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Identification of functional glyco-biomarkers during chondrogenesis of mouse iPS cells

Research Project

Project/Area Number 26670652
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionHokkaido University

Principal Investigator

Iwasaki Norimasa  北海道大学, 医学(系)研究科(研究院), 教授 (30322803)

Co-Investigator(Kenkyū-buntansha) ONODERA Tomohiro  北海大学, 大学病院, 講師 (70547174)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords幹細胞 / 軟骨細胞分化 / 糖鎖 / 軟骨代謝 / iPS細胞 / 分化マーカー
Outline of Final Research Achievements

Alterations in the structure of stem cell surface glycoforms were found during chondrogenesis. Based on the obtained results, several glycans are considered to play important roles in stem cell-derived chondrogenesis. The identified glycans have functional potential of chondrogenic biomarkers for the safety of cartilage regenerative medicine.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Chondrogenic Differentiation Of Mouse Induced Pluripotent Stem Cells (iPSCs) Using The Three Dimensional Culture With Ultra-purified Alginate Gel (UPAL Gel)2016

    • Author(s)
      Hontani K, Onodera T, Momma D, Matsuoka M, Baba R, Joutoku Z, Matsubara S, Homan K, Hishimura R, Kim WY, Iwasaki N
    • Journal Title

      ORS Transaction

      Volume: 41 Pages: 1376-1376

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Chondrogenic Differentiation Of Mouse Induced Pluripotent Stem Cells (iPSCs) Using The Three Dimensional Culture With Ultra-purified Alginate Gel (UPAL Gel)2016

    • Author(s)
      Hontani K, Onodera T, Momma D, Matsuoka M, Baba R, Joutoku Z, Matsubara S, Homan K, Hishimura R, Kim WY, Iwasaki N
    • Organizer
      ORS 2016 Annual Meeting
    • Place of Presentation
      Orland,FL,USA
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ultra-purified alginate gel(UPAL gel)と多段階分化誘導法を併用したマウスiPS細胞の生体内における軟骨分化誘導2016

    • Author(s)
      本谷和俊、小野寺智洋、寺島理代、門間太輔、松岡正剛、馬場力哉、上徳善太、松原新史、宝満健太郎、菱村亮介、岩崎倫政
    • Organizer
      第29回 日本軟骨代謝学会
    • Place of Presentation
      広島
    • Year and Date
      2016-02-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 軟骨再生医学の臨床応用 -基礎から臨床へ向けてー2015

    • Author(s)
      岩崎倫政
    • Organizer
      Sapporo Orthopaedic Seminar 2015
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 高純度アルギン酸ゲルと多段階分化誘導法を併用したマウスiPS細胞軟骨分化誘導法の確立2015

    • Author(s)
      本谷和俊、小野寺智洋、寺島理代、門間太輔、松岡正剛、馬場力哉、上徳善太、松原新史、宝満健太郎、岩崎倫政
    • Organizer
      第30回 日本整形外科学会基礎学術集会
    • Place of Presentation
      富山
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] An acellular cartilage tissue repair technique using an ultrapurified alginate gel for the treatment of rabbit osteochondral defects2015

    • Author(s)
      Iwasaki N, Baba R, Momma D, Matsuoka M, Hontani K, Onodera T
    • Organizer
      Biomaterials International 2015
    • Place of Presentation
      Kenting,Taiwan
    • Year and Date
      2015-06-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chondrogenic differentiation of mouse Induced pluripotent stem cells (iPSCs) using ultra-purified alginate gel (UPAL gel)2015

    • Author(s)
      Hontani K, Onodera T, Momma D, Matsuoka M, Baba R, Iwasaki N
    • Organizer
      International Cartilage Repair Society 2015
    • Place of Presentation
      Chicago,IL,USA
    • Year and Date
      2015-05-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ultra-purified alginate gel (UPAL gel) を用いたマウス人工多能性幹細胞(iPS細胞)からの軟骨細胞分化誘導2015

    • Author(s)
      本谷和俊、小野寺智洋、岩崎倫政、他
    • Organizer
      第28回日本軟骨代謝学会
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2015-03-06 – 2015-03-07
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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