful risk factor for cerebral aneurysm rupture than maximum diameter (2017)
  • Author(s): S. Fukuda, Y. Shimogonya
  • Organizer: Experimental Biology 2017
  • Place of Presentation: Chicago (USA)
  • Int'l Joint Research
• [Presentation] Hemodynamic localizations in anterior communicating artery aneurysms in comparison with middle cerebral artery aneurysms with computational fluid dynamics analysis (2016)
  • Author(s): S Fukuda, Y. Shimogonya, M. Fukuda, T. Tsukahara
  • Organizer: International Stroke Conference 2016
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2016-02-17
  • Int'l Joint Research
• [Presentation] 計算流体力学による破裂脳動脈瘤に関する検討：DISTURBED FLOWの観点から (2016)
  • Author(s): 下權谷 祐児, 福田 俊一
  • Organizer: 第39回日本バイオレオロジー学会年会
  • Place of Presentation: 東海大学校友会館（東京都千代田区）
• [Presentation] The importance of disturbed wall shear stress in the development of cerebral aneurysms (2016)
  • Author(s): Y. Shimogonya, S. Fukuda
  • Organizer: 22nd Congress of the European Society of Biomechanics
  • Place of Presentation: Lyon (France)
  • Int'l Joint Research
• [Presentation] 計算流体力学(CFD)解析による中大脳動脈瘤と前交通動脈瘤破裂率の相違に関する検討：CFD ABO Study中間報告 (2016)
  • Author(s): 福田 俊一, 下權谷 祐児
  • Organizer: 日本脳神経外科学会第75回学術総会
  • Place of Presentation: 福岡サンパレス（福岡県福岡市）
• [Presentation] Comparison of hemodynamics between middle cerebral artery and anterior communicating artery aneurysms (2016)
  • Author(s): Y. Shimogonya, S. Fukuda
  • Organizer: 16th International Conference on Biomedical Engineering
  • Place of Presentation: Singapore (Singapore)
  • Int'l Joint Research
• [Presentation] CFD解析は未破裂脳動脈瘤の診断・治療に貢献しうるか？多施設前向き臨床研究：CFD ABO Study中間解析結果 (2015)
  • Author(s): 福田 俊一, 下權谷 祐児
  • Organizer: 日本脳神経外科学会第74回学術総会
  • Place of Presentation: ロイトン札幌（北海道）
  • Year and Date: 2015-10-15
• [Presentation] Computational fluid dynamics for simulating the blood flow in arteries: its applications to hemodynamic analyses of the cerebral aneurysm formation (2015)
  • Author(s): Y. Shimogonya, S. Fukuda
  • Organizer: 40th Annual Meeting of Japanese Society for Microcirculation Satellite Symposium
  • Place of Presentation: Kyoto International Conference Center (Kyoto, Japan)
  • Year and Date: 2015-09-24
  • Int'l Joint Research / Invited
• [Presentation] Hemodynamic study on the initiation of cerebral aneurysms using left-right comparison method (2015)
  • Author(s): Y. Shimogonya, S. Fukuda, T. Ishikawa, T. Yamaguchi
  • Organizer: 8th Asian-Pacific Conference on Biomechanics
  • Place of Presentation: Hokkaido University (Sapporo, Japan)
  • Year and Date: 2015-09-17
  • Int'l Joint Research
• [Presentation] Hemodynamic analysis of the development of human cerebral aneurysms (2015)
  • Author(s): Y. Shimogonya, S. Fukuda, Y. Imoto
  • Organizer: The 18th International Conference on Finite Elements in Flow Problems
  • Place of Presentation: Taipei (Taiwan)
  • Year and Date: 2015-03-16
  • Invited
• [Presentation] Investigations using a combination of computational fluid dynamics technique and an animal model of experimentally induced cerebral aneurysms suggest important roles of wall shear stress on the cerebral aneurysm development (2015)
  • Author(s): S. Fukuda, Y. Shimogonya, M. Fukuda, K. Hasegawa
  • Organizer: International Stroke Conference 2015
  • Place of Presentation: Nashville (USA)
  • Year and Date: 2015-02-11
• [Presentation] 壁面せん断応力の時間的変化に注目した実形状脳動脈瘤の血行力学解析 (2015)
  • Author(s): 下權谷 祐児, 福田 俊一, 井本 恭秀, 熊丸 博滋
  • Organizer: 第27回バイオエンジニアリング講演会
  • Place of Presentation: 朱鷺メッセ（新潟県）
  • Year and Date: 2015-01-10
• [Presentation] Wall shear stress fluctuations in disturbed blood flow: calculation and classification (2014)
  • Author(s): Y. Shimogonya, K. Valen-Sendstad, D.A. Steinman
  • Organizer: 11th International Conference on Flow Dynamics
  • Place of Presentation: Senda International Center (Sendai, Japan)
  • Year and Date: 2014-10-08
  • Invited
• [Presentation] 流速実測値に基づく境界条件を用いた脳動脈瘤の血行力学解析 (2014)
  • Author(s): 井本 恭秀, 下權谷 祐児, 福田 俊一, 熊丸 博滋, 伊藤 和宏
  • Organizer: 第25回バイオフロンティア講演会
  • Place of Presentation: とりぎん文化会館（鳥取県）
  • Year and Date: 2014-10-03
• [Presentation] A novel framework for classifying wall shear stress phenotypes in arterial disturbed blood flow (2014)
  • Author(s): Y. Shimogonya, K. Valen-Sendstad, D.A. Steinman
  • Organizer: 7th World Congress of Biomechanics
  • Place of Presentation: Boston (USA)
  • Year and Date: 2014-07-07
• [Presentation] A framework for classifying and comparing wall shear stress fluctuations in disturbed blood flow (2014)
  • Author(s): Y. Shimogonya, K. Valen-Sendstad, D.A. Steinman
  • Organizer: International Symposium on Integrated Nanobiomechanics
  • Place of Presentation: Boston (USA)
  • Year and Date: 2014-07-06
• [Book] 基礎からよくわかる 実践的CFD（数値流体力学）入門 脳血管編 (2017)
  • Author(s): 高尾 洋之, 山本 誠, 鈴木 貴士, 増田 俊輔, 村山 雄一, 田中 美千裕, 石橋敏寛, 結城 一郎, 根本 繁, 渡邊 充祥, 滝川 知司, 松丸 祐司, 藤村 宗一郎, 木村 尚人, 面高 俊介, 杉山 慎一郎, 新妻 邦泰, 富永 悌二, 見崎 孝一, 下權谷 祐児 他
  • Total Pages: 277
  • Publisher: メディカ出版